name:"Kirkpatrick, Gordon" found 1 record

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Chromosome segregation and meiotic defects in carriers of chromosomal abnormalities

https://cwslc.andornot.com/en/permalink/catalog113956

Kirkpatrick, Gordon. [Vancouver, BC?]: University of British Columbia , 2009.

Website: http://hdl.handle.net/2429/9705

Material Type: Thesis

Call Number: Thesis Shelf

Male carriers of chromosomal abnormalities (CA) are more frequent in the infertile population. These men have higher levels of sperm aneuploidy due to the aberrant segregation of the chromosomes involved in the abnormality. The presence of a CA may also influence the segregation of other chromosome…

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Website: http://hdl.handle.net/2429/9705

Author: Kirkpatrick, Gordon

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 2009

Subject: Faculty of Medicine; Theses

Abstract: Male carriers of chromosomal abnormalities (CA) are more frequent in the infertile population. These men have higher levels of sperm aneuploidy due to the aberrant segregation of the chromosomes involved in the abnormality. The presence of a CA may also influence the segregation of other chromosomes, in a process known as in interchromosomal effect (ICE). The behaviour of the CA during meiosis may account for the infertility observed in this population. We studied chromosome segregation, ICE and meiotic defects in a variety of CA. In carriers of CA, we determined the segregation patterns of chromosomes involved in the abnormality.

Language: English

Material Type: Thesis

Call Number: Thesis Shelf

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http://hdl.handle.net/2429/9705