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Maternal progesterone and fetal cortisol responses to hypoxemia in pregnant sheep

https://cwslc.andornot.com/en/permalink/catalog113981

Wu, Li-Hua. [Vancouver, BC?]: University of British Columbia , 1996.

Website: http://hdl.handle.net/2429/4269

Material Type: Thesis

Call Number: Thesis Shelf

The placenta is an important endocrine organ producing large amounts of steroid and protein hormones which are released into the maternal and fetal circulations. Moreover, it has a very high metabolic rate and consumes a significant proportion of the oxygen and glucose delivered to the uterus and i…

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Website: http://hdl.handle.net/2429/4269

Author: Wu, Li-Hua

Place of Publication: [Vancouver, BC?]

Publisher: University of British Columbia

Publication Date: 1996

Subject: Faculty of Medicine; Theses

Abstract: The placenta is an important endocrine organ producing large amounts of steroid and protein hormones which are released into the maternal and fetal circulations. Moreover, it has a very high metabolic rate and consumes a significant proportion of the oxygen and glucose delivered to the uterus and its contents. However, while there have been many studies on the effects of hypoxemia on fetal cardiovascular, metabolic and endocrine functions, there are limited data on the effects of reduced oxygenation on placental endocrine activities. In the present study, we examined the effects of acute (2-h) moderate (maternal Pao₂ lowered by 27-35%, n=5) and severe (maternal Pao₂ lowered by 41-58%, n=4) hypoxemia on placental progesterone output into the maternal circulation in 7 chronically instrumented pregnant sheep (125 to 136 d). Hypoxemia was achieved by lowering maternal inspired O₂ concentration and the hypoxemia period was preceded and followed by 2 h pre-hypoxia and recovery periods, respectively. Control experiments (n=4), involving 6 h periods of normoxia were also carried out.

Language: English

Material Type: Thesis

Call Number: Thesis Shelf

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http://hdl.handle.net/2429/4269