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High performing healthcare systems: Delivering quality by design

https://cwslc.andornot.com/en/permalink/catalog110906
Baker, G. Ross, MacIntosh-Murray, Anu, Porcellato, Christina, Dionne, Lynn, Stelmacovich, Kim, Born, Karen. [Toronto, ON]: Longwoods Publishing Corporation , 2008.
Website
http://www.longwoods.com/home.php?cat=571
Material Type
Book
Call Number
REF JB 100 BAK 2008
Availability
1 copy, 1 available
An examination of leadership strategies, organizational processes and investments made to create and sustain improvement in healthcare.
Website
http://www.longwoods.com/home.php?cat=571
Website Notes
To read individual chapters online...click on the link above
Author
Baker, G. Ross
MacIntosh-Murray, Anu
Porcellato, Christina
Dionne, Lynn
Stelmacovich, Kim
Born, Karen
Place of Publication
[Toronto, ON]
Publisher
Longwoods Publishing Corporation
Publication Date
2008
Physical Description
Paperback: 292 pages.
Subject
Health Care Delivery Systems
Hospitals Services
Abstract
An examination of leadership strategies, organizational processes and investments made to create and sustain improvement in healthcare.
ISBN
9780981008905
Language
English
Material Type
Book
Call Number
REF JB 100 BAK 2008

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
Websites
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Communicating risks and benefits: An evidence-based user's guide

https://cwslc.andornot.com/en/permalink/catalog111871
Fischhoff, Baruch, Brewer, Noel T., Downs, Julie S.(eds.). Maryland, USA: FDA, US Department of Health & Human Services , 2011.
Website
http://www.cw.bc.ca/library/pdf/Risk communication book remediated2.pdf
Material Type
Book
Online
Effective risk communication is essential to the well-being of any organization and those people who depend on it. Ineffective communication can cost lives, money, and reputations. Communicating Risks and Benefits: An Evidence-Based User's Guide provides the scientific foundations for effective …
Website
http://www.cw.bc.ca/library/pdf/Risk communication book remediated2.pdf
Website Notes
Click on the link above to view/print.
Author
Fischhoff, Baruch
Brewer, Noel T.
Downs, Julie S.(eds.)
Corporate Author
Food & Drug Administration (FDA), US Department of Health & Human Services
Place of Publication
Maryland, USA
Publisher
FDA, US Department of Health & Human Services
Publication Date
2011
Physical Description
PDF file: 242 p.
Subject
Leadership/Coaching
Communication
Abstract
Effective risk communication is essential to the well-being of any organization and those people who depend on it. Ineffective communication can cost lives, money, and reputations. Communicating Risks and Benefits: An Evidence-Based User's Guide provides the scientific foundations for effective communication.
Language
English
Material Type
Book
Online
Websites
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Systematic approaches to a successful literature review

https://cwslc.andornot.com/en/permalink/catalog124764
Booth, Andrew, Papaioannou, Diana, Sutton, Anthea. Thousand Oaks, Calif.: Sage Publications , 2012.
Material Type
Book
Call Number
REF KT 100 BOO 2012
Availability
1 copy, 1 available
  1 image     1 document  
Author
Booth, Andrew
Papaioannou, Diana
Sutton, Anthea
Place of Publication
Thousand Oaks, Calif.
Publisher
Sage Publications
Publication Date
2012
Physical Description
279 p.
Subjects
Biomedical Research - methods
Writing
Review Literature as Topic
Evidence-based practice - methods
Meta-Analysis as Topic
Bibliography as Topic
Information Storage and Retrieval - methods
Information Services - organization & administration
ISBN
9780857021359
Language
English
Material Type
Book
Call Number
REF KT 100 BOO 2012

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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McWhinney's Textbook of Family Medicine

https://cwslc.andornot.com/en/permalink/catalog124769
Freeman, Thomas R. New York, NY: Oxford University Press , 2016. 4th Ed.
Material Type
Book
Call Number
REF FA 310 FRE 2016
Availability
1 copy, 1 available
Highly acclaimed in its first three editions, McWhinney's Textbook of Family Medicine is one of the seminal texts in the field. While many family medicine texts simply cover the disorders a practitioner might see in clinical practice, McWhinney's defines the principles and practices of family medic…
  1 image     1 document  
Author
Freeman, Thomas R.
Edition
4th Ed.
Place of Publication
New York, NY
Publisher
Oxford University Press
Publication Date
2016
Physical Description
520 pp
Subject
Family Medicine-Directories. Resource Guides
Medical Directories. Resource Guides
UBC MD Undergrad
Family Medicine
Abstract
Highly acclaimed in its first three editions, McWhinney's Textbook of Family Medicine is one of the seminal texts in the field. While many family medicine texts simply cover the disorders a practitioner might see in clinical practice, McWhinney's defines the principles and practices of family medicine as a separate and distinct field of practice. The fourth edition presents six new clinical chapters of common problems in family medicine: respiratory illness, musculoskeletal pain, depression, diabetes, obesity and multimorbidity. This new edition also provides information on stewardship of resources, patient information and data, delivery of care in the home, and consultation and referral. The volume also covers continuing advances in the research base of family medicine. Readers will come away with a deeper appreciation for the role of the generalist in healthcare.
ISBN
978-0199370689
Language
English
Material Type
Book
Call Number
REF FA 310 FRE 2016

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Documents

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Chinese cancer patient peer navigator toolkit: A model for language-based peer navigation

https://cwslc.andornot.com/en/permalink/catalog112530
Kwong, Sandy. [Vancouver, BC?]: BC Cancer Agency , 2013.
Website
http://www.cw.bc.ca/library/pdf/2013PeerNavigatorToolkit.pdf
Material Type
Book
Call Number
REF FE 220 CHI 2013
Availability
1 copy, 1 available
This guide describes the principles and processes involved in the development of the Chinese Peer Navigator Program at the BC Cancer Agency, Vancouver Centre and the bilingual resources that are used with Chinese-speaking patients (Mandarin, Cantonese and English).; This program also reflects “be…
  1 image     1 website  
Website
http://www.cw.bc.ca/library/pdf/2013PeerNavigatorToolkit.pdf
Author
Kwong, Sandy
Place of Publication
[Vancouver, BC?]
Publisher
BC Cancer Agency
Publication Date
2013
Physical Description
Softcover: 27 p.
Subject
Cancer-Coping
Cancer
Abstract
This guide describes the principles and processes involved in the development of the Chinese Peer Navigator Program at the BC Cancer Agency, Vancouver Centre and the bilingual resources that are used with Chinese-speaking patients (Mandarin, Cantonese and English).
This program also reflects “best practice” standards and can be used for future groups or organizations who may wish to adapt it for future peer navigator programs.
Language
English
Chinese
Material Type
Book
Call Number
REF FE 220 CHI 2013

Copies

Copy 1 BC Children's and Women's Study and Learning Commons Available
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Nature medicine

https://cwslc.andornot.com/en/permalink/catalog119779
Website
PHSA Users:
http://search.ebscohost.com/login.aspx?direct=true&db=edspub&AN=edp50997&site=pfi-live
UBC Users:
http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=AC_T_M&C=Nature+medicine
Alternate Title
Nat. Med.
Place of Publication
New York, NY
Publisher
Nature Publishing Group
Publication Date
1995 - Present.
ISSN
1078-8956
Language
English
Material Type
Serial
Frequency
Monthly
Holdings
CFRI/Study & Learning Commons - Print: v.1:1-v.11:7,10,12 (1995-2005); v.12:10 (2006); v.13:3 (2007); v.14:11+suppls. (2008).
Missing: v.1:2,5 (1995); v.4:1,2,6,8-12 (1998); v.5:1-6 (1999); v.6:8 (2000); v.11:8,9,11 (2005); v.12:1-11 (2006); v.13:1-2 (2007).
Online: 1995 to present.
Websites
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New England journal of medicine

https://cwslc.andornot.com/en/permalink/catalog119831
Website
PHSA Users:
http://search.ebscohost.com/login.aspx?direct=true&db=edspub&AN=edp51617&site=pfi-live
UBC Users:
http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=I_M&C=0028-4793
Alternate Title
NEJM
Place of Publication
[Boston, MA]
Publisher
Massachusetts Medical Society
Publication Date
1990 - Present.
ISSN
0028-4793
Language
English
Material Type
Serial
Frequency
Weekly
Holdings
CFRI/Study & Learning Commons - Print: v.330:20-v.365:17 (1994-2011).
Missing: v.331:10,12,14,15,19-21 (1994); v.332:20 (1995); v.334:13 (1996); v.337:14 (1997); v.338:2,4,12,22 (1998); v.341:16 (1999); v.342:all (2000); v.343:3,4,6-13,15-17,19,21-22,24-26 (2000); v.344:19-21,23,26; v.345:4,5,7-9,11-13,16,17,20-23,26 (2001); v.346:6-9,14,15,18-20,26 (2002); v.349:5-8,11,12,17,18,24 (2003); v.350:21 (2004); v.353:6,8-13,20 (2005); v.354:7,10,16; v.355:15,18,23 (2006); v.356:2,3,20; v.357:23 (2007); v.358:22,23; v.359:16,18 (2008); v.360:23; v.361:1,9-12 (2009); v.362:4; v.363:21 (2010).
Online: 1990 to present.
Websites
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Best practice guidelines for mental health disorders in the perinatal period

https://cwslc.andornot.com/en/permalink/catalog112945
BC Reproductive Mental Health Program, Perinatal Services BC. [Vancouver, BC?]: BC Reproductive Mental Health , 2014.
Website
http://www.perinatalservicesbc.ca/Documents/Guidelines-Standards/Maternal/MentalHealthDisordersGuideline.pdf
Material Type
Book
Call Number
REF GH 200 BCR 2014
Availability
1 copy, 1 available
These guidelines are designed to support healthcare clinicians with early detection and treatment of mental health disorders in pregnant and postpartum women.; The guidelines include:; • an overview of mental health disorders in the perinatal period;; • four common disorders: depression, …
  1 image     1 website  
Website
http://www.perinatalservicesbc.ca/Documents/Guidelines-Standards/Maternal/MentalHealthDisordersGuideline.pdf
Corporate Author
BC Reproductive Mental Health Program
Perinatal Services BC
Place of Publication
[Vancouver, BC?]
Publisher
BC Reproductive Mental Health
Publication Date
2014
Physical Description
Softcover: 90 p.
Subject
Pregnancy/Childbirth. Obstetrics
Mental Health/Illness
Prenatal Care
Mental Health
Anxiety
Abstract
These guidelines are designed to support healthcare clinicians with early detection and treatment of mental health disorders in pregnant and postpartum women.
The guidelines include:
• an overview of mental health disorders in the perinatal period;
• four common disorders: depression, anxiety disorders, bipolar disorder, and psychotic disorders, including postpartum psychosis; and
• education and prevention, screening and diagnosis, treatment, and recommendations for each disorder.
Notes
Please note that the version for sale is in BLACK & WHITE only.
Language
English
Material Type
Book
Call Number
REF GH 200 BCR 2014

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Interdisciplinary Pediatric Palliative Care

https://cwslc.andornot.com/en/permalink/catalog124766
Philadelphia, PA: Oxford , 2021. 2nd Ed.
Material Type
Book
Call Number
REF GK 100 WOL 2021
Availability
1 copy, 1 available
Interdisciplinary Pediatric Palliative Care provides a uniquely integrated, comprehensive resource about palliative care for seriously ill children and their families. The field of palliative care is based on the fundamental principle that an interdisciplinary team is optimal in caring for patients…
  1 image     1 document  
Editor
Wolfe, Joanne
Hinds, Pamela S.
Sourkes, Barbara S.
Edition
2nd Ed.
Place of Publication
Philadelphia, PA
Publisher
Oxford
Publication Date
2021
Physical Description
598 pp
Subject
Children's Health. Pediatrics
UBC MD Undergrad
Pediatrics
Palliative Care
Abstract
Interdisciplinary Pediatric Palliative Care provides a uniquely integrated, comprehensive resource about palliative care for seriously ill children and their families. The field of palliative care is based on the fundamental principle that an interdisciplinary team is optimal in caring for patients and their families throughout the illness trajectory. The text integrates themes including goals of care, discipline-specific roles, cultural and spiritual considerations, evidence-based outcomes, and far more. It emphasizes the value of words and high-quality communication in palliative care. Importantly, content acknowledges challenging periods between team members, and how those can ultimately benefit team, patient, and family care outcomes. Each chapter includes the perspective of the family of a seriously ill child in the form of a vignette to promote care team understanding of this crucial perspective. This second edition is founded on a wealth of evidence that reflects the innovations in pediatric palliative care science over the past 10 years, including initiatives in clinical care, research, and education. Interdisciplinary Pediatric Palliative Care is appropriate for all pediatric palliative clinicians (PPC), including physicians, nurses, psychosocial clinicians, chaplains, and many others. All subspecialists who deliver care to seriously ill children, will find this book a must-have for their work. Advance Praise for Interdisciplinary Pediatric Palliative Care, Second Edition "This new edition is as much a testament to pediatric palliative care's remarkable evolution as a field as it is a quintessential playbook for providing the high-quality holistic and compassionate care that families with seriously ill children desperately want. Every page thoughtfully weaves together how interprofessional teams can contribute collaboratively to learning about and supporting the preferences, needs and priorities of the precious patients and families in their circle of care. It is a must read for all practitioners to enhance their palliative care understanding, appreciation and ability as a foundation for optimizing quality of life in practice." - Rebecca Kirch, JD, Executive Vice President of Policy and Programs, National Patient Advocate Foundation "This book offers a truly contemporary and comprehensive view of the entire field of pediatric palliative care. The focus on social determinants of health, cultural humility, and disparities in care could not be timelier, and the section highlighting conflict and conflict resolution should be required reading. The continued and purposeful inclusion of interdisciplinary clinicians in producing each chapter models the palliative care team itself-an approach in which all voices are necessary as we seek to provide the most compassionate care possible." - Rachel Thienprayoon, MD, MSCS, FAAP, FAAHPM, Associate Professor of Anesthesia, Medical Director, StarShine Hospice and Palliative Care, Cincinnati Children's Hospital Medical Center
ISBN
978-019-009001-2
Language
English
Material Type
Book
Call Number
REF GK 100 WOL 2021

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Documents

Interdisciplinary Pediatric Palliative Care.jpg

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Clinical Genetics: An International Journal of Genetics, Molecular and Personalized Medicine

https://cwslc.andornot.com/en/permalink/catalog114754
Website
PHSA Users:
http://search.ebscohost.com/login.aspx?direct=true&db=edspub&AN=edp18084&site=pfi-live
UBC Users:
http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=AC_T_B&C=clinical+genetics
Place of Publication
Malden, Ma.
Publisher
John Wiley & Sons, Inc.
Publication Date
1970 - Present.
ISSN
0009-9163
Language
English
Material Type
Serial
Frequency
Monthly
Holdings
CFRI/Study & Learning Commons - Print: v.45:6-v.57:4+special issue (1994-2000); v.61:1 (2002); v.69:3-v.76:3 (2006-2009).
Missing: v.51:3, v.52:4 (1997); v.53:2 (1998); v.55:4, v.56:1,3 (1999); v.57:1-3, v.58:1-6 (2000); v.59:1-6, v.60:1-6 (2001); v.61:2-6, v.62:1-6 (2002); 2003-2005; v.69:1-2 (2006); v.73:3-5 (2008); v.75:1,3,4, v.76:2,4-6 (2009).
Online: 1970 to present.
Websites
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Canadian journal of rural medicine: The official journal of the Society of Rural Physicians of Canada

https://cwslc.andornot.com/en/permalink/catalog114596
Website
PHSA Users:
http://web.a.ebscohost.com/pfi/detail/detail?vid=15&sid=80dd29ce-f1c9-480f-93d5-346abac169f7%40sessionmgr4009&hid=4106&bdata=JnNpdGU9cGZpLWxpdmU%3d#AN=edp15358&db=edspub
UBC Users:
http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=AC_T_B&C=Canadian+journal+of+rural+medicine
Alternate Title
Canadian journal of rural medicine : the official journal of the Society of Rural Physicians of Canada = Journal canadien de la médecine rurale : le journal officiel de la Société de médecine rurale du Canada.
Corporate Author
Society of Rural Physicians of Canada
Place of Publication
[Ottawa, ON]
Publisher
Canadian Medical Association
Publication Date
1996 - Present
Notes
Articles in English; some are also in French.
ISSN
1203-7796
Language
English, French
Material Type
Serial
Frequency
Quarterly
Holdings
CFRI/Study & Learning Commons - Print:v.10:1-v.15:4 (2005-2010); v.16:3 (2011); v.17:1-2 (2012).
Missing: v.8:2-4 (2003); v.9:1-4 (2004); v.11:4 (2006); v.12:4 (2007); v.13:2 (2008).
Online: 1996 to present.
Websites
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Profiling the vaginal microbiome in HIV-positive women

https://cwslc.andornot.com/en/permalink/catalog113942
Mahal, Daljeet Singh. [Vancouver, BC?]: University of British Columbia , 2013.
Website
http://hdl.handle.net/2429/44267
Material Type
Thesis
Call Number
Thesis Shelf
Disruptions or imbalances of the vaginal microbiome can lead to negative reproductive health consequences for women, including an increased risk of sexually transmitted infections, pelvic inflammatory disease, and preterm birth. HIV-positive women may be particularly vulnerable to microbiome disrup…
Website
http://hdl.handle.net/2429/44267
Author
Mahal, Daljeet Singh
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2013
Subject
Faculty of Medicine
Theses
Abstract
Disruptions or imbalances of the vaginal microbiome can lead to negative reproductive health consequences for women, including an increased risk of sexually transmitted infections, pelvic inflammatory disease, and preterm birth. HIV-positive women may be particularly vulnerable to microbiome disruptions due to the immune dysfunction intrinsic to this disease. The objective of this study was to explore the vaginal microbiome in HIV-positive reproductive-aged women utilizing cpn60 metagenomic profiling and to correlate vaginal bacterial profiles with demographic/clinical variables.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Cardiovascular, metabolic, endocrine and behavioral aspects of development in postnatal lambs in relation to age, sex, lamb number and acute fluoxetine administration

https://cwslc.andornot.com/en/permalink/catalog113943
Nguyen, Tuan-Anh Thi. [Vancouver, BC?]: University of British Columbia , 2013.
Website
http://hdl.handle.net/2429/44653
Material Type
Thesis
Call Number
Thesis Shelf
Human newborns exposed in utero to maternally administered SSRIs such as fluoxetine (FX) have an increased risk of adverse pregnancy outcomes including poor neonatal adaptation. This comprises respiratory difficulty, jitteriness, cyanosis when feeding and persists for several days after birth. Seve…
Website
http://hdl.handle.net/2429/44653
Author
Nguyen, Tuan-Anh Thi
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2013
Subject
Faculty of Medicine
Theses
Abstract
Human newborns exposed in utero to maternally administered SSRIs such as fluoxetine (FX) have an increased risk of adverse pregnancy outcomes including poor neonatal adaptation. This comprises respiratory difficulty, jitteriness, cyanosis when feeding and persists for several days after birth. Several potential mechanisms underlying these symptoms have been proposed: 1) acute toxicity to the drugs (i.e. serotonin syndrome), 2) withdrawal syndrome due to the sudden discontinuation of maternal-fetal placental drug transfer at birth or 3) an SSRIs-elicited alteration in fetal brain development. However, the actual mechanism has not been elucidated.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Role of receptor tyrosine kinase regulator Sprouty in ovarian cancer cells

https://cwslc.andornot.com/en/permalink/catalog113944
So, Wai Kin. [Vancouver, BC?]: University of British Columbia , 2012.
Website
http://hdl.handle.net/2429/42242
Material Type
Thesis
Call Number
Thesis Shelf
Aberrant epidermal growth factor receptor (EGFR) activity contributes to the development of epithelial ovarian cancer (EOC), a common and lethal female malignancy. Elucidating the regulation of EGFR function will improve treatments for EOC and the survival of patients. This study aims to elucidate …
Website
http://hdl.handle.net/2429/42242
Author
So, Wai Kin
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2012
Subject
Faculty of Medicine
Theses
Abstract
Aberrant epidermal growth factor receptor (EGFR) activity contributes to the development of epithelial ovarian cancer (EOC), a common and lethal female malignancy. Elucidating the regulation of EGFR function will improve treatments for EOC and the survival of patients. This study aims to elucidate the role of Sprouty (SPRY) proteins, which are EGFR regulators, in EOC.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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X-chromosome inactivation and FMR1 CGG repeat and AGG interspersion number in female newborns conceived by assisted reproductive technologies (ARTs)

https://cwslc.andornot.com/en/permalink/catalog113945
Wu, Elizabeth Xianshi. [Vancouver, BC?]: University of British Columbia , 2012.
Website
http://hdl.handle.net/2429/42609
Material Type
Thesis
Call Number
Thesis Shelf
Pregnancies derived from in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with increased rates of chromosome abnormalities, congenital malformations, low birth weight, pre-term births, multiple gestations, and imprinting disorders. Assisted reproductive techno…
Website
http://hdl.handle.net/2429/42609
Author
Wu, Elizabeth Xianshi
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2012
Subject
Faculty of Medicine
Theses
Abstract
Pregnancies derived from in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with increased rates of chromosome abnormalities, congenital malformations, low birth weight, pre-term births, multiple gestations, and imprinting disorders. Assisted reproductive technologies (ARTs) enable sub-fertile individuals to circumvent the natural selective pressures involved in human reproduction. The risks of ARTs may be due to the underlying causes of subfertility in these individuals or to the artificial processes used to achieve pregnancy. X-chromosome inactivation (XCI) may be at risk to perturbations in ARTs as it is thought to occur during the blastocyst stage when in vitro culturing would be taking place. We examined the XCI status in females conceived by ICSI (n=70), IVF (n=68), and naturally (NC, n=42).
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Noninvasive assessment of embryo quality in human in vitro fertilization : metabolomic profiling of embryo culture media with Raman spectroscopy

https://cwslc.andornot.com/en/permalink/catalog113946
Asghari Roodsari, Alaleh. [Vancouver, BC?]: University of British Columbia , 2012.
Website
http://hdl.handle.net/2429/43273
Material Type
Thesis
Call Number
Thesis Shelf
Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. …
Website
http://hdl.handle.net/2429/43273
Author
Asghari Roodsari, Alaleh
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2012
Subject
Faculty of Medicine
Theses
Abstract
Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. We therefore undertook the following study to further assess the usefulness of metabolomic profiling ?spent? embryo culture medium using Raman spectroscopy. Methods: Patients undergoing IVF+/-ICSI treatment from the UBC Centre for Reproductive Health were recruited for study.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Investigation of methylation and gene expression in placenta of pregnancies conceived by assisted reproductive technology (ART)

https://cwslc.andornot.com/en/permalink/catalog113947
Sakian, Sina. [Vancouver, BC?]: University of British Columbia , 2011.
Website
http://hdl.handle.net/2429/31191
Material Type
Thesis
Call Number
Thesis Shelf
With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures wi…
Website
http://hdl.handle.net/2429/31191
Author
Sakian, Sina
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2011
Subject
Faculty of Medicine
Theses
Abstract
With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures with increased incidence of low birth weight (LBW), chromosomal abnormalities, birth defects and imprinting disorders. No study has proposed a single defined cause for any of these defects in ART infants, however it is believed that they may be due to both the invasiveness of ART and to genetic defects that are at the root of the infertility in the parents. In this study, changes in the methylation of the H19 and IGF2 imprinting control region 1 (ICR1) were investigated for both ART (n=92) and naturally conceived controls (n=19) using pyrosequencing.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Regulation of androgen action by sex hormone-binding globulin

https://cwslc.andornot.com/en/permalink/catalog113948
Hong, Eui-ju. [Vancouver, BC?]: University of British Columbia , 2011.
Website
http://hdl.handle.net/2429/35861
Material Type
Thesis
Call Number
Thesis Shelf
Sex hormone-binding globulin (SHBG) binds androgens and estrogens with high affinity, and regulates the distribution of these sex steroids in the blood and other biological fluids. Liver is the primary site of SHBG production, but the human SHBG transcription unit responsible for this is also expre…
Website
http://hdl.handle.net/2429/35861
Author
Hong, Eui-ju
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2011
Subject
Faculty of Medicine
Theses
Abstract
Sex hormone-binding globulin (SHBG) binds androgens and estrogens with high affinity, and regulates the distribution of these sex steroids in the blood and other biological fluids. Liver is the primary site of SHBG production, but the human SHBG transcription unit responsible for this is also expressed in proximal convoluted tubule (PCT) epithelial cells in a transgenic mouse model. Unlike hepatocytes which actively secrete SHBG and retain little immunoreactive SHBG within their cytoplasm, an incompletely glycosylated SHBG isoform has been found to accumulate inside PCT cells. These cells are androgen target cells, and the presence of SHBG within them accentuates androgen-dependent regulation of gene expression mediated by the androgen receptor (AR).
Language
English
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The characterization of ADAMTS-12 in the regulation of human trophoblast invasion in vitro

https://cwslc.andornot.com/en/permalink/catalog113949
Zou, Junxuan. [Vancouver, BC?]: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/29783
Material Type
Thesis
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The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We ex…
Website
http://hdl.handle.net/2429/29783
Author
Zou, Junxuan
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We examined the presence of ADAMTS in first trimester human placenta and only ADAMTS-12 was present in cultures of invasive extravillous cytotrophoblast (EVT) at significantly higher levels than in poorly invasive JEG-3 chorocarcinoma cells. Immunohistochemistry staining of chorionic villi derived from first trimester human placenta demonstrated that ADAMTS-12 was intensively immunolocalized in the cytotrophoblast layer but weakly immunolocalized in the poorly-invasive syncytial trophoblast layer.
Language
English
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