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4 records – page 1 of 1.

The effects of clomiphene citrate on ovarian function in rats

https://cwslc.andornot.com/en/permalink/catalog113993
Feng, Tian Bin. [Vancouver, BC?]: University of British Columbia , 1990.
Website
http://hdl.handle.net/2429/28984
Material Type
Thesis
Call Number
Thesis Shelf
In the present study, the effects of clomiphene citrate (CC) on ovulation, ovarian growth and ovarian steroidogenesis were examined. Ovulation in rats in response to PMSG was completely blocked by administration of three daily treatments of 1.0 mg CC/rat, but was restored by administration of hCG a…
Website
http://hdl.handle.net/2429/28984
Author
Feng, Tian Bin
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1990
Subject
Faculty of Medicine
Theses
Abstract
In the present study, the effects of clomiphene citrate (CC) on ovulation, ovarian growth and ovarian steroidogenesis were examined. Ovulation in rats in response to PMSG was completely blocked by administration of three daily treatments of 1.0 mg CC/rat, but was restored by administration of hCG as a preovulatory LH surge substitute. When the number of treatment days was reduced to two days, 1.0 mg of CC enhanced ovulation in response to PMSG, whereas treatment for one day with the same dose of CC did not affect ovulation.
Language
English
Material Type
Thesis
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The effects of the beta-adrenergic agonist, ritodrine, in the fetal lamb

https://cwslc.andornot.com/en/permalink/catalog114000
Van der Weyde, Marlene. [Vancouver, BC?]: University of British Columbia , 1990.
Website
http://hdl.handle.net/2429/30417
Material Type
Thesis
Call Number
Thesis Shelf
Ritodrine is a beta-adrenergic agonist commonly used to inhibit premature labor contractions in women. The primary goal of ritodrine tocolysis is to prolong gestation, however, other indications may include fetal distress. The purpose of the current study was to examine the metabolic and behavioral…
Website
http://hdl.handle.net/2429/30417
Author
Van der Weyde, Marlene
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1990
Subject
Faculty of Medicine
Theses
Abstract
Ritodrine is a beta-adrenergic agonist commonly used to inhibit premature labor contractions in women. The primary goal of ritodrine tocolysis is to prolong gestation, however, other indications may include fetal distress. The purpose of the current study was to examine the metabolic and behavioral effects of ritodrine in the fetus, using the chronically instrumented pregnant sheep as an experimental model. Ritodrine was infused continuously into 11 fetal lambs at a rate of 2.6 ug/minute for a period of 8, 12 or 24 hours. Samples were taken simultaneously at predetermined time periods from a fetal femoral artery, umbilical vein, maternal femoral artery and uterine vein for the analysis of fetal and maternal arterial and umbilical and uterine venous blood gases, acid-base status, hematocrit, ritodrine concentration, uterine and umbilical blood flow, and glucose, lactate and oxygen concentrations and fluxes.
Language
English
Material Type
Thesis
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A morphological investigation of the effects of pregnant mare serum gonadotrophin on oocyte maturation, fertilization and embryonic development in rats

https://cwslc.andornot.com/en/permalink/catalog113990
Britton, Ann Patricia. [Vancouver, BC?]: University of British Columbia , 1991.
Website
http://hdl.handle.net/2429/30962
Material Type
Thesis
Call Number
Thesis Shelf
A delicate balance of steroid and gonadotrophic hormones is essential for intrafollicular oocyte maturation and successful fertilization and embryonic development. Previous studies have demonstrated that a superovulatory dose of pregnant mare serum gonadotrophin (PMSG) has excessive gonadotrophic a…
Website
http://hdl.handle.net/2429/30962
Author
Britton, Ann Patricia
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1991
Subject
Faculty of Medicine
Theses
Abstract
A delicate balance of steroid and gonadotrophic hormones is essential for intrafollicular oocyte maturation and successful fertilization and embryonic development. Previous studies have demonstrated that a superovulatory dose of pregnant mare serum gonadotrophin (PMSG) has excessive gonadotrophic activity and alters intrafol1icular steroid hormone levels. In a series of four experiments, the morphology of oocytes and embryos retrieved from immature rats, treated with either a low or high dose of PMSG, and mature, cycling rats was compared to determine whether a superovulatory dose of PMSG has an adverse effect on oocyte maturation and subsequent fertilization and embryonic development in immature rats. Morphological criteria for the assessment of intraoviductal oocyte aging were established in the first experiment.
Language
English
Material Type
Thesis
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Prostaglandin F[sub 2a]-mediated luteolytic and luteotrophic effects on the human granulosa-luteal cell

https://cwslc.andornot.com/en/permalink/catalog113976
Vaananen, Jeffrey Eric. [Vancouver, BC?]: University of British Columbia , 1997.
Website
http://hdl.handle.net/2429/6811
Material Type
Thesis
Call Number
Thesis Shelf
These studies examined the effects of prostaglandin-F[sub 2a] (PGF[sub 2a]) on progesterone and 178-estradiol (estradiol) production, as well as DNA and PGF[sub 2a]-receptor (PGF[sub 2a]-R) mRNA levels, in the human granulosa-luteal cell (GLC). Additionally, the interactions of PGF[sub 2a] with hum…
Website
http://hdl.handle.net/2429/6811
Author
Vaananen, Jeffrey Eric
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1997
Subject
Faculty of Medicine
Theses
Abstract
These studies examined the effects of prostaglandin-F[sub 2a] (PGF[sub 2a]) on progesterone and 178-estradiol (estradiol) production, as well as DNA and PGF[sub 2a]-receptor (PGF[sub 2a]-R) mRNA levels, in the human granulosa-luteal cell (GLC). Additionally, the interactions of PGF[sub 2a] with human chorionic gonadotrophin (hCG), gonadotrophin-releasing hormone (GnRH) and prostaglandin E₂ (PGE₂) were examined, with respect to progesterone and estradiol production.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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