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20 records – page 1 of 1.

Directory of self-help and peer support groups in the Lower Mainland

https://cwslc.andornot.com/en/permalink/catalog110014
Self-Help Resource Association of BC. [Vancouver, BC?]: Self-Help Resource Association of BC , 2007. 15th.
Website
http://www.selfhelpresource.bc.ca
Material Type
Book
Call Number
REF AA 22 SHRA 2007
Availability
1 copy, 1 available
Listing of self-help/support groups with offices in Greater Vancouver. Listed alphabetically with the address, telephone number and a brief description of the organization. Includes index.
Website
http://www.selfhelpresource.bc.ca
Corporate Author
Self-Help Resource Association of BC
Edition
15th
Place of Publication
[Vancouver, BC?]
Publisher
Self-Help Resource Association of BC
Publication Date
2007
Physical Description
Paperback: 133 p.
Subject
Directories. Resource Guides
Abstract
Listing of self-help/support groups with offices in Greater Vancouver. Listed alphabetically with the address, telephone number and a brief description of the organization. Includes index.
Language
English
Material Type
Book
Call Number
REF AA 22 SHRA 2007

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Regulated expression of aggrecanases of ADAMTS family in endometrial physiology and pathology

https://cwslc.andornot.com/en/permalink/catalog113954
Wen, Jiadi. [Vancouver, BC?]: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/30478
Material Type
Thesis
Call Number
Thesis Shelf
The ADAMTS (A Disintegrin and Metalloproteinase with TromboSpondin Repeats) are a novel family of secreted metalloproteinases. There is increasing evidence that distinct ADAMTS subtypes play key roles in embryonic development, reproduction and cancer. Nineteen ADAMTS subtypes have been identified i…
Website
http://hdl.handle.net/2429/30478
Author
Wen, Jiadi
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
The ADAMTS (A Disintegrin and Metalloproteinase with TromboSpondin Repeats) are a novel family of secreted metalloproteinases. There is increasing evidence that distinct ADAMTS subtypes play key roles in embryonic development, reproduction and cancer. Nineteen ADAMTS subtypes have been identified in humans but most of them have been characterized only at the structural level. ADAMTS-1, -4, -5, -8, -9 and -15 have been subclassified into a subfamily, known as aggrecanases, owing to their ability to cleave the important extracellular matrix components, versican and aggrecan.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Pediatric drug dosage guidelines

https://cwslc.andornot.com/en/permalink/catalog112175
Esau, Roberta (ed.). [Vancouver, BC?]: BC Children's Hospital , 2012. 6th Ed.
Website
http://www.pedmed.org/DrugApp/index.html
Material Type
Book
Call Number
REF EA 22 ESA 2012
Availability
1 copy, 1 available
The 6th edition of the BC Children's Hospital Pediatric Drug Dosage Guidelines provides dosing information for the pediatric population (neonates, infants and older children.) Also included are immunization schedules, guidance for therapeutic drug monitoring and protocols for anticoagulant and thro…
  1 image     1 website  
Website
http://www.pedmed.org/DrugApp/index.html
Author
Esau, Roberta (ed.)
Corporate Author
Pharmacy, Therapeutics and Nutrition Committee
Edition
6th Ed.
Place of Publication
[Vancouver, BC?]
Publisher
BC Children's Hospital
Publication Date
2012
Physical Description
Spiral bound softcover: 344 p.
Subject
Pharmacist
Drug Therapy-Children
Drugs-Directories. Resource Guides
Abstract
The 6th edition of the BC Children's Hospital Pediatric Drug Dosage Guidelines provides dosing information for the pediatric population (neonates, infants and older children.) Also included are immunization schedules, guidance for therapeutic drug monitoring and protocols for anticoagulant and thrombolytic therapy. Pediatrics, pediatric residents and fellows, pharmacists, pediatric nurses and other practitioners who treat children will find the guidelines a source of information on medications in children.
Language
English
Material Type
Book
Call Number
REF EA 22 ESA 2012

Copies

Copy 1 BC Children's and Women's Study and Learning Commons Available
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Learning healthcare system: Workshop summary (IOM Roundtable on Evidence-Based Medicine)

https://cwslc.andornot.com/en/permalink/catalog113231
Olsen, LeighAnne;, Aisner, Dara;, McGinnis, J. Michael (Eds). Washington, DC: National Academies Press , 2007.
Website
http://www.nap.edu/catalog.php?record_id=11903
Material Type
Online
This book considers how health care is structured to develop and to apply evidence--from health profession training and infrastructure development to advances in research methodology, patient engagement, payment schemes, and measurement--and highlights opportunities for the creation of a sustainabl…
Website
http://www.nap.edu/catalog.php?record_id=11903
Website Notes
Read online or download as PDF.
Author
Olsen, LeighAnne;
Aisner, Dara;
McGinnis, J. Michael (Eds).
Place of Publication
Washington, DC
Publisher
National Academies Press
Publication Date
2007
Physical Description
374 pages, 2 MB PDF file.
Subject
Health Care Delivery Systems
Evidence-Based Medicine
Abstract
This book considers how health care is structured to develop and to apply evidence--from health profession training and infrastructure development to advances in research methodology, patient engagement, payment schemes, and measurement--and highlights opportunities for the creation of a sustainable learning health care system that gets the right care to people when they need it and then captures the results for improvement. This book will be of primary interest to hospital and insurance industry administrators, health care providers, those who train and educate health workers, researchers, and policymakers.
ISBN
978-0-309-10300-8
Language
English
Material Type
Online
Websites
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Moral Distress in the Health Professions

https://cwslc.andornot.com/en/permalink/catalog124765
Philadelphia, USA: Springer , 2021.
Material Type
Book
Call Number
REF IC 100 ULR 2018
Availability
1 copy, 1 available
This is the first book on the market or within academia dedicated solely to moral distress among health professionals. It aims to bring conceptual clarity about moral distress and distinguish it from related concepts. Explicit attention is given to the voices and experiences of health care professi…
  1 image     1 document  
Editor
Ulrich, Connie M
Grady, Christine
Place of Publication
Philadelphia, USA
Publisher
Springer
Publication Date
2021
Physical Description
Paperback: p 171.
Subject
Medical Ethics
Physicians
UBC MD Undergrad
Bioethics
Abstract
This is the first book on the market or within academia dedicated solely to moral distress among health professionals. It aims to bring conceptual clarity about moral distress and distinguish it from related concepts. Explicit attention is given to the voices and experiences of health care professionals from multiple disciplines and many parts of the world. Contributors explain the evolution of the concept of moral distress, sources of moral distress including those that arise at the unit/team and organization/system level, and possible solutions to address moral distress at every level. A liberal use of case studies will make the phenomenon palpable to readers.
This volume provides information not only for academia and educational initiatives, but also for practitioners and the research community, and will serve as a professional resource for courses in health professional schools, bioethics, and business, as well as in the hospital wards, intensive care units, long-term care facilities, hospice, and ambulatory practice sites in which moral distress originates.
ISBN
978-3319-646251
Language
English
Material Type
Book
Call Number
REF IC 100 ULR 2018

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Developments in Neuroethics & Bioethics|Volume 6: Neuroethics & Neurodevelopment

https://cwslc.andornot.com/en/permalink/catalog123781
Campbridge, MA: Elsevier | Academic Press , 2023.
Material Type
Book
Call Number
REF IC 100 GIB 2023
Availability
1 copy, 1 available
This volume focuses on topics at the intersection between neuroethics and neurodevelopment, and brings together the perspectives of experts in both clinical assessment and intervention, and researchers in child psychology, neurosciences, medicine, health policy, law, and social work. The goal is to…
  1 image     1 document  
Editor
Gibbard, W. Ben
Illes, Judy
Place of Publication
Campbridge, MA
Publisher
Elsevier
Academic Press
Publication Date
2023
Physical Description
275pp
Subject
Medical Ethics
Physicians
UBC MD Undergrad
Bioethics
Neuroethics
Abstract
This volume focuses on topics at the intersection between neuroethics and neurodevelopment, and brings together the perspectives of experts in both clinical assessment and intervention, and researchers in child psychology, neurosciences, medicine, health policy, law, and social work. The goal is to review emerging issues related to the ethical ramifications of how variation in human neurodevelopment is described, and the effects of these descriptions on those with lived experience, clinical and intervention services, and health and social policy. Related topics are also explored including the effect of the Covid-19 pandemic, the ethics of invasive neurotechnology interventions, biomarkers, machine learning, precision medicine.
ISBN
978-0323993920
Language
English
Material Type
Book
Call Number
REF IC 100 GIB 2023

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Documents

Neuroethics and Neurodevelopment Volume 6.jpg

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Nature medicine

https://cwslc.andornot.com/en/permalink/catalog119779
Website
PHSA Users:
http://search.ebscohost.com/login.aspx?direct=true&db=edspub&AN=edp50997&site=pfi-live
UBC Users:
http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=AC_T_M&C=Nature+medicine
Alternate Title
Nat. Med.
Place of Publication
New York, NY
Publisher
Nature Publishing Group
Publication Date
1995 - Present.
ISSN
1078-8956
Language
English
Material Type
Serial
Frequency
Monthly
Holdings
CFRI/Study & Learning Commons - Print: v.1:1-v.11:7,10,12 (1995-2005); v.12:10 (2006); v.13:3 (2007); v.14:11+suppls. (2008).
Missing: v.1:2,5 (1995); v.4:1,2,6,8-12 (1998); v.5:1-6 (1999); v.6:8 (2000); v.11:8,9,11 (2005); v.12:1-11 (2006); v.13:1-2 (2007).
Online: 1995 to present.
Websites
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New England journal of medicine

https://cwslc.andornot.com/en/permalink/catalog119831
Website
PHSA Users:
http://search.ebscohost.com/login.aspx?direct=true&db=edspub&AN=edp51617&site=pfi-live
UBC Users:
http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=I_M&C=0028-4793
Alternate Title
NEJM
Place of Publication
[Boston, MA]
Publisher
Massachusetts Medical Society
Publication Date
1990 - Present.
ISSN
0028-4793
Language
English
Material Type
Serial
Frequency
Weekly
Holdings
CFRI/Study & Learning Commons - Print: v.330:20-v.365:17 (1994-2011).
Missing: v.331:10,12,14,15,19-21 (1994); v.332:20 (1995); v.334:13 (1996); v.337:14 (1997); v.338:2,4,12,22 (1998); v.341:16 (1999); v.342:all (2000); v.343:3,4,6-13,15-17,19,21-22,24-26 (2000); v.344:19-21,23,26; v.345:4,5,7-9,11-13,16,17,20-23,26 (2001); v.346:6-9,14,15,18-20,26 (2002); v.349:5-8,11,12,17,18,24 (2003); v.350:21 (2004); v.353:6,8-13,20 (2005); v.354:7,10,16; v.355:15,18,23 (2006); v.356:2,3,20; v.357:23 (2007); v.358:22,23; v.359:16,18 (2008); v.360:23; v.361:1,9-12 (2009); v.362:4; v.363:21 (2010).
Online: 1990 to present.
Websites
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Medicines by design

https://cwslc.andornot.com/en/permalink/catalog113792
National Institutes of Health. [Bethesda, MD]: US Department of Health and Human Services , 2006.
Website
https://publications.nigms.nih.gov/medbydesign/index.html
Material Type
Online
Medicines By Design aims to explain how scientists unravel the many different ways medicines work in the body and how this information guides the hunt for drugs of the future. Pharmacology is a broad discipline encompassing every aspect of the study of drugs, including their discovery and developme…
Website
https://publications.nigms.nih.gov/medbydesign/index.html
Corporate Author
National Institutes of Health
Place of Publication
[Bethesda, MD]
Publisher
US Department of Health and Human Services
Publication Date
2006
Physical Description
PDF file, 60 p.
Subject
Medication
Pharmacology
Abstract
Medicines By Design aims to explain how scientists unravel the many different ways medicines work in the body and how this information guides the hunt for drugs of the future. Pharmacology is a broad discipline encompassing every aspect of the study of drugs, including their discovery and development and the testing of their action in the body.
Language
English
Material Type
Online
Websites
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International classification of functioning, disability and health: Children and youth version: ICF-CY

https://cwslc.andornot.com/en/permalink/catalog113169
World Health Organization. Geneva, Switzerland: World Health Organization , 2012.
Website
www.who.int/classifications/icf/en/
Material Type
Online
Website
www.who.int/classifications/icf/en/
Website Notes
Merged into ICF
Corporate Author
World Health Organization
Place of Publication
Geneva, Switzerland
Publisher
World Health Organization
Publication Date
2012
Subject
Medical Dictionaries. Medical Thesauri. Medical Terminology
Anatomy
Physiology
ISBN
9789241547321
Language
English
Material Type
Online
Websites
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Clinical Genetics: An International Journal of Genetics, Molecular and Personalized Medicine

https://cwslc.andornot.com/en/permalink/catalog114754
Website
PHSA Users:
http://search.ebscohost.com/login.aspx?direct=true&db=edspub&AN=edp18084&site=pfi-live
UBC Users:
http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=AC_T_B&C=clinical+genetics
Place of Publication
Malden, Ma.
Publisher
John Wiley & Sons, Inc.
Publication Date
1970 - Present.
ISSN
0009-9163
Language
English
Material Type
Serial
Frequency
Monthly
Holdings
CFRI/Study & Learning Commons - Print: v.45:6-v.57:4+special issue (1994-2000); v.61:1 (2002); v.69:3-v.76:3 (2006-2009).
Missing: v.51:3, v.52:4 (1997); v.53:2 (1998); v.55:4, v.56:1,3 (1999); v.57:1-3, v.58:1-6 (2000); v.59:1-6, v.60:1-6 (2001); v.61:2-6, v.62:1-6 (2002); 2003-2005; v.69:1-2 (2006); v.73:3-5 (2008); v.75:1,3,4, v.76:2,4-6 (2009).
Online: 1970 to present.
Websites
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Canadian journal of rural medicine: The official journal of the Society of Rural Physicians of Canada

https://cwslc.andornot.com/en/permalink/catalog114596
Website
PHSA Users:
http://web.a.ebscohost.com/pfi/detail/detail?vid=15&sid=80dd29ce-f1c9-480f-93d5-346abac169f7%40sessionmgr4009&hid=4106&bdata=JnNpdGU9cGZpLWxpdmU%3d#AN=edp15358&db=edspub
UBC Users:
http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=AC_T_B&C=Canadian+journal+of+rural+medicine
Alternate Title
Canadian journal of rural medicine : the official journal of the Society of Rural Physicians of Canada = Journal canadien de la médecine rurale : le journal officiel de la Société de médecine rurale du Canada.
Corporate Author
Society of Rural Physicians of Canada
Place of Publication
[Ottawa, ON]
Publisher
Canadian Medical Association
Publication Date
1996 - Present
Notes
Articles in English; some are also in French.
ISSN
1203-7796
Language
English, French
Material Type
Serial
Frequency
Quarterly
Holdings
CFRI/Study & Learning Commons - Print:v.10:1-v.15:4 (2005-2010); v.16:3 (2011); v.17:1-2 (2012).
Missing: v.8:2-4 (2003); v.9:1-4 (2004); v.11:4 (2006); v.12:4 (2007); v.13:2 (2008).
Online: 1996 to present.
Websites
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Profiling the vaginal microbiome in HIV-positive women

https://cwslc.andornot.com/en/permalink/catalog113942
Mahal, Daljeet Singh. [Vancouver, BC?]: University of British Columbia , 2013.
Website
http://hdl.handle.net/2429/44267
Material Type
Thesis
Call Number
Thesis Shelf
Disruptions or imbalances of the vaginal microbiome can lead to negative reproductive health consequences for women, including an increased risk of sexually transmitted infections, pelvic inflammatory disease, and preterm birth. HIV-positive women may be particularly vulnerable to microbiome disrup…
Website
http://hdl.handle.net/2429/44267
Author
Mahal, Daljeet Singh
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2013
Subject
Faculty of Medicine
Theses
Abstract
Disruptions or imbalances of the vaginal microbiome can lead to negative reproductive health consequences for women, including an increased risk of sexually transmitted infections, pelvic inflammatory disease, and preterm birth. HIV-positive women may be particularly vulnerable to microbiome disruptions due to the immune dysfunction intrinsic to this disease. The objective of this study was to explore the vaginal microbiome in HIV-positive reproductive-aged women utilizing cpn60 metagenomic profiling and to correlate vaginal bacterial profiles with demographic/clinical variables.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Cardiovascular, metabolic, endocrine and behavioral aspects of development in postnatal lambs in relation to age, sex, lamb number and acute fluoxetine administration

https://cwslc.andornot.com/en/permalink/catalog113943
Nguyen, Tuan-Anh Thi. [Vancouver, BC?]: University of British Columbia , 2013.
Website
http://hdl.handle.net/2429/44653
Material Type
Thesis
Call Number
Thesis Shelf
Human newborns exposed in utero to maternally administered SSRIs such as fluoxetine (FX) have an increased risk of adverse pregnancy outcomes including poor neonatal adaptation. This comprises respiratory difficulty, jitteriness, cyanosis when feeding and persists for several days after birth. Seve…
Website
http://hdl.handle.net/2429/44653
Author
Nguyen, Tuan-Anh Thi
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2013
Subject
Faculty of Medicine
Theses
Abstract
Human newborns exposed in utero to maternally administered SSRIs such as fluoxetine (FX) have an increased risk of adverse pregnancy outcomes including poor neonatal adaptation. This comprises respiratory difficulty, jitteriness, cyanosis when feeding and persists for several days after birth. Several potential mechanisms underlying these symptoms have been proposed: 1) acute toxicity to the drugs (i.e. serotonin syndrome), 2) withdrawal syndrome due to the sudden discontinuation of maternal-fetal placental drug transfer at birth or 3) an SSRIs-elicited alteration in fetal brain development. However, the actual mechanism has not been elucidated.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Role of receptor tyrosine kinase regulator Sprouty in ovarian cancer cells

https://cwslc.andornot.com/en/permalink/catalog113944
So, Wai Kin. [Vancouver, BC?]: University of British Columbia , 2012.
Website
http://hdl.handle.net/2429/42242
Material Type
Thesis
Call Number
Thesis Shelf
Aberrant epidermal growth factor receptor (EGFR) activity contributes to the development of epithelial ovarian cancer (EOC), a common and lethal female malignancy. Elucidating the regulation of EGFR function will improve treatments for EOC and the survival of patients. This study aims to elucidate …
Website
http://hdl.handle.net/2429/42242
Author
So, Wai Kin
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2012
Subject
Faculty of Medicine
Theses
Abstract
Aberrant epidermal growth factor receptor (EGFR) activity contributes to the development of epithelial ovarian cancer (EOC), a common and lethal female malignancy. Elucidating the regulation of EGFR function will improve treatments for EOC and the survival of patients. This study aims to elucidate the role of Sprouty (SPRY) proteins, which are EGFR regulators, in EOC.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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X-chromosome inactivation and FMR1 CGG repeat and AGG interspersion number in female newborns conceived by assisted reproductive technologies (ARTs)

https://cwslc.andornot.com/en/permalink/catalog113945
Wu, Elizabeth Xianshi. [Vancouver, BC?]: University of British Columbia , 2012.
Website
http://hdl.handle.net/2429/42609
Material Type
Thesis
Call Number
Thesis Shelf
Pregnancies derived from in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with increased rates of chromosome abnormalities, congenital malformations, low birth weight, pre-term births, multiple gestations, and imprinting disorders. Assisted reproductive techno…
Website
http://hdl.handle.net/2429/42609
Author
Wu, Elizabeth Xianshi
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2012
Subject
Faculty of Medicine
Theses
Abstract
Pregnancies derived from in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with increased rates of chromosome abnormalities, congenital malformations, low birth weight, pre-term births, multiple gestations, and imprinting disorders. Assisted reproductive technologies (ARTs) enable sub-fertile individuals to circumvent the natural selective pressures involved in human reproduction. The risks of ARTs may be due to the underlying causes of subfertility in these individuals or to the artificial processes used to achieve pregnancy. X-chromosome inactivation (XCI) may be at risk to perturbations in ARTs as it is thought to occur during the blastocyst stage when in vitro culturing would be taking place. We examined the XCI status in females conceived by ICSI (n=70), IVF (n=68), and naturally (NC, n=42).
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Noninvasive assessment of embryo quality in human in vitro fertilization : metabolomic profiling of embryo culture media with Raman spectroscopy

https://cwslc.andornot.com/en/permalink/catalog113946
Asghari Roodsari, Alaleh. [Vancouver, BC?]: University of British Columbia , 2012.
Website
http://hdl.handle.net/2429/43273
Material Type
Thesis
Call Number
Thesis Shelf
Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. …
Website
http://hdl.handle.net/2429/43273
Author
Asghari Roodsari, Alaleh
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2012
Subject
Faculty of Medicine
Theses
Abstract
Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. We therefore undertook the following study to further assess the usefulness of metabolomic profiling ?spent? embryo culture medium using Raman spectroscopy. Methods: Patients undergoing IVF+/-ICSI treatment from the UBC Centre for Reproductive Health were recruited for study.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Investigation of methylation and gene expression in placenta of pregnancies conceived by assisted reproductive technology (ART)

https://cwslc.andornot.com/en/permalink/catalog113947
Sakian, Sina. [Vancouver, BC?]: University of British Columbia , 2011.
Website
http://hdl.handle.net/2429/31191
Material Type
Thesis
Call Number
Thesis Shelf
With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures wi…
Website
http://hdl.handle.net/2429/31191
Author
Sakian, Sina
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2011
Subject
Faculty of Medicine
Theses
Abstract
With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures with increased incidence of low birth weight (LBW), chromosomal abnormalities, birth defects and imprinting disorders. No study has proposed a single defined cause for any of these defects in ART infants, however it is believed that they may be due to both the invasiveness of ART and to genetic defects that are at the root of the infertility in the parents. In this study, changes in the methylation of the H19 and IGF2 imprinting control region 1 (ICR1) were investigated for both ART (n=92) and naturally conceived controls (n=19) using pyrosequencing.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Regulation of androgen action by sex hormone-binding globulin

https://cwslc.andornot.com/en/permalink/catalog113948
Hong, Eui-ju. [Vancouver, BC?]: University of British Columbia , 2011.
Website
http://hdl.handle.net/2429/35861
Material Type
Thesis
Call Number
Thesis Shelf
Sex hormone-binding globulin (SHBG) binds androgens and estrogens with high affinity, and regulates the distribution of these sex steroids in the blood and other biological fluids. Liver is the primary site of SHBG production, but the human SHBG transcription unit responsible for this is also expre…
Website
http://hdl.handle.net/2429/35861
Author
Hong, Eui-ju
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2011
Subject
Faculty of Medicine
Theses
Abstract
Sex hormone-binding globulin (SHBG) binds androgens and estrogens with high affinity, and regulates the distribution of these sex steroids in the blood and other biological fluids. Liver is the primary site of SHBG production, but the human SHBG transcription unit responsible for this is also expressed in proximal convoluted tubule (PCT) epithelial cells in a transgenic mouse model. Unlike hepatocytes which actively secrete SHBG and retain little immunoreactive SHBG within their cytoplasm, an incompletely glycosylated SHBG isoform has been found to accumulate inside PCT cells. These cells are androgen target cells, and the presence of SHBG within them accentuates androgen-dependent regulation of gene expression mediated by the androgen receptor (AR).
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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20 records – page 1 of 1.