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Characterizations of a tumor-associated antigen COX-1

https://cwslc.andornot.com/en/permalink/catalog113988
Sheu, Fong-Shyong. [Vancouver, BC?]: University of British Columbia , 1991.
Website
http://hdl.handle.net/2429/30332
Material Type
Thesis
Call Number
Thesis Shelf
By using modified hybridoma technology, monoclonal antibodies against an ovarian tumor cell line, OC-3-VGH, were generated in Dr. Lee's laboratory. Among these antibodies, RP 215 was shown to react specifically with a tumor-associated antigen, COX-1. On SDS gel, COX-1 has a molecular weight of 60 K…
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Website
http://hdl.handle.net/2429/30332
Author
Sheu, Fong-Shyong
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1991
Subject
Faculty of Medicine
Theses
Abstract
By using modified hybridoma technology, monoclonal antibodies against an ovarian tumor cell line, OC-3-VGH, were generated in Dr. Lee's laboratory. Among these antibodies, RP 215 was shown to react specifically with a tumor-associated antigen, COX-1. On SDS gel, COX-1 has a molecular weight of 60 KD and exists as an aggregate in the natural- state. A highly purified COX-1 was obtained mainly by immunoaffirtity chromatography, with RP 215 as the affinity ligand, from the shed medium of cultured tumor cells.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
http://hdl.handle.net/2429/30332
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