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9 records – page 1 of 1.

Characterization of the human gonadotropin-releasing hormone receptor gene at the molecular level

https://cwslc.andornot.com/en/permalink/catalog113982
Fan, Nancy C. [Vancouver, BC?]: University of British Columbia , 1995.
Website
http://hdl.handle.net/2429/7255
Material Type
Thesis
Call Number
Thesis Shelf
The gonadotropin - releasing hormone (GnRH) receptor is a plasma membrane associated receptor and a member of the GTP - binding protein coupled receptor family. The interaction of the ligand, GnRH, and the GnRH receptor is a critical event in the endocrine control of reproduction. This coupling sti…
More Information is Available
  1 website  
Website
http://hdl.handle.net/2429/7255
Author
Fan, Nancy C.
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1995
Subject
Faculty of Medicine
Theses
Abstract
The gonadotropin - releasing hormone (GnRH) receptor is a plasma membrane associated receptor and a member of the GTP - binding protein coupled receptor family. The interaction of the ligand, GnRH, and the GnRH receptor is a critical event in the endocrine control of reproduction. This coupling stimulates the synthesis and release of both luteinizing hormone and follicle stimulating hormone from the anterior pituitary. In addition, GnRH - GnRH receptor binding acts locally to regulate human chorionic gonadotropin secretion in the placenta and steroidogenesis in the ovary. The objective of this thesis was to isolate and characterize the gene for the GnRH receptor in human.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
http://hdl.handle.net/2429/7255
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Human molecular genetics

https://cwslc.andornot.com/en/permalink/catalog119692
Oxford, England: Oxford University Press , 1992 - Present.
Website
PHSA Users:
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http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=AC_T_M&C=human+molecular+genetics
Material Type
Serial
More Information is Available
  4 websites  
Website
PHSA Users:
http://search.ebscohost.com/login.aspx?direct=true&db=edspub&AN=edp33596&site=pfi-live
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Place of Publication
Oxford, England
Publisher
Oxford University Press
Publication Date
1992 - Present
ISSN
0964-6906
Language
English
Material Type
Serial
Frequency
Bimonthly
Holdings
CFRI/Study & Learning Commons - Print: v.3:1-v.8:13 (1994-1999); v.9:15-16 (2000); v.10:1-16,19,20,22-25 (2001); v.11:17,20 (2002); v.12:13 (2003).
Missing: v.4:8 (1995); v.5:8 (1996); v.6:8,10 (1997).
Online: 1992 to present.
Websites
PHSA Users:
http://search.ebscohost.com/login.aspx?direct=true&db=edspub&AN=edp33596&site=pfi-live
UBC Users:
http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=AC_T_M&C=human+molecular+genetics
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Localization and regulation of mRNA transcripts encoding activin receptors in human placental trophoblast cells

https://cwslc.andornot.com/en/permalink/catalog113978
Chen, Victor. [Vancouver, BC?]: University of British Columbia , 1997.
Website
http://hdl.handle.net/2429/6315
Material Type
Thesis
Call Number
Thesis Shelf
There is increasing evidence to suggest that activin can function as an autocrine/paracrine regulator in various tissues, including the reproductive system. At the cellular level, activin acts via a family of activin receptor (ActR) subtypes which includes two type I (ActRI and ActRLB) and two type…
More Information is Available
  1 website  
Website
http://hdl.handle.net/2429/6315
Author
Chen, Victor
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1997
Subject
Faculty of Medicine
Theses
Abstract
There is increasing evidence to suggest that activin can function as an autocrine/paracrine regulator in various tissues, including the reproductive system. At the cellular level, activin acts via a family of activin receptor (ActR) subtypes which includes two type I (ActRI and ActRLB) and two type II (II and ILB) receptors. The role of activin in the human placenta is not clearly understood. In this study, the detection of inlubin/activin subunit and ActRI mRNA were examined in first trimester cytotrophoblasts, term cytotrophoblasts, extravillous trophoblast (EVT) cells, immortalized extravillous trophoblast (LEVT) cells, JEG-3 cells, decidual tissue, and decidual cells.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
http://hdl.handle.net/2429/6315
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The molecular biology of calbindin-D9k

https://cwslc.andornot.com/en/permalink/catalog113987
Jeung, Eui-Bae. [Vancouver, BC?]: University of British Columbia , 1993.
Website
http://hdl.handle.net/2429/1766
Material Type
Thesis
Call Number
Thesis Shelf
Calbindin-D9k is a cytosolic calcium binding protein expressed in the mammalian intestine, placenta, and uterus. The protein is probably involved in calcium transport across the intestinal and placental epithelia. The objective of this thesis was to study the structure of the human and porcine calb…
More Information is Available
  1 website  
Website
http://hdl.handle.net/2429/1766
Author
Jeung, Eui-Bae
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1993
Subject
Faculty of Medicine
Theses
Abstract
Calbindin-D9k is a cytosolic calcium binding protein expressed in the mammalian intestine, placenta, and uterus. The protein is probably involved in calcium transport across the intestinal and placental epithelia. The objective of this thesis was to study the structure of the human and porcine calbindin-D9k at the cDNA and genomic level. The cDNAs for the bovine, murine, and ratcalbindin-D9k as well as the gene for rat calbindin-D9k had been cloned previously.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
http://hdl.handle.net/2429/1766
Show Less

Nature cell biology

https://cwslc.andornot.com/en/permalink/catalog119774
London, UK.: Nature Publishing Group , 1999 - Present.
Website
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UBC Users:
http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=AC_T_M&C=Nature+cell+biology
Material Type
Serial
More Information is Available
  4 websites  
Website
PHSA Users:
http://search.ebscohost.com/login.aspx?direct=true&db=edspub&AN=edp78330&site=pfi-live
UBC Users:
http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=AC_T_M&C=Nature+cell+biology
Alternate Title
Nat. Cell Biol.
Place of Publication
London, UK.
Publisher
Nature Publishing Group
Publication Date
1999 - Present.
ISSN
1465-7392
Language
English
Material Type
Serial
Frequency
Monthly
Holdings
CFRI/Study & Learning Commons - Print: v.4:2-v.16:6 (2002-2014).
Missing: v.4:1 (2002); v.11:8 (2009).
Online: 1999 to present.
Websites
PHSA Users:
http://search.ebscohost.com/login.aspx?direct=true&db=edspub&AN=edp78330&site=pfi-live
UBC Users:
http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=AC_T_M&C=Nature+cell+biology
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Prostaglandin F[sub 2a]-mediated luteolytic and luteotrophic effects on the human granulosa-luteal cell

https://cwslc.andornot.com/en/permalink/catalog113976
Vaananen, Jeffrey Eric. [Vancouver, BC?]: University of British Columbia , 1997.
Website
http://hdl.handle.net/2429/6811
Material Type
Thesis
Call Number
Thesis Shelf
These studies examined the effects of prostaglandin-F[sub 2a] (PGF[sub 2a]) on progesterone and 178-estradiol (estradiol) production, as well as DNA and PGF[sub 2a]-receptor (PGF[sub 2a]-R) mRNA levels, in the human granulosa-luteal cell (GLC). Additionally, the interactions of PGF[sub 2a] with hum…
More Information is Available
  1 website  
Website
http://hdl.handle.net/2429/6811
Author
Vaananen, Jeffrey Eric
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1997
Subject
Faculty of Medicine
Theses
Abstract
These studies examined the effects of prostaglandin-F[sub 2a] (PGF[sub 2a]) on progesterone and 178-estradiol (estradiol) production, as well as DNA and PGF[sub 2a]-receptor (PGF[sub 2a]-R) mRNA levels, in the human granulosa-luteal cell (GLC). Additionally, the interactions of PGF[sub 2a] with human chorionic gonadotrophin (hCG), gonadotrophin-releasing hormone (GnRH) and prostaglandin E₂ (PGE₂) were examined, with respect to progesterone and estradiol production.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
http://hdl.handle.net/2429/6811
Show Less

Regulation of cytochrome P450 and P450 mRNA in human granulosa-luteal cells

https://cwslc.andornot.com/en/permalink/catalog113984
Ge, Hong. [Vancouver, BC?]: University of British Columbia , 1994.
Website
http://hdl.handle.net/2429/3482
Material Type
Thesis
Call Number
Thesis Shelf
This thesis investigated the expression and regulation of cytochrome P450s, aromatase (P450arom) and cholesterol side chain cleavage (P450scc) enzyme mRNAs in human granulosa-luteal cells using reverse transcription-polymerase chain reaction (RT-PCR). The two enzymes are instrumental in steroid hor…
More Information is Available
  1 website  
Website
http://hdl.handle.net/2429/3482
Author
Ge, Hong
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1994
Subject
Faculty of Medicine
Theses
Abstract
This thesis investigated the expression and regulation of cytochrome P450s, aromatase (P450arom) and cholesterol side chain cleavage (P450scc) enzyme mRNAs in human granulosa-luteal cells using reverse transcription-polymerase chain reaction (RT-PCR). The two enzymes are instrumental in steroid hormone biosynthesis.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
http://hdl.handle.net/2429/3482
Show Less

Single cell studies of calcium as second messenger in human granulosa-lutein and embryonic kidney 293 cells

https://cwslc.andornot.com/en/permalink/catalog113979
Lee, Pearly S.N. [Vancouver, BC?]: University of British Columbia , 1999.
Website
http://hdl.handle.net/2429/10789
Material Type
Thesis
Call Number
Thesis Shelf
It is well established that LH action is mediated primarily by adenylate cyclase/cAMP. Conversely, the role of inositol phosphate/calcium in LH signalling has only recently been investigated. We examined the effects of gonadotrophins on intracellular calcium mobilisation in HEK293 cells transiently…
More Information is Available
  1 website  
Website
http://hdl.handle.net/2429/10789
Author
Lee, Pearly S.N.
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1999
Subject
Faculty of Medicine
Theses
Abstract
It is well established that LH action is mediated primarily by adenylate cyclase/cAMP. Conversely, the role of inositol phosphate/calcium in LH signalling has only recently been investigated. We examined the effects of gonadotrophins on intracellular calcium mobilisation in HEK293 cells transiently transfected with human wild type or chimeric gonadotrophs receptors (n=3400). Intracellular free calcium concentration was measured using fura-2 microspectrofluorimetric techniques. Human LH (2-4 μg/ml) arid CG (10 IU/ml) consistently evoked oscillatory calcium signals in HEK293 cells transfected with hLHr, whereas hFSH (2-4 μg/ml) failed to elicit any calcium responses.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
http://hdl.handle.net/2429/10789
Show Less

Trends in cell biology

https://cwslc.andornot.com/en/permalink/catalog119853
Cambridge, Ma.: Elsevier Inc. , 1990 - Present.
Website
PHSA Users:
Not available online.
UBC Users:
http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=I_M&C=0962-8924
Material Type
Serial
More Information is Available
  4 websites  
Website
PHSA Users:
Not available online.
UBC Users:
http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=I_M&C=0962-8924
Place of Publication
Cambridge, Ma.
Publisher
Elsevier Inc.
Publication Date
1990 - Present.
ISSN
0962-8924
Language
English
Material Type
Serial
Frequency
Monthly
Holdings
CFRI/Study & Learning Commons - Print: v.4:10-v.8:12 (1994-1998); v.9:1,6 (1999); v.11:12-v.24:2 (2001-2014).
Missing: v.4:11 (1994); v.5:1 (1995); v.8:3 (1998); v.9:2-5,7-12 (1999); v.10:all (2000); v.13:12 (2003); v.14:1-2 (2004).
Online: 1990 to present.
Websites
PHSA Users:
Not available online.
UBC Users:
http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=I_M&C=0962-8924
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9 records – page 1 of 1.