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2 records – page 1 of 1.

Physical and functional interaction of p53 and p110a and implications in ovarian carcinogenesis

https://cwslc.andornot.com/en/permalink/catalog113967
Astanehe, Arezoo. [Vancouver, BC?]: University of British Columbia , 2005.
Website
http://hdl.handle.net/2429/16421
Material Type
Thesis
Call Number
Thesis Shelf
n approximately 40% of ovarian cancers, PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) is amplified. This amplification correlates with increased PIK3CA transcription, p110α protein expression, and PI3K activity. Moreover, PIK3CA is implicated as…
More Information is Available
  1 website  
Website
http://hdl.handle.net/2429/16421
Author
Astanehe, Arezoo
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2005
Subject
Faculty of Medicine
Theses
Abstract
n approximately 40% of ovarian cancers, PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) is amplified. This amplification correlates with increased PIK3CA transcription, p110α protein expression, and PI3K activity. Moreover, PIK3CA is implicated as an oncogene in ovarian cancers. Another common mutation in ovarian cancer leads to loss of p53 function. Alterations to p53 are known to be involved in tumour development and progression.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
http://hdl.handle.net/2429/16421
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Fish analysis of chromosomal aneuploidies in spermatozoa from severely infertile men undergoing intracytoplasmic sperm injection (ICSI)

https://cwslc.andornot.com/en/permalink/catalog113969
Gao, Haijun. [Vancouver, BC?]: University of British Columbia , 2004.
Website
http://hdl.handle.net/2429/16195
Material Type
Thesis
Call Number
Thesis Shelf
The association between subsets of male infertility, oligoasthenoteratozoospermia (OAT), obstructive azoospermic (OA), non-obstructive azoospermia (NOA), and increased risk of having chromosomal abnormalities in the sperm has not been investigated. Chromosomal aneuploidy in sperm will be systematic…
More Information is Available
  1 website  
Website
http://hdl.handle.net/2429/16195
Author
Gao, Haijun
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2004
Subject
Faculty of Medicine
Theses
Abstract
The association between subsets of male infertility, oligoasthenoteratozoospermia (OAT), obstructive azoospermic (OA), non-obstructive azoospermia (NOA), and increased risk of having chromosomal abnormalities in the sperm has not been investigated. Chromosomal aneuploidy in sperm will be systematically investigated by standard methods with large sample sizes required to present significance.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
http://hdl.handle.net/2429/16195
Show Less