Website

http://hdl.handle.net/2429/44653

Author

Nguyen, Tuan-Anh Thi

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2013

Subject

Faculty of Medicine

Theses

Abstract

Human newborns exposed in utero to maternally administered SSRIs such as fluoxetine (FX) have an increased risk of adverse pregnancy outcomes including poor neonatal adaptation. This comprises respiratory difficulty, jitteriness, cyanosis when feeding and persists for several days after birth. Several potential mechanisms underlying these symptoms have been proposed: 1) acute toxicity to the drugs (i.e. serotonin syndrome), 2) withdrawal syndrome due to the sudden discontinuation of maternal-fetal placental drug transfer at birth or 3) an SSRIs-elicited alteration in fetal brain development. However, the actual mechanism has not been elucidated.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/29326

Author

Yun, Young Won

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1989

Subject

Faculty of Medicine

Theses

Abstract

This study examined primary defects and related mechanisms leading to impaired fertility following superovulation with exogenous gonadotropin. Experiments were designed to address the ovulatory response, oocyte quality (gross morphology and nuclear maturation) and embryo development with reference to ovarian steroid and circulating LH levels in immature rats treated with 4, 20 or 40 IU pregnant mare's serum gonadotropin (PMSG).

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/4814

Author

Katagiri, Seiji

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1996

Subject

Faculty of Medicine

Theses

Abstract

Superovulation causes detrimental effects, including embryonic loss and implantation failure. This study determined potential roles for insulin-like growth factor (IGF-I) in uterine environment regulation and preimplantation development, in conjunction with the detrimental effects of superovulation in the rat. IGF-I may be beneficial to preimplantation embryonic development. IGF-I stimulated embryonic development and metabolism in vitro and increased the rate of implantation and fetal development when the blastocysts were transferred into a receptive uterus.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/30962

Author

Britton, Ann Patricia

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1991

Subject

Faculty of Medicine

Theses

Abstract

A delicate balance of steroid and gonadotrophic hormones is essential for intrafollicular oocyte maturation and successful fertilization and embryonic development. Previous studies have demonstrated that a superovulatory dose of pregnant mare serum gonadotrophin (PMSG) has excessive gonadotrophic activity and alters intrafol1icular steroid hormone levels. In a series of four experiments, the morphology of oocytes and embryos retrieved from immature rats, treated with either a low or high dose of PMSG, and mature, cycling rats was compared to determine whether a superovulatory dose of PMSG has an adverse effect on oocyte maturation and subsequent fertilization and embryonic development in immature rats. Morphological criteria for the assessment of intraoviductal oocyte aging were established in the first experiment.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/6844

Author

Menzies, Jennifer Marie

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2009

Subject

Faculty of Medicine

Theses

Abstract

This research responded to the need to define evidence-based criteria of maternal risk by developing a model - the Pre-eclampsia Integrated Estimate of RiSk (or PIERS) model ? that predicts a combined adverse maternal outcome (mortality and/or significant morbidities) within 48 hour of, and up to seven days after, admission with pre-eclampsia (study eligibility)

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Copies

Author

Ammerican Academy of Orthopaedic Surgeons (AAOS)

Place of Publication

Warsaw, IN

Publisher

Zimmer Inc.

Publication Date

2005

Physical Description

1 CD-ROM

Subject

Cross-Cultural Health Care

Minority Health

Patient-Health Care Practitioner Relations. Doctor-Patient Relations.

Patient Relations

Abstract

The Cultural Competency Challenge is a self-assessment and learning tool, showcasing 18 diverse patient cases, designed to help surgeons become more aware of cultural differences among their patients, including communication and clinical considerations.

Notes

AAOS Product: #02735

Language

English

Material Type

CD

Audio

Call Number

REF GN 300 CUL 2005

Copies