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2 records – page 1 of 1.

Physical and functional interaction of p53 and p110a and implications in ovarian carcinogenesis

https://cwslc.andornot.com/en/permalink/catalog113967
Astanehe, Arezoo. [Vancouver, BC?]: University of British Columbia , 2005.
Website
http://hdl.handle.net/2429/16421
Material Type
Thesis
Call Number
Thesis Shelf
n approximately 40% of ovarian cancers, PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) is amplified. This amplification correlates with increased PIK3CA transcription, p110α protein expression, and PI3K activity. Moreover, PIK3CA is implicated as…
More Information is Available
  1 website  
Website
http://hdl.handle.net/2429/16421
Author
Astanehe, Arezoo
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2005
Subject
Faculty of Medicine
Theses
Abstract
n approximately 40% of ovarian cancers, PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) is amplified. This amplification correlates with increased PIK3CA transcription, p110α protein expression, and PI3K activity. Moreover, PIK3CA is implicated as an oncogene in ovarian cancers. Another common mutation in ovarian cancer leads to loss of p53 function. Alterations to p53 are known to be involved in tumour development and progression.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
http://hdl.handle.net/2429/16421
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The PIERS (Pre-eclampsia Integrated Estimate of RiSk) model : development of a valid outcome prediction model for pre-eclampsia.

https://cwslc.andornot.com/en/permalink/catalog113957
Menzies, Jennifer Marie. [Vancouver, BC?]: University of British Columbia , 2009.
Website
http://hdl.handle.net/2429/6844
Material Type
Thesis
Call Number
Thesis Shelf
Availability
1 copy, 1 available
This research responded to the need to define evidence-based criteria of maternal risk by developing a model - the Pre-eclampsia Integrated Estimate of RiSk (or PIERS) model ? that predicts a combined adverse maternal outcome (mortality and/or significant morbidities) within 48 hour of, and up to s…
More Information is Available
  1 website  
Website
http://hdl.handle.net/2429/6844
Author
Menzies, Jennifer Marie
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2009
Subject
Faculty of Medicine
Theses
Abstract
This research responded to the need to define evidence-based criteria of maternal risk by developing a model - the Pre-eclampsia Integrated Estimate of RiSk (or PIERS) model ? that predicts a combined adverse maternal outcome (mortality and/or significant morbidities) within 48 hour of, and up to seven days after, admission with pre-eclampsia (study eligibility)
Language
English
Material Type
Thesis
Call Number
Thesis Shelf

Copies

Copy 1 BC Children's and Women's Study and Learning Commons Thesis Shelf Available
Websites
http://hdl.handle.net/2429/6844
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