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Implications of BRCA-loss phenotype in epithelial ovarian carcinoma

https://cwslc.andornot.com/en/permalink/catalog113964
Press, Joshua Zephyr. [Vancouver, BC?]: University of British Columbia , 2006.
Website
http://hdl.handle.net/2429/32234
Material Type
Thesis
Call Number
Thesis Shelf
Loss of BRCA1/BRCA2 function through genetic or epigenetic mechanisms is common in epithelial ovarian carcinomas (EOC), but because there are multiple potential mechanisms of loss, the overall frequency is unknown. We characterized loss of BRCA1/BRCA2 at the DNA, RNA and protein level from an unsel…
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Website
http://hdl.handle.net/2429/32234
Author
Press, Joshua Zephyr
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2006
Subject
Faculty of Medicine
Theses
Abstract
Loss of BRCA1/BRCA2 function through genetic or epigenetic mechanisms is common in epithelial ovarian carcinomas (EOC), but because there are multiple potential mechanisms of loss, the overall frequency is unknown. We characterized loss of BRCA1/BRCA2 at the DNA, RNA and protein level from an unselected, consecutive series 49 non-mucinous, invasive EOC. BRCAl-loss was found in 21/49 tumors (43%).
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
http://hdl.handle.net/2429/32234
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