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3 records – page 1 of 1.

Action of luteinizing hormone-releasing hormone in rat ovarian cells : hormone production and signal transduction

https://cwslc.andornot.com/en/permalink/catalog113996
Wang, Jian. [Vancouver, BC?]: University of British Columbia , 1989.
Website
http://hdl.handle.net/2429/29313
Material Type
Thesis
Call Number
Thesis Shelf
The present study was conducted to investigate the hypothesis that membrane phosphoinositide breakdown may participate in the actions of luteinizing hormone-releasing hormone (LHRH) on hormone production in the rat ovary. In granulosa cells prelabeled with [³H]-arachidonic acid or [³H]-inositol, tr…
Website
http://hdl.handle.net/2429/29313
Author
Wang, Jian
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1989
Subject
Faculty of Medicine
Theses
Abstract
The present study was conducted to investigate the hypothesis that membrane phosphoinositide breakdown may participate in the actions of luteinizing hormone-releasing hormone (LHRH) on hormone production in the rat ovary. In granulosa cells prelabeled with [³H]-arachidonic acid or [³H]-inositol, treatment with LHRH increased the accumulation of radiolabeled inositol lipids, diacylglycerol and free arachidonic acid, but luteinizing hormone (LH) or cholera toxin did not exert the same effect. Activation of protein kinase C by the phorbol ester, 12-0-tetradecanoyl phorbol-13-acetate (TPA) had a stimulatory action on membrane phosphoinositide breakdown.
Language
English
Material Type
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Clinical and endocrine responses to ovarian hyperstimulation in flare and and luteal gonadotropin-releasing hormone agonist (GnRHa) protocols

https://cwslc.andornot.com/en/permalink/catalog113958
Nguyen, Tuan-Anh T. [Vancouver, BC?]: University of British Columbia , 2008.
Website
http://hdl.handle.net/2429/1395
Material Type
Thesis
Call Number
Thesis Shelf
Due to the ?flare effect? associated with the flare protocol, variation in the degree of follicular maturation during stimulation may result in differences in follicle response as compared to the luteal protocol which is based on maximal pituitary suppression and synchronization of follicular matur…
Website
http://hdl.handle.net/2429/1395
Author
Nguyen, Tuan-Anh T
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2008
Subject
Faculty of Medicine
Theses
Abstract
Due to the ?flare effect? associated with the flare protocol, variation in the degree of follicular maturation during stimulation may result in differences in follicle response as compared to the luteal protocol which is based on maximal pituitary suppression and synchronization of follicular maturation. In this study, besides other methods, Anti-Mullerian Hormone (AMH), a novel marker for ovarian reserve, was used as a tool to evaluate the ovarian responsiveness to stimulation.
Language
English
Material Type
Thesis
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Regulation of androgen action by sex hormone-binding globulin

https://cwslc.andornot.com/en/permalink/catalog113948
Hong, Eui-ju. [Vancouver, BC?]: University of British Columbia , 2011.
Website
http://hdl.handle.net/2429/35861
Material Type
Thesis
Call Number
Thesis Shelf
Sex hormone-binding globulin (SHBG) binds androgens and estrogens with high affinity, and regulates the distribution of these sex steroids in the blood and other biological fluids. Liver is the primary site of SHBG production, but the human SHBG transcription unit responsible for this is also expre…
Website
http://hdl.handle.net/2429/35861
Author
Hong, Eui-ju
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2011
Subject
Faculty of Medicine
Theses
Abstract
Sex hormone-binding globulin (SHBG) binds androgens and estrogens with high affinity, and regulates the distribution of these sex steroids in the blood and other biological fluids. Liver is the primary site of SHBG production, but the human SHBG transcription unit responsible for this is also expressed in proximal convoluted tubule (PCT) epithelial cells in a transgenic mouse model. Unlike hepatocytes which actively secrete SHBG and retain little immunoreactive SHBG within their cytoplasm, an incompletely glycosylated SHBG isoform has been found to accumulate inside PCT cells. These cells are androgen target cells, and the presence of SHBG within them accentuates androgen-dependent regulation of gene expression mediated by the androgen receptor (AR).
Language
English
Material Type
Thesis
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