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5 records – page 1 of 1.

Expression and function of HOXA genes in the normal ovary and ovarian carcinoma

https://cwslc.andornot.com/en/permalink/catalog113963
Ota, Takayo. [Vancouver, BC?]: University of British Columbia , 2006.
Website
http://hdl.handle.net/2429/30974
Material Type
Thesis
Call Number
Thesis Shelf
Homeobox genes, which code for families of transcription factors, act at the top of genetic hierarchies. HOX genes specify positional identity during development, and in adult tissues, regulate differentiation and proliferation. Most ovarian carcinomas are derived from the ovarian surface epitheliu…
Website
http://hdl.handle.net/2429/30974
Author
Ota, Takayo
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2006
Subject
Faculty of Medicine
Theses
Abstract
Homeobox genes, which code for families of transcription factors, act at the top of genetic hierarchies. HOX genes specify positional identity during development, and in adult tissues, regulate differentiation and proliferation. Most ovarian carcinomas are derived from the ovarian surface epithelium (OSE). In contrast to other carcinomas, OSE differentiates further with neoplastic progression and acquires Mtillerian duct-derived epithelial properties. I tested the hypothesis that growth and differentiation in ovarian carcinogenesis are regulated by HOX genes.
Language
English
Material Type
Thesis
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Thesis Shelf
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Investigation of methylation and gene expression in placenta of pregnancies conceived by assisted reproductive technology (ART)

https://cwslc.andornot.com/en/permalink/catalog113947
Sakian, Sina. [Vancouver, BC?]: University of British Columbia , 2011.
Website
http://hdl.handle.net/2429/31191
Material Type
Thesis
Call Number
Thesis Shelf
With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures wi…
Website
http://hdl.handle.net/2429/31191
Author
Sakian, Sina
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2011
Subject
Faculty of Medicine
Theses
Abstract
With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures with increased incidence of low birth weight (LBW), chromosomal abnormalities, birth defects and imprinting disorders. No study has proposed a single defined cause for any of these defects in ART infants, however it is believed that they may be due to both the invasiveness of ART and to genetic defects that are at the root of the infertility in the parents. In this study, changes in the methylation of the H19 and IGF2 imprinting control region 1 (ICR1) were investigated for both ART (n=92) and naturally conceived controls (n=19) using pyrosequencing.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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The PIERS (Pre-eclampsia Integrated Estimate of RiSk) model : development of a valid outcome prediction model for pre-eclampsia.

https://cwslc.andornot.com/en/permalink/catalog113957
Menzies, Jennifer Marie. [Vancouver, BC?]: University of British Columbia , 2009.
Website
http://hdl.handle.net/2429/6844
Material Type
Thesis
Call Number
Thesis Shelf
Availability
1 copy, 1 available
This research responded to the need to define evidence-based criteria of maternal risk by developing a model - the Pre-eclampsia Integrated Estimate of RiSk (or PIERS) model ? that predicts a combined adverse maternal outcome (mortality and/or significant morbidities) within 48 hour of, and up to s…
Website
http://hdl.handle.net/2429/6844
Author
Menzies, Jennifer Marie
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2009
Subject
Faculty of Medicine
Theses
Abstract
This research responded to the need to define evidence-based criteria of maternal risk by developing a model - the Pre-eclampsia Integrated Estimate of RiSk (or PIERS) model ? that predicts a combined adverse maternal outcome (mortality and/or significant morbidities) within 48 hour of, and up to seven days after, admission with pre-eclampsia (study eligibility)
Language
English
Material Type
Thesis
Call Number
Thesis Shelf

Copies

Copy 1 BC Children's and Women's Study and Learning Commons Thesis Shelf Available
Websites
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Recombinant human activated protein C as a therapy for pre-eclampsia

https://cwslc.andornot.com/en/permalink/catalog113962
Peng, Gang. [Vancouver, BC?]: University of British Columbia , 2007.
Website
http://hdl.handle.net/2429/32051
Material Type
Thesis
Call Number
Thesis Shelf
Pre-eclampsia remains one of the most common causes of maternal mortality in the developed world, and we still have no known effective prophylaxis and proven modifiers. The recent successful clinical trial of recombinant human activated protein C (rhAPC) in the management of SIRS (systemic inflamma…
Website
http://hdl.handle.net/2429/32051
Author
Peng, Gang
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2007
Subject
Faculty of Medicine
Theses
Abstract
Pre-eclampsia remains one of the most common causes of maternal mortality in the developed world, and we still have no known effective prophylaxis and proven modifiers. The recent successful clinical trial of recombinant human activated protein C (rhAPC) in the management of SIRS (systemic inflammatory response syndrome) has drawn attention to the possible use of this medicine for other conditions. Pre-eclampsia, has remarkable similarity to SIRS and may be such a condition.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Regulated expression of aggrecanases of ADAMTS family in endometrial physiology and pathology

https://cwslc.andornot.com/en/permalink/catalog113954
Wen, Jiadi. [Vancouver, BC?]: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/30478
Material Type
Thesis
Call Number
Thesis Shelf
The ADAMTS (A Disintegrin and Metalloproteinase with TromboSpondin Repeats) are a novel family of secreted metalloproteinases. There is increasing evidence that distinct ADAMTS subtypes play key roles in embryonic development, reproduction and cancer. Nineteen ADAMTS subtypes have been identified i…
Website
http://hdl.handle.net/2429/30478
Author
Wen, Jiadi
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
The ADAMTS (A Disintegrin and Metalloproteinase with TromboSpondin Repeats) are a novel family of secreted metalloproteinases. There is increasing evidence that distinct ADAMTS subtypes play key roles in embryonic development, reproduction and cancer. Nineteen ADAMTS subtypes have been identified in humans but most of them have been characterized only at the structural level. ADAMTS-1, -4, -5, -8, -9 and -15 have been subclassified into a subfamily, known as aggrecanases, owing to their ability to cleave the important extracellular matrix components, versican and aggrecan.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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