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2 records – page 1 of 1.

Influences of endocrine and autocrine factors in normal and neoplastic ovarian surface epithelium

https://cwslc.andornot.com/en/permalink/catalog113974
Choi, Kyung-Chul. [Vancouver, BC?]: University of British Columbia , 2001.
Website
http://hdl.handle.net/2429/13688
Material Type
Thesis
Call Number
Thesis Shelf
The common epithelial ovarian tumors appear to arise from the ovarian surface epithelium (OSE), which is a simple squamous-to-cuboidal meso^helium covering the ovary. The exact mechanism of ovarian tumorigenesis is not well known even though this disease is the most frequent cause of cancer death i…
More Information is Available
  1 website  
Website
http://hdl.handle.net/2429/13688
Author
Choi, Kyung-Chul
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2001
Subject
Faculty of Medicine
Theses
Abstract
The common epithelial ovarian tumors appear to arise from the ovarian surface epithelium (OSE), which is a simple squamous-to-cuboidal meso^helium covering the ovary. The exact mechanism of ovarian tumorigenesis is not well known even though this disease is the most frequent cause of cancer death in gynecological malignancies. Repeated ovulation contributes to neoplastic transformation of OSE, indicating that the process of healing ruptured OSE may contribute to the disease. Therefore, it has been hypothesized that endocrine and autocrine factors may influence the occurrence of ovarian tumors in women.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
http://hdl.handle.net/2429/13688
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Ligand-independent activation of steroid hormone receptors by gonadotropin-releasing hormone

https://cwslc.andornot.com/en/permalink/catalog113952
Chen, Junling. [Vancouver, BC?]: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/34980
Material Type
Thesis
Call Number
Thesis Shelf
Nuclear receptors including estrogen receptors (ERs) and progesterone receptors (PRs) are activated by their ligands as well as by signaling pathways in response to peptide hormones and growth factors. In gonadotrophs, gonadotropin releasing hormones (GnRHs) act via the GnRH receptor (GnRHR). Both …
More Information is Available
  1 website  
Website
http://hdl.handle.net/2429/34980
Author
Chen, Junling
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
Nuclear receptors including estrogen receptors (ERs) and progesterone receptors (PRs) are activated by their ligands as well as by signaling pathways in response to peptide hormones and growth factors. In gonadotrophs, gonadotropin releasing hormones (GnRHs) act via the GnRH receptor (GnRHR). Both GnRH-I and GnRH-II activate an estrogen response element (ERE)-driven luciferase reporter gene in LβT2 mouse pituitary cells, and GnRH-I is more potent in this regard.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
http://hdl.handle.net/2429/34980
Show Less