Website

http://hdl.handle.net/2429/44653

Author

Nguyen, Tuan-Anh Thi

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2013

Subject

Faculty of Medicine

Theses

Abstract

Human newborns exposed in utero to maternally administered SSRIs such as fluoxetine (FX) have an increased risk of adverse pregnancy outcomes including poor neonatal adaptation. This comprises respiratory difficulty, jitteriness, cyanosis when feeding and persists for several days after birth. Several potential mechanisms underlying these symptoms have been proposed: 1) acute toxicity to the drugs (i.e. serotonin syndrome), 2) withdrawal syndrome due to the sudden discontinuation of maternal-fetal placental drug transfer at birth or 3) an SSRIs-elicited alteration in fetal brain development. However, the actual mechanism has not been elucidated.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://www.cw.bc.ca/library/pdf/2013PeerNavigatorToolkit.pdf

Author

Kwong, Sandy

Place of Publication

[Vancouver, BC?]

Publisher

BC Cancer Agency

Publication Date

2013

Physical Description

Softcover: 27 p.

Subject

Cancer-Coping

Cancer

Abstract

This guide describes the principles and processes involved in the development of the Chinese Peer Navigator Program at the BC Cancer Agency, Vancouver Centre and the bilingual resources that are used with Chinese-speaking patients (Mandarin, Cantonese and English).

This program also reflects “best practice” standards and can be used for future groups or organizations who may wish to adapt it for future peer navigator programs.

Language

English

Chinese

Material Type

Book

Call Number

REF FE 220 CHI 2013

Copies

Website

http://hdl.handle.net/2429/29783

Author

Zou, Junxuan

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2010

Subject

Faculty of Medicine

Theses

Abstract

The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We examined the presence of ADAMTS in first trimester human placenta and only ADAMTS-12 was present in cultures of invasive extravillous cytotrophoblast (EVT) at significantly higher levels than in poorly invasive JEG-3 chorocarcinoma cells. Immunohistochemistry staining of chorionic villi derived from first trimester human placenta demonstrated that ADAMTS-12 was intensively immunolocalized in the cytotrophoblast layer but weakly immunolocalized in the poorly-invasive syncytial trophoblast layer.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/30021

Author

Poon, Song Ling

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2010

Subject

Faculty of Medicine

Theses

Abstract

It is increasingly apparent that GnRH-II acts as an autocrine/paracrine regulator in non-pituitary tissues, in addition to its role in the regulation of gonadotropin synthesis, and is an important player in cancer cell biology. High levels of GnRH-II and GnRHR in malignant ovarian tumors as compared with benign ovarian tissues underlies the importance of understanding GnRH-II function in ovarian cancer. In an attempt to define the regulation of GnRH-II in these tissues, we found that a cyclic-AMP responsive element (CRE) is critical for GnRH-II promoter transcription.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/43273

Author

Asghari Roodsari, Alaleh

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2012

Subject

Faculty of Medicine

Theses

Abstract

Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. We therefore undertook the following study to further assess the usefulness of metabolomic profiling ?spent? embryo culture medium using Raman spectroscopy. Methods: Patients undergoing IVF+/-ICSI treatment from the UBC Centre for Reproductive Health were recruited for study.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/28961

Author

Shi, Fengtao

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2010

Subject

Faculty of Medicine

Theses

Abstract

Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regulator of ovarian function, but its overall effects, particularly relating to activin A actions, are unknown. We examined the potential crosstalk between activin A and GDF9 in primary cultures of human granulosa-lutein (hGL) cells. Pretreatment of hGL cells with GDF9 for 24 h resulted in an increased expression of activin receptors and Smad2/3, and decreased inhibitory Smad7 activity. These effects were attenuated by BMP type II receptor ectodomain (BMPR2 ECD), a GDF9 antagonist.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://www.perinatalservicesbc.ca/Documents/Guidelines-Standards/Maternal/MentalHealthDisordersGuideline.pdf

Corporate Author

BC Reproductive Mental Health Program

Perinatal Services BC

Place of Publication

[Vancouver, BC?]

Publisher

BC Reproductive Mental Health

Publication Date

2014

Physical Description

Softcover: 90 p.

Subject

Pregnancy/Childbirth. Obstetrics

Mental Health/Illness

Prenatal Care

Mental Health

Anxiety

Abstract

These guidelines are designed to support healthcare clinicians with early detection and treatment of mental health disorders in pregnant and postpartum women.

The guidelines include:

• an overview of mental health disorders in the perinatal period;

• four common disorders: depression, anxiety disorders, bipolar disorder, and psychotic disorders, including postpartum psychosis; and

• education and prevention, screening and diagnosis, treatment, and recommendations for each disorder.

Notes

Please note that the version for sale is in BLACK & WHITE only.

Language

English

Material Type

Book

Call Number

REF GH 200 BCR 2014

Copies