Author

Abrahams, P.H.

Hutchings, R.T.

Marks Jr, S.C.

Edition

4th ed.

Place of Publication

Philadelphia, PA

Publisher

Mosby

Publication Date

1998

Physical Description

Hardcover: 334 p.

Subject

Anatomy

Anatomy-Atlases. Pictorial Works

Language

English

Material Type

Book

Call Number

REF AC 205 ABR 1998

Copies

Website

http://hdl.handle.net/2429/9760

Author

Ong, Aldrich Dixon

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1999

Subject

Faculty of Medicine

Theses

Abstract

Ovarian cancer is the most lethal gynecological cancer in the Western world, but comparatively little is known about its development. Epithelial ovarian carcinomas are thought to originate in the ovarian surface epithelium (OSE), i.e. the mesothelium covering the ovary, but experimental evidence for this origin has been lacking. Contrary to most epithelia where neoplastic progression is associated with loss of E-cadherin, this cell-cell adhesion molecule is sparse in normal human OSE but its expression increases in ovarian epithelial metaplasia and neoplasia.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/7255

Author

Fan, Nancy C.

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1995

Subject

Faculty of Medicine

Theses

Abstract

The gonadotropin - releasing hormone (GnRH) receptor is a plasma membrane associated receptor and a member of the GTP - binding protein coupled receptor family. The interaction of the ligand, GnRH, and the GnRH receptor is a critical event in the endocrine control of reproduction. This coupling stimulates the synthesis and release of both luteinizing hormone and follicle stimulating hormone from the anterior pituitary. In addition, GnRH - GnRH receptor binding acts locally to regulate human chorionic gonadotropin secretion in the placenta and steroidogenesis in the ovary. The objective of this thesis was to isolate and characterize the gene for the GnRH receptor in human.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/3482

Author

Ge, Hong

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1994

Subject

Faculty of Medicine

Theses

Abstract

This thesis investigated the expression and regulation of cytochrome P450s, aromatase (P450arom) and cholesterol side chain cleavage (P450scc) enzyme mRNAs in human granulosa-luteal cells using reverse transcription-polymerase chain reaction (RT-PCR). The two enzymes are instrumental in steroid hormone biosynthesis.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/6315

Author

Chen, Victor

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1997

Subject

Faculty of Medicine

Theses

Abstract

There is increasing evidence to suggest that activin can function as an autocrine/paracrine regulator in various tissues, including the reproductive system. At the cellular level, activin acts via a family of activin receptor (ActR) subtypes which includes two type I (ActRI and ActRLB) and two type II (II and ILB) receptors. The role of activin in the human placenta is not clearly understood. In this study, the detection of inlubin/activin subunit and ActRI mRNA were examined in first trimester cytotrophoblasts, term cytotrophoblasts, extravillous trophoblast (EVT) cells, immortalized extravillous trophoblast (LEVT) cells, JEG-3 cells, decidual tissue, and decidual cells.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/6811

Author

Vaananen, Jeffrey Eric

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1997

Subject

Faculty of Medicine

Theses

Abstract

These studies examined the effects of prostaglandin-F[sub 2a] (PGF[sub 2a]) on progesterone and 178-estradiol (estradiol) production, as well as DNA and PGF[sub 2a]-receptor (PGF[sub 2a]-R) mRNA levels, in the human granulosa-luteal cell (GLC). Additionally, the interactions of PGF[sub 2a] with human chorionic gonadotrophin (hCG), gonadotrophin-releasing hormone (GnRH) and prostaglandin E₂ (PGE₂) were examined, with respect to progesterone and estradiol production.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/10789

Author

Lee, Pearly S.N.

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1999

Subject

Faculty of Medicine

Theses

Abstract

It is well established that LH action is mediated primarily by adenylate cyclase/cAMP. Conversely, the role of inositol phosphate/calcium in LH signalling has only recently been investigated. We examined the effects of gonadotrophins on intracellular calcium mobilisation in HEK293 cells transiently transfected with human wild type or chimeric gonadotrophs receptors (n=3400). Intracellular free calcium concentration was measured using fura-2 microspectrofluorimetric techniques. Human LH (2-4 μg/ml) arid CG (10 IU/ml) consistently evoked oscillatory calcium signals in HEK293 cells transfected with hLHr, whereas hFSH (2-4 μg/ml) failed to elicit any calcium responses.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf