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Effects and mechanisms of growth differentiation factor 9 on activin A-regulated inhibin B and progesterone production in human granulosa cells

https://cwslc.andornot.com/en/permalink/catalog113951

Shi, Fengtao. [Vancouver, BC?]: University of British Columbia , 2010.

Website: http://hdl.handle.net/2429/28961

Material Type: Thesis

Call Number: Thesis Shelf

Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regul…

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Website: http://hdl.handle.net/2429/28961

Author: Shi, Fengtao

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 2010

Subject: Faculty of Medicine; Theses

Abstract: Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regulator of ovarian function, but its overall effects, particularly relating to activin A actions, are unknown. We examined the potential crosstalk between activin A and GDF9 in primary cultures of human granulosa-lutein (hGL) cells. Pretreatment of hGL cells with GDF9 for 24 h resulted in an increased expression of activin receptors and Smad2/3, and decreased inhibitory Smad7 activity. These effects were attenuated by BMP type II receptor ectodomain (BMPR2 ECD), a GDF9 antagonist.

Language: English

Material Type: Thesis

Call Number: Thesis Shelf

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http://hdl.handle.net/2429/28961