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Role of receptor tyrosine kinase regulator Sprouty in ovarian cancer cells

https://cwslc.andornot.com/en/permalink/catalog113944

So, Wai Kin. [Vancouver, BC?]: University of British Columbia , 2012.

Website: http://hdl.handle.net/2429/42242

Material Type: Thesis

Call Number: Thesis Shelf

Aberrant epidermal growth factor receptor (EGFR) activity contributes to the development of epithelial ovarian cancer (EOC), a common and lethal female malignancy. Elucidating the regulation of EGFR function will improve treatments for EOC and the survival of patients. This study aims to elucidate …

1 website

Website: http://hdl.handle.net/2429/42242

Author: So, Wai Kin

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 2012

Subject: Faculty of Medicine; Theses

Abstract: Aberrant epidermal growth factor receptor (EGFR) activity contributes to the development of epithelial ovarian cancer (EOC), a common and lethal female malignancy. Elucidating the regulation of EGFR function will improve treatments for EOC and the survival of patients. This study aims to elucidate the role of Sprouty (SPRY) proteins, which are EGFR regulators, in EOC.

Language: English

Material Type: Thesis

Call Number: Thesis Shelf

Websites

http://hdl.handle.net/2429/42242

Human gonadotropin-releasing hormone-II regulation in ovarian cancer : mechanisms and potential functional role

https://cwslc.andornot.com/en/permalink/catalog113953

Poon, Song Ling. [Vancouver, BC?]: University of British Columbia , 2010.

Website: http://hdl.handle.net/2429/30021

Material Type: Thesis

Call Number: Thesis Shelf

It is increasingly apparent that GnRH-II acts as an autocrine/paracrine regulator in non-pituitary tissues, in addition to its role in the regulation of gonadotropin synthesis, and is an important player in cancer cell biology. High levels of GnRH-II and GnRHR in malignant ovarian tumors as compare…

1 website

Website: http://hdl.handle.net/2429/30021

Author: Poon, Song Ling

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 2010

Subject: Faculty of Medicine; Theses

Abstract: It is increasingly apparent that GnRH-II acts as an autocrine/paracrine regulator in non-pituitary tissues, in addition to its role in the regulation of gonadotropin synthesis, and is an important player in cancer cell biology. High levels of GnRH-II and GnRHR in malignant ovarian tumors as compared with benign ovarian tissues underlies the importance of understanding GnRH-II function in ovarian cancer. In an attempt to define the regulation of GnRH-II in these tissues, we found that a cyclic-AMP responsive element (CRE) is critical for GnRH-II promoter transcription.

Language: English

Material Type: Thesis

Call Number: Thesis Shelf

Websites

http://hdl.handle.net/2429/30021