Website

http://hdl.handle.net/2429/34980

Author

Chen, Junling

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2010

Subject

Faculty of Medicine

Theses

Abstract

Nuclear receptors including estrogen receptors (ERs) and progesterone receptors (PRs) are activated by their ligands as well as by signaling pathways in response to peptide hormones and growth factors. In gonadotrophs, gonadotropin releasing hormones (GnRHs) act via the GnRH receptor (GnRHR). Both GnRH-I and GnRH-II activate an estrogen response element (ERE)-driven luciferase reporter gene in LβT2 mouse pituitary cells, and GnRH-I is more potent in this regard.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/33832

Author

Chan Wong, Edgar Antonio

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2011

Subject

Faculty of Medicine

Theses

Abstract

In-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are two of the most common forms of assisted reproductive technologies (ARTs) used to treat human infertility. Presently, over two million children have been conceived by ART. The majority of these children are born healthy. However, IVF and ICSI have been associated with increased risks of adverse perinatal health outcomes. The higher risk of low birth weight, intrauterine growth restriction, and small for gestational age are of special concern due to its association with adult-onset diseases. In this thesis project, the effect of ART on the genetic and epigenetic status of the placenta, and their associations with fetal growth restriction are examined.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

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