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7 records – page 1 of 1.

Investigation of methylation and gene expression in placenta of pregnancies conceived by assisted reproductive technology (ART)

https://cwslc.andornot.com/en/permalink/catalog113947
Sakian, Sina. [Vancouver, BC?]: University of British Columbia , 2011.
Website
http://hdl.handle.net/2429/31191
Material Type
Thesis
Call Number
Thesis Shelf
With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures wi…
Website
http://hdl.handle.net/2429/31191
Author
Sakian, Sina
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2011
Subject
Faculty of Medicine
Theses
Abstract
With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures with increased incidence of low birth weight (LBW), chromosomal abnormalities, birth defects and imprinting disorders. No study has proposed a single defined cause for any of these defects in ART infants, however it is believed that they may be due to both the invasiveness of ART and to genetic defects that are at the root of the infertility in the parents. In this study, changes in the methylation of the H19 and IGF2 imprinting control region 1 (ICR1) were investigated for both ART (n=92) and naturally conceived controls (n=19) using pyrosequencing.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Noninvasive assessment of embryo quality in human in vitro fertilization : metabolomic profiling of embryo culture media with Raman spectroscopy

https://cwslc.andornot.com/en/permalink/catalog113946
Asghari Roodsari, Alaleh. [Vancouver, BC?]: University of British Columbia , 2012.
Website
http://hdl.handle.net/2429/43273
Material Type
Thesis
Call Number
Thesis Shelf
Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. …
Website
http://hdl.handle.net/2429/43273
Author
Asghari Roodsari, Alaleh
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2012
Subject
Faculty of Medicine
Theses
Abstract
Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. We therefore undertook the following study to further assess the usefulness of metabolomic profiling ?spent? embryo culture medium using Raman spectroscopy. Methods: Patients undergoing IVF+/-ICSI treatment from the UBC Centre for Reproductive Health were recruited for study.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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DNA methylation at imprinted and non-imprinted genes in the sperm of men affected by severe male factor infertility

https://cwslc.andornot.com/en/permalink/catalog113950
Minor, Agata. [Vancouver, BC?]: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/29282
Material Type
Thesis
Call Number
Thesis Shelf
Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA met…
Website
http://hdl.handle.net/2429/29282
Author
Minor, Agata
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA methylation would be present in the ejaculate and testicular sperm of men affected by severe male factor infertility compared to that in fertile control men. Furthermore, we hypothesized abnormal DNA methylation would also affect non-imprinted genes in the sperm of men affected by severe oligozoospermia.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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X-chromosome inactivation and FMR1 CGG repeat and AGG interspersion number in female newborns conceived by assisted reproductive technologies (ARTs)

https://cwslc.andornot.com/en/permalink/catalog113945
Wu, Elizabeth Xianshi. [Vancouver, BC?]: University of British Columbia , 2012.
Website
http://hdl.handle.net/2429/42609
Material Type
Thesis
Call Number
Thesis Shelf
Pregnancies derived from in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with increased rates of chromosome abnormalities, congenital malformations, low birth weight, pre-term births, multiple gestations, and imprinting disorders. Assisted reproductive techno…
Website
http://hdl.handle.net/2429/42609
Author
Wu, Elizabeth Xianshi
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2012
Subject
Faculty of Medicine
Theses
Abstract
Pregnancies derived from in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with increased rates of chromosome abnormalities, congenital malformations, low birth weight, pre-term births, multiple gestations, and imprinting disorders. Assisted reproductive technologies (ARTs) enable sub-fertile individuals to circumvent the natural selective pressures involved in human reproduction. The risks of ARTs may be due to the underlying causes of subfertility in these individuals or to the artificial processes used to achieve pregnancy. X-chromosome inactivation (XCI) may be at risk to perturbations in ARTs as it is thought to occur during the blastocyst stage when in vitro culturing would be taking place. We examined the XCI status in females conceived by ICSI (n=70), IVF (n=68), and naturally (NC, n=42).
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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The characterization of ADAMTS-12 in the regulation of human trophoblast invasion in vitro

https://cwslc.andornot.com/en/permalink/catalog113949
Zou, Junxuan. [Vancouver, BC?]: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/29783
Material Type
Thesis
Call Number
Thesis Shelf
The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We ex…
Website
http://hdl.handle.net/2429/29783
Author
Zou, Junxuan
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We examined the presence of ADAMTS in first trimester human placenta and only ADAMTS-12 was present in cultures of invasive extravillous cytotrophoblast (EVT) at significantly higher levels than in poorly invasive JEG-3 chorocarcinoma cells. Immunohistochemistry staining of chorionic villi derived from first trimester human placenta demonstrated that ADAMTS-12 was intensively immunolocalized in the cytotrophoblast layer but weakly immunolocalized in the poorly-invasive syncytial trophoblast layer.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Manual of high-risk pregnancy & delivery

https://cwslc.andornot.com/en/permalink/catalog119899
Gilbert, Elizabeth Stepp. [St. Louis, MO]: Mosby/Elsevier , 2011. 5th ed.
Material Type
Book
Call Number
EB 800 GIL 2011
Availability
15 copies, 12 available
The only book of its kind,Manual of High Risk Pregnancy & Delivery provides a complete resource for care of this special patient and her complex needs. It helps you provide positive outcomes with coverage of today's newest technology, physiologic considerations, psychologic implications, health dis…
Author
Gilbert, Elizabeth Stepp
Edition
5th ed
Place of Publication
[St. Louis, MO]
Publisher
Mosby/Elsevier
Publication Date
2011
Physical Description
paperback, 727 p., ill
Subjects
Pregnancy Complications--nursing
Pregnancy, High-risk
Obstetrical nursing - methods
Neonatal nursing - methods
Maternity nursing - Handbooks, manuals, etc.
Labor Complications
Abstract
The only book of its kind,Manual of High Risk Pregnancy & Delivery provides a complete resource for care of this special patient and her complex needs. It helps you provide positive outcomes with coverage of today's newest technology, physiologic considerations, psychologic implications, health disorders, and other complications in pregnancy. Written by noted educator and practitioner Elizabeth Stepp Gilbert, RNC, MS, FNP-BC, CNS, this book also describes how to screen for risk factors, provide preventive management, and intervene appropriately when problems arise. It's a concise, hands-on reference for both inpatient and outpatient settings!
ISBN
9780323072533
Language
English
Material Type
Book
Call Number
EB 800 GIL 2011

Copies

Copy 1 BC Children's and Women's Study and Learning Commons Missing On Loan, due Wednesday, June 5, 2019
Copy 9 BC Children's and Women's Study and Learning Commons On Loan, due Wednesday, December 11, 2019
Copy 10 BC Children's and Women's Study and Learning Commons On Loan, due Thursday, April 29, 2021
Copy 2 BC Children's and Women's Study and Learning Commons Available
Copy 3 BC Children's and Women's Study and Learning Commons Available
Copy 4 BC Children's and Women's Study and Learning Commons Available
Copy 5 BC Children's and Women's Study and Learning Commons Available
Copy 6 BC Children's and Women's Study and Learning Commons Available
Copy 7 BC Children's and Women's Study and Learning Commons Available
Copy 8 BC Children's and Women's Study and Learning Commons Available
Copy 11 BC Children's and Women's Study and Learning Commons Available
Copy 12 BC Children's and Women's Study and Learning Commons Available
Copy 13 BC Children's and Women's Study and Learning Commons Available
Copy 14 BC Children's and Women's Study and Learning Commons Available
Copy 15 BC Children's and Women's Study and Learning Commons Available
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Insulin adjustment for pregnancy: Self-directed learning module

https://cwslc.andornot.com/en/permalink/catalog108807
Kozak, Sharon, Learning & Development, Children's & Women's Health Centre of BC. [Vancouver, BC?]: Children's & Women's Health Centre of BC , 2010.
Material Type
Book
Call Number
REF GH 100 KOZ 2010
Availability
1 copy, 1 available
Written by a Prenatal Clinical Ecucator, this module assists registered nurses working in the Diabetes in Pregnancy Clinic to acquire the necessary knowledge in order to perform insulin adjustment in pregnancy. This is intended as an introduction, and must be complemented by supervised clinical exp…
Author
Kozak, Sharon
Learning & Development, Children's & Women's Health Centre of BC
Place of Publication
[Vancouver, BC?]
Publisher
Children's & Women's Health Centre of BC
Publication Date
2010
Physical Description
Spiral bound paperback: 88 pages
Subject
Pregnancy/Childbirth. Obstetrics
Insulin
Diabetes Mellitus
Diabetes
Nursing
Abstract
Written by a Prenatal Clinical Ecucator, this module assists registered nurses working in the Diabetes in Pregnancy Clinic to acquire the necessary knowledge in order to perform insulin adjustment in pregnancy. This is intended as an introduction, and must be complemented by supervised clinical experience, as per hospital policy.
Language
English
Material Type
Book
Call Number
REF GH 100 KOZ 2010

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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7 records – page 1 of 1.