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2 records – page 1 of 1.

Single cell studies of calcium as second messenger in human granulosa-lutein and embryonic kidney 293 cells

https://cwslc.andornot.com/en/permalink/catalog113979
Lee, Pearly S.N. [Vancouver, BC?]: University of British Columbia , 1999.
Website
http://hdl.handle.net/2429/10789
Material Type
Thesis
Call Number
Thesis Shelf
It is well established that LH action is mediated primarily by adenylate cyclase/cAMP. Conversely, the role of inositol phosphate/calcium in LH signalling has only recently been investigated. We examined the effects of gonadotrophins on intracellular calcium mobilisation in HEK293 cells transiently…
More Information is Available
  1 website  
Website
http://hdl.handle.net/2429/10789
Author
Lee, Pearly S.N.
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1999
Subject
Faculty of Medicine
Theses
Abstract
It is well established that LH action is mediated primarily by adenylate cyclase/cAMP. Conversely, the role of inositol phosphate/calcium in LH signalling has only recently been investigated. We examined the effects of gonadotrophins on intracellular calcium mobilisation in HEK293 cells transiently transfected with human wild type or chimeric gonadotrophs receptors (n=3400). Intracellular free calcium concentration was measured using fura-2 microspectrofluorimetric techniques. Human LH (2-4 μg/ml) arid CG (10 IU/ml) consistently evoked oscillatory calcium signals in HEK293 cells transfected with hLHr, whereas hFSH (2-4 μg/ml) failed to elicit any calcium responses.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
http://hdl.handle.net/2429/10789
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The ontogeny of acyl coenzyme A: cholesterol acyltransferase in rat liver, intestine, adipose tissue, and aorta

https://cwslc.andornot.com/en/permalink/catalog113994
Little, Marie-Terese E. [Vancouver, BC?]: University of British Columbia , 1990.
Website
http://hdl.handle.net/2429/29416
Material Type
Thesis
Call Number
Thesis Shelf
Epidemiological studies have shown that cholesterol is a major risk factor for the development of atherosclerosis. Since the atherosclerotic plaque develops over a long period interventions early in life may be of some benefit. In addition, it has been shown that the enzymes involved in cholesterol…
More Information is Available
  1 website  
Website
http://hdl.handle.net/2429/29416
Author
Little, Marie-Terese E.
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1990
Subject
Faculty of Medicine
Theses
Abstract
Epidemiological studies have shown that cholesterol is a major risk factor for the development of atherosclerosis. Since the atherosclerotic plaque develops over a long period interventions early in life may be of some benefit. In addition, it has been shown that the enzymes involved in cholesterol metabolism can be manipulated in early life. Therefore, studies of the developmental patterns of the key enzymes in cholesterol metabolism are of great importance. Acyl coenzyme A: cholesterol acyltransferase (ACAT) is the primary enzyme which catalyzes the conversion of free cholesterol to cholesterol esters in cells.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
http://hdl.handle.net/2429/29416
Show Less