Website

http://hdl.handle.net/2429/44653

Author

Nguyen, Tuan-Anh Thi

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2013

Subject

Faculty of Medicine

Theses

Abstract

Human newborns exposed in utero to maternally administered SSRIs such as fluoxetine (FX) have an increased risk of adverse pregnancy outcomes including poor neonatal adaptation. This comprises respiratory difficulty, jitteriness, cyanosis when feeding and persists for several days after birth. Several potential mechanisms underlying these symptoms have been proposed: 1) acute toxicity to the drugs (i.e. serotonin syndrome), 2) withdrawal syndrome due to the sudden discontinuation of maternal-fetal placental drug transfer at birth or 3) an SSRIs-elicited alteration in fetal brain development. However, the actual mechanism has not been elucidated.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/6844

Author

Menzies, Jennifer Marie

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2009

Subject

Faculty of Medicine

Theses

Abstract

This research responded to the need to define evidence-based criteria of maternal risk by developing a model - the Pre-eclampsia Integrated Estimate of RiSk (or PIERS) model ? that predicts a combined adverse maternal outcome (mortality and/or significant morbidities) within 48 hour of, and up to seven days after, admission with pre-eclampsia (study eligibility)

Language

English

Material Type

Thesis

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Thesis Shelf

Copies

Website

http://hdl.handle.net/2429/42609

Author

Wu, Elizabeth Xianshi

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2012

Subject

Faculty of Medicine

Theses

Abstract

Pregnancies derived from in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with increased rates of chromosome abnormalities, congenital malformations, low birth weight, pre-term births, multiple gestations, and imprinting disorders. Assisted reproductive technologies (ARTs) enable sub-fertile individuals to circumvent the natural selective pressures involved in human reproduction. The risks of ARTs may be due to the underlying causes of subfertility in these individuals or to the artificial processes used to achieve pregnancy. X-chromosome inactivation (XCI) may be at risk to perturbations in ARTs as it is thought to occur during the blastocyst stage when in vitro culturing would be taking place. We examined the XCI status in females conceived by ICSI (n=70), IVF (n=68), and naturally (NC, n=42).

Language

English

Material Type

Thesis

Call Number

Thesis Shelf