Website

http://hdl.handle.net/2429/33832

Author

Chan Wong, Edgar Antonio

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2011

Subject

Faculty of Medicine

Theses

Abstract

In-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are two of the most common forms of assisted reproductive technologies (ARTs) used to treat human infertility. Presently, over two million children have been conceived by ART. The majority of these children are born healthy. However, IVF and ICSI have been associated with increased risks of adverse perinatal health outcomes. The higher risk of low birth weight, intrauterine growth restriction, and small for gestational age are of special concern due to its association with adult-onset diseases. In this thesis project, the effect of ART on the genetic and epigenetic status of the placenta, and their associations with fetal growth restriction are examined.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Copies

Website

http://hdl.handle.net/2429/16421

Author

Astanehe, Arezoo

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2005

Subject

Faculty of Medicine

Theses

Abstract

n approximately 40% of ovarian cancers, PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) is amplified. This amplification correlates with increased PIK3CA transcription, p110α protein expression, and PI3K activity. Moreover, PIK3CA is implicated as an oncogene in ovarian cancers. Another common mutation in ovarian cancer leads to loss of p53 function. Alterations to p53 are known to be involved in tumour development and progression.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf