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6 records – page 1 of 1.

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Clinical and endocrine responses to ovarian hyperstimulation in flare and and luteal gonadotropin-releasing hormone agonist (GnRHa) protocols

https://cwslc.andornot.com/en/permalink/catalog113958

Nguyen, Tuan-Anh T. [Vancouver, BC?]: University of British Columbia , 2008.

Website: http://hdl.handle.net/2429/1395

Material Type: Thesis

Call Number: Thesis Shelf

Due to the ?flare effect? associated with the flare protocol, variation in the degree of follicular maturation during stimulation may result in differences in follicle response as compared to the luteal protocol which is based on maximal pituitary suppression and synchronization of follicular matur…

1 website

Website: http://hdl.handle.net/2429/1395

Author: Nguyen, Tuan-Anh T

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 2008

Subject: Faculty of Medicine; Theses

Abstract: Due to the ?flare effect? associated with the flare protocol, variation in the degree of follicular maturation during stimulation may result in differences in follicle response as compared to the luteal protocol which is based on maximal pituitary suppression and synchronization of follicular maturation. In this study, besides other methods, Anti-Mullerian Hormone (AMH), a novel marker for ovarian reserve, was used as a tool to evaluate the ovarian responsiveness to stimulation.

Language: English

Material Type: Thesis

Call Number: Thesis Shelf

Websites

http://hdl.handle.net/2429/1395

Effects and mechanisms of growth differentiation factor 9 on activin A-regulated inhibin B and progesterone production in human granulosa cells

https://cwslc.andornot.com/en/permalink/catalog113951

Shi, Fengtao. [Vancouver, BC?]: University of British Columbia , 2010.

Website: http://hdl.handle.net/2429/28961

Material Type: Thesis

Call Number: Thesis Shelf

Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regul…

1 website

Website: http://hdl.handle.net/2429/28961

Author: Shi, Fengtao

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 2010

Subject: Faculty of Medicine; Theses

Abstract: Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regulator of ovarian function, but its overall effects, particularly relating to activin A actions, are unknown. We examined the potential crosstalk between activin A and GDF9 in primary cultures of human granulosa-lutein (hGL) cells. Pretreatment of hGL cells with GDF9 for 24 h resulted in an increased expression of activin receptors and Smad2/3, and decreased inhibitory Smad7 activity. These effects were attenuated by BMP type II receptor ectodomain (BMPR2 ECD), a GDF9 antagonist.

Language: English

Material Type: Thesis

Call Number: Thesis Shelf

Websites

http://hdl.handle.net/2429/28961

Fish analysis of chromosomal aneuploidies in spermatozoa from severely infertile men undergoing intracytoplasmic sperm injection (ICSI)

https://cwslc.andornot.com/en/permalink/catalog113969

Gao, Haijun. [Vancouver, BC?]: University of British Columbia , 2004.

Website: http://hdl.handle.net/2429/16195

Material Type: Thesis

Call Number: Thesis Shelf

The association between subsets of male infertility, oligoasthenoteratozoospermia (OAT), obstructive azoospermic (OA), non-obstructive azoospermia (NOA), and increased risk of having chromosomal abnormalities in the sperm has not been investigated. Chromosomal aneuploidy in sperm will be systematic…

1 website

Website: http://hdl.handle.net/2429/16195

Author: Gao, Haijun

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 2004

Subject: Faculty of Medicine; Theses

Abstract: The association between subsets of male infertility, oligoasthenoteratozoospermia (OAT), obstructive azoospermic (OA), non-obstructive azoospermia (NOA), and increased risk of having chromosomal abnormalities in the sperm has not been investigated. Chromosomal aneuploidy in sperm will be systematically investigated by standard methods with large sample sizes required to present significance.

Language: English

Material Type: Thesis

Call Number: Thesis Shelf

Websites

http://hdl.handle.net/2429/16195

Gonadotropins and leptin : the role and molecular mechanism in normal and neoplastic ovarian epithelium cells

https://cwslc.andornot.com/en/permalink/catalog113965

Choi, Jung-Hye. [Vancouver, BC?]: University of British Columbia , 2006.

Website: http://hdl.handle.net/2429/18509

Material Type: Thesis

Call Number: Thesis Shelf

Ovarian cancer is the sixth most common cancer and the fifth leading cause of cancer-related death among women in developed countries. There is increasing evidence suggesting that the hormonal environment of the normal ovarian surface epithelium (OSE) and ovarian epithelial cancer (OEC) cells is as…

1 website

Website: http://hdl.handle.net/2429/18509

Author: Choi, Jung-Hye

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 2006

Subject: Faculty of Medicine; Theses

Abstract: Ovarian cancer is the sixth most common cancer and the fifth leading cause of cancer-related death among women in developed countries. There is increasing evidence suggesting that the hormonal environment of the normal ovarian surface epithelium (OSE) and ovarian epithelial cancer (OEC) cells is associated with the development and progression of ovarian cancer. Exposure to excess gonadotropins and leptin, related to menopause or infertility therapy and obesity, respectively, has been implicated as a risk factor for ovarian cancer.

Language: English

Material Type: Thesis

Call Number: Thesis Shelf

Websites

http://hdl.handle.net/2429/18509

Human gonadotropin-releasing hormone-II regulation in ovarian cancer : mechanisms and potential functional role

https://cwslc.andornot.com/en/permalink/catalog113953

Poon, Song Ling. [Vancouver, BC?]: University of British Columbia , 2010.

Website: http://hdl.handle.net/2429/30021

Material Type: Thesis

Call Number: Thesis Shelf

It is increasingly apparent that GnRH-II acts as an autocrine/paracrine regulator in non-pituitary tissues, in addition to its role in the regulation of gonadotropin synthesis, and is an important player in cancer cell biology. High levels of GnRH-II and GnRHR in malignant ovarian tumors as compare…

1 website

Website: http://hdl.handle.net/2429/30021

Author: Poon, Song Ling

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 2010

Subject: Faculty of Medicine; Theses

Abstract: It is increasingly apparent that GnRH-II acts as an autocrine/paracrine regulator in non-pituitary tissues, in addition to its role in the regulation of gonadotropin synthesis, and is an important player in cancer cell biology. High levels of GnRH-II and GnRHR in malignant ovarian tumors as compared with benign ovarian tissues underlies the importance of understanding GnRH-II function in ovarian cancer. In an attempt to define the regulation of GnRH-II in these tissues, we found that a cyclic-AMP responsive element (CRE) is critical for GnRH-II promoter transcription.

Language: English

Material Type: Thesis

Call Number: Thesis Shelf

Websites

http://hdl.handle.net/2429/30021

Roles of Confined Placental Mosaicism (CPM) and H19/IGF2 imprinting in pregnancies derived from intracytoplasmic sperm injection (ICSI)

https://cwslc.andornot.com/en/permalink/catalog113961

Hatakeyama, Chiho. [Vancouver, BC?]: University of British Columbia , 2007.

Website: http://hdl.handle.net/2429/32719

Material Type: Thesis

Call Number: Thesis Shelf

In contrast to the success of ICSI in treating male infertility, concerns have been raised about the health outcomes of the children conceived through this procedure. Cohort studies have shown that the ICSI population has an increase in low birth weight (LBW), birth defects, chromosomal abnormaliti…

1 website

Website: http://hdl.handle.net/2429/32719

Author: Hatakeyama, Chiho

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 2007

Subject: Faculty of Medicine; Theses

Abstract: In contrast to the success of ICSI in treating male infertility, concerns have been raised about the health outcomes of the children conceived through this procedure. Cohort studies have shown that the ICSI population has an increase in low birth weight (LBW), birth defects, chromosomal abnormalities, and imprinting disorders. However, the underlying causes remain unknown.

Language: English

Material Type: Thesis

Call Number: Thesis Shelf

Websites

http://hdl.handle.net/2429/32719

6 records – page 1 of 1.

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