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655 records – page 1 of 33.

International classification of functioning, disability and health: ICF

https://cwslc.andornot.com/en/permalink/catalog108122
World Health Organization. Geneva: World Health Organization
Website
www.who.int/classifications/icf/en/
Material Type
Online
This publication describes how people live with their health condition. It is a classification of health-related domains that describe body functions and structures, activities and participation. The domains are classified from body, individual and societal perspectives.; Since an individual's func…
Website
www.who.int/classifications/icf/en/
Corporate Author
World Health Organization.
Place of Publication
Geneva
Publisher
World Health Organization
Subject
Medical Dictionaries. Medical Thesauri. Medical Terminology
Anatomy
Physiology
Abstract
This publication describes how people live with their health condition. It is a classification of health-related domains that describe body functions and structures, activities and participation. The domains are classified from body, individual and societal perspectives.
Since an individual's functioning and disability occurs in a context, "ICF" also includes a list of environmental factors. The "ICF" should be useful to understand and measure health outcomes.
It can be used in clinical settings, health services or surveys at the individual or population level.
Notes
"The text represents a revision of the International Classification of Impairments, Disabilities, and Handicaps (ICIDH), which was originally published by the World Health Organization for trial purposes in 1980"--P. 3.
ISBN
9241545429
Language
Arabic
Chinese
English
French
Russian
Spanish
Material Type
Online
Websites
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The COMFORT behaviour scale

https://cwslc.andornot.com/en/permalink/catalog109592
Van Dijk, Monique. Rotterdam, [Netherlands]: , 2004.
Material Type
CD
Audio
Call Number
FM 800 VAN 2004
This instructional CD-rom demonstrates how 'the COMFORT behaviour scale' for postoperative pain assessment in neonates and infants works in practice.
Corporate Author
Van Dijk, Monique
Place of Publication
Rotterdam, [Netherlands]
Publication Date
2004
Physical Description
1 CD-rom
Subject
Pain
Infants
Caregivers
Abstract
This instructional CD-rom demonstrates how 'the COMFORT behaviour scale' for postoperative pain assessment in neonates and infants works in practice.
Notes
Advised System:
Windows 98SE or higher
Pentium III 900 mHz or higher
8 speed CD-rom or higher
Quicktime 4 or higher (installer on CD-rom)
Language
English
Material Type
CD
Audio
Call Number
FM 800 VAN 2004
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A people lens: 101 ways to move your organization forward

https://cwslc.andornot.com/en/permalink/catalog111058
Volunteer Vancouver. Vancouver, B.C.: Volunteer Vancouver , 2009.
Material Type
Book
Call Number
REF BD 600 PEO 2009
This book is for voluntary leaders of non-profit organizations and provides volunteer stories to illustrate and inspire leadership in any organization.
Corporate Author
Volunteer Vancouver
Place of Publication
Vancouver, B.C.
Publisher
Volunteer Vancouver
Publication Date
2009
Physical Description
Paperback: 71 p.
Subject
Job Satisfaction
Work Behaviour
Volunteers
Abstract
This book is for voluntary leaders of non-profit organizations and provides volunteer stories to illustrate and inspire leadership in any organization.
Language
English
Material Type
Book
Call Number
REF BD 600 PEO 2009
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Synthesizing qualitative research: Choosing the right approach

https://cwslc.andornot.com/en/permalink/catalog112047
Hannes, Karin (ed.), Lockwood, Craig (ed.). West Sussex, UK: Wiley-Blackwell , 2012.
Material Type
Book
Call Number
IA 605 HAN 2012
This book acts as a resource for readers who would otherwise have to piece together the methodology about qualitative research from a range of journal articles. It brings balance to the options available to researchers, including approaches that have not had a substantial uptake among researchers. …
Author
Hannes, Karin (ed.)
Lockwood, Craig (ed.)
Place of Publication
West Sussex, UK
Publisher
Wiley-Blackwell
Publication Date
2012
Physical Description
Softcover; 179 pp.
Subject
Research Design
Human Experimental Research
Abstract
This book acts as a resource for readers who would otherwise have to piece together the methodology about qualitative research from a range of journal articles. It brings balance to the options available to researchers, including approaches that have not had a substantial uptake among researchers. It provides arguments for when and why researchers or other parties of interest should opt for a certain approach to synthesis, which challenges they might face in adopting it and what the potential strengths and weaknesses are compared with other approaches.
ISBN
978-0-470-65638-9
Language
English
Material Type
Book
Call Number
IA 605 HAN 2012
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Learning healthcare system: Workshop summary (IOM Roundtable on Evidence-Based Medicine)

https://cwslc.andornot.com/en/permalink/catalog113231
Olsen, LeighAnne;, Aisner, Dara;, McGinnis, J. Michael (Eds). Washington, DC: National Academies Press , 2007.
Website
http://www.nap.edu/catalog.php?record_id=11903
Material Type
Online
This book considers how health care is structured to develop and to apply evidence--from health profession training and infrastructure development to advances in research methodology, patient engagement, payment schemes, and measurement--and highlights opportunities for the creation of a sustainabl…
Website
http://www.nap.edu/catalog.php?record_id=11903
Website Notes
Read online or download as PDF.
Author
Olsen, LeighAnne;
Aisner, Dara;
McGinnis, J. Michael (Eds).
Place of Publication
Washington, DC
Publisher
National Academies Press
Publication Date
2007
Physical Description
374 pages, 2 MB PDF file.
Subject
Health Care Delivery Systems
Evidence-Based Medicine
Abstract
This book considers how health care is structured to develop and to apply evidence--from health profession training and infrastructure development to advances in research methodology, patient engagement, payment schemes, and measurement--and highlights opportunities for the creation of a sustainable learning health care system that gets the right care to people when they need it and then captures the results for improvement. This book will be of primary interest to hospital and insurance industry administrators, health care providers, those who train and educate health workers, researchers, and policymakers.
ISBN
978-0-309-10300-8
Language
English
Material Type
Online
Websites
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Advanced cardiovascular life support (ACLS): Instructor manual

https://cwslc.andornot.com/en/permalink/catalog113245
Sinz, Elizabeth (ed.), Navarro, Kenneth (ed.). USA: Heart & Stroke Foundation of Canada , 2010.
Material Type
Book
The ACLS Instructor Manual includes essential information and Lesson Maps that HSFC ACLS Instructors need to teach the ACLS Course (initial/full course, update/renewal course). Updated to reflect new science in the 2010 Guidelines for CPR & ECC. Teaches skills using the Practice-While-Watching tech…
Author
Sinz, Elizabeth (ed.)
Navarro, Kenneth (ed.)
Place of Publication
USA
Publisher
Heart & Stroke Foundation of Canada
Publication Date
2010
Physical Description
Loose pages in shrink wrap, 3 hole punched
Subject
First Aid
Certification
CPR
Abstract
The ACLS Instructor Manual includes essential information and Lesson Maps that HSFC ACLS Instructors need to teach the ACLS Course (initial/full course, update/renewal course). Updated to reflect new science in the 2010 Guidelines for CPR & ECC. Teaches skills using the Practice-While-Watching technique, allowing the instructor to observe the student, provide feedback, and guide the students acquisition of skills.
ISBN
9781926969183
Language
English
Material Type
Book
Images
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2015 handbook of emergency cardiovascular care for healthcare providers

https://cwslc.andornot.com/en/permalink/catalog113897
American Heart Association, Heart & Stroke Foundation. , 2015.
Material Type
Book
This handbook contains the 2015 Canadian guidelines for resuscitation and first aid. It is intended to be used by healthcare professionals in emergency, intensive care, or critical care departments; emergency medical care providers; first responders; and AHA and other healthcare instructors. The ha…
Author
American Heart Association
Heart & Stroke Foundation
Publication Date
2015
Physical Description
Pocket-sized, spiral bound, 6.25" x 4" book; 216 pages.
Abstract
This handbook contains the 2015 Canadian guidelines for resuscitation and first aid. It is intended to be used by healthcare professionals in emergency, intensive care, or critical care departments; emergency medical care providers; first responders; and AHA and other healthcare instructors. The handbook is organized into sections for basic, advanced adult, and pediatric life support and newborn resuscitation. It provides algorithms for BCLS, ACLS and PALS, protocols, sequences, drug dosages, and more.
ISBN
9781926969367
Language
English
Material Type
Book
Images
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Aggressive behavior

https://cwslc.andornot.com/en/permalink/catalog113908
Website
PHSA Users:
http://search.ebscohost.com/login.aspx?direct=true&db=byh&jid=AGG&site=ehost-live
UBC Users:
http://resolve.library.ubc.ca/cgi-bin/catsearch?bid=1193239
Place of Publication
Hoboken, N.J.
Publisher
John Wiley & Sons, Inc.
Notes
Official Journal of the International Society for Research on Aggression.
ISSN
0096-140X
Language
English
Material Type
Serial
Frequency
Bimonthly
Holdings
CFRI/Study & Learning Commons - Print: v.29:2-v.32:1 (2003-2006)
Online: 1974-
Websites
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Profiling the vaginal microbiome in HIV-positive women

https://cwslc.andornot.com/en/permalink/catalog113942
Mahal, Daljeet Singh. Vancouver, BC: University of British Columbia , 2013.
Website
http://hdl.handle.net/2429/44267
Material Type
Thesis
Call Number
Thesis Shelf
Disruptions or imbalances of the vaginal microbiome can lead to negative reproductive health consequences for women, including an increased risk of sexually transmitted infections, pelvic inflammatory disease, and preterm birth. HIV-positive women may be particularly vulnerable to microbiome disrup…
Website
http://hdl.handle.net/2429/44267
Author
Mahal, Daljeet Singh
Place of Publication
Vancouver, BC
Publisher
University of British Columbia
Publication Date
2013
Subject
Faculty of Medicine
Theses
Abstract
Disruptions or imbalances of the vaginal microbiome can lead to negative reproductive health consequences for women, including an increased risk of sexually transmitted infections, pelvic inflammatory disease, and preterm birth. HIV-positive women may be particularly vulnerable to microbiome disruptions due to the immune dysfunction intrinsic to this disease. The objective of this study was to explore the vaginal microbiome in HIV-positive reproductive-aged women utilizing cpn60 metagenomic profiling and to correlate vaginal bacterial profiles with demographic/clinical variables.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Cardiovascular, metabolic, endocrine and behavioral aspects of development in postnatal lambs in relation to age, sex, lamb number and acute fluoxetine administration

https://cwslc.andornot.com/en/permalink/catalog113943
Nguyen, Tuan-Anh Thi. Vancouver, BC: University of British Columbia , 2013.
Website
http://hdl.handle.net/2429/44653
Material Type
Thesis
Call Number
Thesis Shelf
Human newborns exposed in utero to maternally administered SSRIs such as fluoxetine (FX) have an increased risk of adverse pregnancy outcomes including poor neonatal adaptation. This comprises respiratory difficulty, jitteriness, cyanosis when feeding and persists for several days after birth. Seve…
Website
http://hdl.handle.net/2429/44653
Author
Nguyen, Tuan-Anh Thi
Place of Publication
Vancouver, BC
Publisher
University of British Columbia
Publication Date
2013
Subject
Faculty of Medicine
Theses
Abstract
Human newborns exposed in utero to maternally administered SSRIs such as fluoxetine (FX) have an increased risk of adverse pregnancy outcomes including poor neonatal adaptation. This comprises respiratory difficulty, jitteriness, cyanosis when feeding and persists for several days after birth. Several potential mechanisms underlying these symptoms have been proposed: 1) acute toxicity to the drugs (i.e. serotonin syndrome), 2) withdrawal syndrome due to the sudden discontinuation of maternal-fetal placental drug transfer at birth or 3) an SSRIs-elicited alteration in fetal brain development. However, the actual mechanism has not been elucidated.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Role of receptor tyrosine kinase regulator Sprouty in ovarian cancer cells

https://cwslc.andornot.com/en/permalink/catalog113944
So, Wai Kin. Vancouver, BC: University of British Columbia , 2012.
Website
http://hdl.handle.net/2429/42242
Material Type
Thesis
Call Number
Thesis Shelf
Aberrant epidermal growth factor receptor (EGFR) activity contributes to the development of epithelial ovarian cancer (EOC), a common and lethal female malignancy. Elucidating the regulation of EGFR function will improve treatments for EOC and the survival of patients. This study aims to elucidate …
Website
http://hdl.handle.net/2429/42242
Author
So, Wai Kin
Place of Publication
Vancouver, BC
Publisher
University of British Columbia
Publication Date
2012
Subject
Faculty of Medicine
Theses
Abstract
Aberrant epidermal growth factor receptor (EGFR) activity contributes to the development of epithelial ovarian cancer (EOC), a common and lethal female malignancy. Elucidating the regulation of EGFR function will improve treatments for EOC and the survival of patients. This study aims to elucidate the role of Sprouty (SPRY) proteins, which are EGFR regulators, in EOC.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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X-chromosome inactivation and FMR1 CGG repeat and AGG interspersion number in female newborns conceived by assisted reproductive technologies (ARTs)

https://cwslc.andornot.com/en/permalink/catalog113945
Wu, Elizabeth Xianshi. Vancouver, BC: University of British Columbia , 2012.
Website
http://hdl.handle.net/2429/42609
Material Type
Thesis
Call Number
Thesis Shelf
Pregnancies derived from in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with increased rates of chromosome abnormalities, congenital malformations, low birth weight, pre-term births, multiple gestations, and imprinting disorders. Assisted reproductive techno…
Website
http://hdl.handle.net/2429/42609
Author
Wu, Elizabeth Xianshi
Place of Publication
Vancouver, BC
Publisher
University of British Columbia
Publication Date
2012
Subject
Faculty of Medicine
Theses
Abstract
Pregnancies derived from in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with increased rates of chromosome abnormalities, congenital malformations, low birth weight, pre-term births, multiple gestations, and imprinting disorders. Assisted reproductive technologies (ARTs) enable sub-fertile individuals to circumvent the natural selective pressures involved in human reproduction. The risks of ARTs may be due to the underlying causes of subfertility in these individuals or to the artificial processes used to achieve pregnancy. X-chromosome inactivation (XCI) may be at risk to perturbations in ARTs as it is thought to occur during the blastocyst stage when in vitro culturing would be taking place. We examined the XCI status in females conceived by ICSI (n=70), IVF (n=68), and naturally (NC, n=42).
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Noninvasive assessment of embryo quality in human in vitro fertilization : metabolomic profiling of embryo culture media with Raman spectroscopy

https://cwslc.andornot.com/en/permalink/catalog113946
Asghari Roodsari, Alaleh. Vancouver, BC: University of British Columbia , 2012.
Website
http://hdl.handle.net/2429/43273
Material Type
Thesis
Call Number
Thesis Shelf
Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. …
Website
http://hdl.handle.net/2429/43273
Author
Asghari Roodsari, Alaleh
Place of Publication
Vancouver, BC
Publisher
University of British Columbia
Publication Date
2012
Subject
Faculty of Medicine
Theses
Abstract
Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. We therefore undertook the following study to further assess the usefulness of metabolomic profiling ?spent? embryo culture medium using Raman spectroscopy. Methods: Patients undergoing IVF+/-ICSI treatment from the UBC Centre for Reproductive Health were recruited for study.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Investigation of methylation and gene expression in placenta of pregnancies conceived by assisted reproductive technology (ART)

https://cwslc.andornot.com/en/permalink/catalog113947
Sakian, Sina. Vancouver, BC: University of British Columbia , 2011.
Website
http://hdl.handle.net/2429/31191
Material Type
Thesis
Call Number
Thesis Shelf
With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures wi…
Website
http://hdl.handle.net/2429/31191
Author
Sakian, Sina
Place of Publication
Vancouver, BC
Publisher
University of British Columbia
Publication Date
2011
Subject
Faculty of Medicine
Theses
Abstract
With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures with increased incidence of low birth weight (LBW), chromosomal abnormalities, birth defects and imprinting disorders. No study has proposed a single defined cause for any of these defects in ART infants, however it is believed that they may be due to both the invasiveness of ART and to genetic defects that are at the root of the infertility in the parents. In this study, changes in the methylation of the H19 and IGF2 imprinting control region 1 (ICR1) were investigated for both ART (n=92) and naturally conceived controls (n=19) using pyrosequencing.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Regulation of androgen action by sex hormone-binding globulin

https://cwslc.andornot.com/en/permalink/catalog113948
Hong, Eui-ju. Vancouver, BC: University of British Columbia , 2011.
Website
http://hdl.handle.net/2429/35861
Material Type
Thesis
Call Number
Thesis Shelf
Sex hormone-binding globulin (SHBG) binds androgens and estrogens with high affinity, and regulates the distribution of these sex steroids in the blood and other biological fluids. Liver is the primary site of SHBG production, but the human SHBG transcription unit responsible for this is also expre…
Website
http://hdl.handle.net/2429/35861
Author
Hong, Eui-ju
Place of Publication
Vancouver, BC
Publisher
University of British Columbia
Publication Date
2011
Subject
Faculty of Medicine
Theses
Abstract
Sex hormone-binding globulin (SHBG) binds androgens and estrogens with high affinity, and regulates the distribution of these sex steroids in the blood and other biological fluids. Liver is the primary site of SHBG production, but the human SHBG transcription unit responsible for this is also expressed in proximal convoluted tubule (PCT) epithelial cells in a transgenic mouse model. Unlike hepatocytes which actively secrete SHBG and retain little immunoreactive SHBG within their cytoplasm, an incompletely glycosylated SHBG isoform has been found to accumulate inside PCT cells. These cells are androgen target cells, and the presence of SHBG within them accentuates androgen-dependent regulation of gene expression mediated by the androgen receptor (AR).
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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The characterization of ADAMTS-12 in the regulation of human trophoblast invasion in vitro

https://cwslc.andornot.com/en/permalink/catalog113949
Zou, Junxuan. Vancouver, BC: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/29783
Material Type
Thesis
Call Number
Thesis Shelf
The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We ex…
Website
http://hdl.handle.net/2429/29783
Author
Zou, Junxuan
Place of Publication
Vancouver, BC
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We examined the presence of ADAMTS in first trimester human placenta and only ADAMTS-12 was present in cultures of invasive extravillous cytotrophoblast (EVT) at significantly higher levels than in poorly invasive JEG-3 chorocarcinoma cells. Immunohistochemistry staining of chorionic villi derived from first trimester human placenta demonstrated that ADAMTS-12 was intensively immunolocalized in the cytotrophoblast layer but weakly immunolocalized in the poorly-invasive syncytial trophoblast layer.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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DNA methylation at imprinted and non-imprinted genes in the sperm of men affected by severe male factor infertility

https://cwslc.andornot.com/en/permalink/catalog113950
Minor, Agata. Vancouver, BC: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/29282
Material Type
Thesis
Call Number
Thesis Shelf
Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA met…
Website
http://hdl.handle.net/2429/29282
Author
Minor, Agata
Place of Publication
Vancouver, BC
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA methylation would be present in the ejaculate and testicular sperm of men affected by severe male factor infertility compared to that in fertile control men. Furthermore, we hypothesized abnormal DNA methylation would also affect non-imprinted genes in the sperm of men affected by severe oligozoospermia.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Effects and mechanisms of growth differentiation factor 9 on activin A-regulated inhibin B and progesterone production in human granulosa cells

https://cwslc.andornot.com/en/permalink/catalog113951
Shi, Fengtao. Vancouver, BC: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/28961
Material Type
Thesis
Call Number
Thesis Shelf
Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regul…
Website
http://hdl.handle.net/2429/28961
Author
Shi, Fengtao
Place of Publication
Vancouver, BC
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regulator of ovarian function, but its overall effects, particularly relating to activin A actions, are unknown. We examined the potential crosstalk between activin A and GDF9 in primary cultures of human granulosa-lutein (hGL) cells. Pretreatment of hGL cells with GDF9 for 24 h resulted in an increased expression of activin receptors and Smad2/3, and decreased inhibitory Smad7 activity. These effects were attenuated by BMP type II receptor ectodomain (BMPR2 ECD), a GDF9 antagonist.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Ligand-independent activation of steroid hormone receptors by gonadotropin-releasing hormone

https://cwslc.andornot.com/en/permalink/catalog113952
Chen, Junling. Vancouver, BC: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/34980
Material Type
Thesis
Call Number
Thesis Shelf
Nuclear receptors including estrogen receptors (ERs) and progesterone receptors (PRs) are activated by their ligands as well as by signaling pathways in response to peptide hormones and growth factors. In gonadotrophs, gonadotropin releasing hormones (GnRHs) act via the GnRH receptor (GnRHR). Both …
Website
http://hdl.handle.net/2429/34980
Author
Chen, Junling
Place of Publication
Vancouver, BC
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
Nuclear receptors including estrogen receptors (ERs) and progesterone receptors (PRs) are activated by their ligands as well as by signaling pathways in response to peptide hormones and growth factors. In gonadotrophs, gonadotropin releasing hormones (GnRHs) act via the GnRH receptor (GnRHR). Both GnRH-I and GnRH-II activate an estrogen response element (ERE)-driven luciferase reporter gene in LβT2 mouse pituitary cells, and GnRH-I is more potent in this regard.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Human gonadotropin-releasing hormone-II regulation in ovarian cancer : mechanisms and potential functional role

https://cwslc.andornot.com/en/permalink/catalog113953
Poon, Song Ling. Vancouver, BC: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/30021
Material Type
Thesis
Call Number
Thesis Shelf
It is increasingly apparent that GnRH-II acts as an autocrine/paracrine regulator in non-pituitary tissues, in addition to its role in the regulation of gonadotropin synthesis, and is an important player in cancer cell biology. High levels of GnRH-II and GnRHR in malignant ovarian tumors as compare…
Website
http://hdl.handle.net/2429/30021
Author
Poon, Song Ling
Place of Publication
Vancouver, BC
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
It is increasingly apparent that GnRH-II acts as an autocrine/paracrine regulator in non-pituitary tissues, in addition to its role in the regulation of gonadotropin synthesis, and is an important player in cancer cell biology. High levels of GnRH-II and GnRHR in malignant ovarian tumors as compared with benign ovarian tissues underlies the importance of understanding GnRH-II function in ovarian cancer. In an attempt to define the regulation of GnRH-II in these tissues, we found that a cyclic-AMP responsive element (CRE) is critical for GnRH-II promoter transcription.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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655 records – page 1 of 33.