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Single cell studies of calcium as second messenger in human granulosa-lutein and embryonic kidney 293 cells

https://cwslc.andornot.com/en/permalink/catalog113979

Lee, Pearly S.N. [Vancouver, BC?]: University of British Columbia , 1999.

Website: http://hdl.handle.net/2429/10789

Material Type: Thesis

Call Number: Thesis Shelf

It is well established that LH action is mediated primarily by adenylate cyclase/cAMP. Conversely, the role of inositol phosphate/calcium in LH signalling has only recently been investigated. We examined the effects of gonadotrophins on intracellular calcium mobilisation in HEK293 cells transiently…

1 website

Website: http://hdl.handle.net/2429/10789

Author: Lee, Pearly S.N.

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 1999

Subject: Faculty of Medicine; Theses

Abstract: It is well established that LH action is mediated primarily by adenylate cyclase/cAMP. Conversely, the role of inositol phosphate/calcium in LH signalling has only recently been investigated. We examined the effects of gonadotrophins on intracellular calcium mobilisation in HEK293 cells transiently transfected with human wild type or chimeric gonadotrophs receptors (n=3400). Intracellular free calcium concentration was measured using fura-2 microspectrofluorimetric techniques. Human LH (2-4 μg/ml) arid CG (10 IU/ml) consistently evoked oscillatory calcium signals in HEK293 cells transfected with hLHr, whereas hFSH (2-4 μg/ml) failed to elicit any calcium responses.

Language: English

Material Type: Thesis

Call Number: Thesis Shelf

Websites

http://hdl.handle.net/2429/10789

The effects of clomiphene citrate on ovarian function in rats

https://cwslc.andornot.com/en/permalink/catalog113993

Feng, Tian Bin. [Vancouver, BC?]: University of British Columbia , 1990.

Website: http://hdl.handle.net/2429/28984

Material Type: Thesis

Call Number: Thesis Shelf

In the present study, the effects of clomiphene citrate (CC) on ovulation, ovarian growth and ovarian steroidogenesis were examined. Ovulation in rats in response to PMSG was completely blocked by administration of three daily treatments of 1.0 mg CC/rat, but was restored by administration of hCG a…

1 website

Website: http://hdl.handle.net/2429/28984

Author: Feng, Tian Bin

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 1990

Subject: Faculty of Medicine; Theses

Abstract: In the present study, the effects of clomiphene citrate (CC) on ovulation, ovarian growth and ovarian steroidogenesis were examined. Ovulation in rats in response to PMSG was completely blocked by administration of three daily treatments of 1.0 mg CC/rat, but was restored by administration of hCG as a preovulatory LH surge substitute. When the number of treatment days was reduced to two days, 1.0 mg of CC enhanced ovulation in response to PMSG, whereas treatment for one day with the same dose of CC did not affect ovulation.

Language: English

Material Type: Thesis

Call Number: Thesis Shelf

Websites

http://hdl.handle.net/2429/28984