Search Results - C&W Library Catalogue

Revise Search

Material Type

Language

Date

Author

Subject

Online Media Type

2 records – page 1 of 1.

Prev Next

Physical and functional interaction of p53 and p110a and implications in ovarian carcinogenesis

https://cwslc.andornot.com/en/permalink/catalog113967

Astanehe, Arezoo. [Vancouver, BC?]: University of British Columbia , 2005.

Website: http://hdl.handle.net/2429/16421

Material Type: Thesis

Call Number: Thesis Shelf

n approximately 40% of ovarian cancers, PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) is amplified. This amplification correlates with increased PIK3CA transcription, p110α protein expression, and PI3K activity. Moreover, PIK3CA is implicated as…

1 website

Website: http://hdl.handle.net/2429/16421

Author: Astanehe, Arezoo

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 2005

Subject: Faculty of Medicine; Theses

Abstract: n approximately 40% of ovarian cancers, PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) is amplified. This amplification correlates with increased PIK3CA transcription, p110α protein expression, and PI3K activity. Moreover, PIK3CA is implicated as an oncogene in ovarian cancers. Another common mutation in ovarian cancer leads to loss of p53 function. Alterations to p53 are known to be involved in tumour development and progression.