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Chromosome segregation and meiotic defects in carriers of chromosomal abnormalities

https://cwslc.andornot.com/en/permalink/catalog113956

Kirkpatrick, Gordon. [Vancouver, BC?]: University of British Columbia , 2009.

Website: http://hdl.handle.net/2429/9705

Material Type: Thesis

Call Number: Thesis Shelf

Male carriers of chromosomal abnormalities (CA) are more frequent in the infertile population. These men have higher levels of sperm aneuploidy due to the aberrant segregation of the chromosomes involved in the abnormality. The presence of a CA may also influence the segregation of other chromosome…

1 website

Website: http://hdl.handle.net/2429/9705

Author: Kirkpatrick, Gordon

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 2009

Subject: Faculty of Medicine; Theses

Abstract: Male carriers of chromosomal abnormalities (CA) are more frequent in the infertile population. These men have higher levels of sperm aneuploidy due to the aberrant segregation of the chromosomes involved in the abnormality. The presence of a CA may also influence the segregation of other chromosomes, in a process known as in interchromosomal effect (ICE). The behaviour of the CA during meiosis may account for the infertility observed in this population. We studied chromosome segregation, ICE and meiotic defects in a variety of CA. In carriers of CA, we determined the segregation patterns of chromosomes involved in the abnormality.

Language: English

Material Type: Thesis

Call Number: Thesis Shelf

Websites

http://hdl.handle.net/2429/9705

Meiotic defects in infertile men

https://cwslc.andornot.com/en/permalink/catalog113960

Ferguson, Kyle Akira. [Vancouver, BC?]: University of British Columbia , 2008.

Website: http://hdl.handle.net/2429/1228

Material Type: Thesis

Call Number: Thesis Shelf

While the introduction of intracytoplasmic sperm injection (ICSI) has revolutionized the treatment of male infertility, concerns have been raised regarding the risk of chromosomal abnormalities in pregnancies derived from ICSI. Studies on sperm from infertile men have suggested that this population…

1 website

Website: http://hdl.handle.net/2429/1228

Author: Ferguson, Kyle Akira

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 2008

Subject: Faculty of Medicine; Theses

Abstract: While the introduction of intracytoplasmic sperm injection (ICSI) has revolutionized the treatment of male infertility, concerns have been raised regarding the risk of chromosomal abnormalities in pregnancies derived from ICSI. Studies on sperm from infertile men have suggested that this population may produce higher rates of aneuploid sperm. Thus, we hypothesized that defects in early meiotic events may contribute to both male infertility and the production of aneuploid sperm.

Language: English

Material Type: Thesis

Call Number: Thesis Shelf

Websites

http://hdl.handle.net/2429/1228