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2 records – page 1 of 1.

Noninvasive assessment of embryo quality in human in vitro fertilization : metabolomic profiling of embryo culture media with Raman spectroscopy

https://cwslc.andornot.com/en/permalink/catalog113946
Asghari Roodsari, Alaleh. [Vancouver, BC?]: University of British Columbia , 2012.
Website
http://hdl.handle.net/2429/43273
Material Type
Thesis
Call Number
Thesis Shelf
Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. …
Website
http://hdl.handle.net/2429/43273
Author
Asghari Roodsari, Alaleh
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2012
Subject
Faculty of Medicine
Theses
Abstract
Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. We therefore undertook the following study to further assess the usefulness of metabolomic profiling ?spent? embryo culture medium using Raman spectroscopy. Methods: Patients undergoing IVF+/-ICSI treatment from the UBC Centre for Reproductive Health were recruited for study.
Language
English
Material Type
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Physical and functional interaction of p53 and p110a and implications in ovarian carcinogenesis

https://cwslc.andornot.com/en/permalink/catalog113967
Astanehe, Arezoo. [Vancouver, BC?]: University of British Columbia , 2005.
Website
http://hdl.handle.net/2429/16421
Material Type
Thesis
Call Number
Thesis Shelf
n approximately 40% of ovarian cancers, PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) is amplified. This amplification correlates with increased PIK3CA transcription, p110α protein expression, and PI3K activity. Moreover, PIK3CA is implicated as…
Website
http://hdl.handle.net/2429/16421
Author
Astanehe, Arezoo
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2005
Subject
Faculty of Medicine
Theses
Abstract
n approximately 40% of ovarian cancers, PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) is amplified. This amplification correlates with increased PIK3CA transcription, p110α protein expression, and PI3K activity. Moreover, PIK3CA is implicated as an oncogene in ovarian cancers. Another common mutation in ovarian cancer leads to loss of p53 function. Alterations to p53 are known to be involved in tumour development and progression.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
Show Less