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DNA methylation at imprinted and non-imprinted genes in the sperm of men affected by severe male factor infertility

https://cwslc.andornot.com/en/permalink/catalog113950

Minor, Agata. [Vancouver, BC?]: University of British Columbia , 2010.

Website: http://hdl.handle.net/2429/29282

Material Type: Thesis

Call Number: Thesis Shelf

Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA met…

1 website

Website: http://hdl.handle.net/2429/29282

Author: Minor, Agata

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 2010

Subject: Faculty of Medicine; Theses

Abstract: Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA methylation would be present in the ejaculate and testicular sperm of men affected by severe male factor infertility compared to that in fertile control men. Furthermore, we hypothesized abnormal DNA methylation would also affect non-imprinted genes in the sperm of men affected by severe oligozoospermia.

Language: English

Material Type: Thesis

Call Number: Thesis Shelf

Websites

http://hdl.handle.net/2429/29282

Meiotic defects in infertile men

https://cwslc.andornot.com/en/permalink/catalog113960

Ferguson, Kyle Akira. [Vancouver, BC?]: University of British Columbia , 2008.

Website: http://hdl.handle.net/2429/1228

Material Type: Thesis

Call Number: Thesis Shelf

While the introduction of intracytoplasmic sperm injection (ICSI) has revolutionized the treatment of male infertility, concerns have been raised regarding the risk of chromosomal abnormalities in pregnancies derived from ICSI. Studies on sperm from infertile men have suggested that this population…

1 website

Website: http://hdl.handle.net/2429/1228

Author: Ferguson, Kyle Akira

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 2008

Subject: Faculty of Medicine; Theses

Abstract: While the introduction of intracytoplasmic sperm injection (ICSI) has revolutionized the treatment of male infertility, concerns have been raised regarding the risk of chromosomal abnormalities in pregnancies derived from ICSI. Studies on sperm from infertile men have suggested that this population may produce higher rates of aneuploid sperm. Thus, we hypothesized that defects in early meiotic events may contribute to both male infertility and the production of aneuploid sperm.

Language: English

Material Type: Thesis

Call Number: Thesis Shelf

Websites

http://hdl.handle.net/2429/1228

Clinical and endocrine responses to ovarian hyperstimulation in flare and and luteal gonadotropin-releasing hormone agonist (GnRHa) protocols

https://cwslc.andornot.com/en/permalink/catalog113958

Nguyen, Tuan-Anh T. [Vancouver, BC?]: University of British Columbia , 2008.

Website: http://hdl.handle.net/2429/1395

Material Type: Thesis

Call Number: Thesis Shelf

Due to the ?flare effect? associated with the flare protocol, variation in the degree of follicular maturation during stimulation may result in differences in follicle response as compared to the luteal protocol which is based on maximal pituitary suppression and synchronization of follicular matur…

1 website

Website: http://hdl.handle.net/2429/1395

Author: Nguyen, Tuan-Anh T

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 2008

Subject: Faculty of Medicine; Theses

Abstract: Due to the ?flare effect? associated with the flare protocol, variation in the degree of follicular maturation during stimulation may result in differences in follicle response as compared to the luteal protocol which is based on maximal pituitary suppression and synchronization of follicular maturation. In this study, besides other methods, Anti-Mullerian Hormone (AMH), a novel marker for ovarian reserve, was used as a tool to evaluate the ovarian responsiveness to stimulation.

Language: English

Material Type: Thesis

Call Number: Thesis Shelf

Websites

http://hdl.handle.net/2429/1395

Fish analysis of chromosomal aneuploidies in spermatozoa from severely infertile men undergoing intracytoplasmic sperm injection (ICSI)

https://cwslc.andornot.com/en/permalink/catalog113969

Gao, Haijun. [Vancouver, BC?]: University of British Columbia , 2004.

Website: http://hdl.handle.net/2429/16195

Material Type: Thesis

Call Number: Thesis Shelf

The association between subsets of male infertility, oligoasthenoteratozoospermia (OAT), obstructive azoospermic (OA), non-obstructive azoospermia (NOA), and increased risk of having chromosomal abnormalities in the sperm has not been investigated. Chromosomal aneuploidy in sperm will be systematic…

1 website

Website: http://hdl.handle.net/2429/16195

Author: Gao, Haijun

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 2004

Subject: Faculty of Medicine; Theses

Abstract: The association between subsets of male infertility, oligoasthenoteratozoospermia (OAT), obstructive azoospermic (OA), non-obstructive azoospermia (NOA), and increased risk of having chromosomal abnormalities in the sperm has not been investigated. Chromosomal aneuploidy in sperm will be systematically investigated by standard methods with large sample sizes required to present significance.

Language: English

Material Type: Thesis

Call Number: Thesis Shelf

Websites

http://hdl.handle.net/2429/16195