Website

http://hdl.handle.net/2429/31191

Author

Sakian, Sina

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2011

Subject

Faculty of Medicine

Theses

Abstract

With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures with increased incidence of low birth weight (LBW), chromosomal abnormalities, birth defects and imprinting disorders. No study has proposed a single defined cause for any of these defects in ART infants, however it is believed that they may be due to both the invasiveness of ART and to genetic defects that are at the root of the infertility in the parents. In this study, changes in the methylation of the H19 and IGF2 imprinting control region 1 (ICR1) were investigated for both ART (n=92) and naturally conceived controls (n=19) using pyrosequencing.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://www.selfhelpresource.bc.ca

Corporate Author

Self-Help Resource Association of BC

Edition

15th

Place of Publication

[Vancouver, BC?]

Publisher

Self-Help Resource Association of BC

Publication Date

2007

Physical Description

Paperback: 133 p.

Subject

Directories. Resource Guides

Abstract

Listing of self-help/support groups with offices in Greater Vancouver. Listed alphabetically with the address, telephone number and a brief description of the organization. Includes index.

Language

English

Material Type

Book

Call Number

REF AA 22 SHRA 2007

Copies

Website

http://www.cw.bc.ca/library/pdf/Pamphlets/girlsspeakout.pdf

Website Notes

Click on the link above to view/print.

Author

Godard, Louise

Cory, Jill

Armstrong, Naomi et all.

Editor

Sullivan, Lana

Pederson, Ann

Pigeon, Marguerite

Place of Publication

[Vancouver, BC?]

Publisher

BC Women's Hospital + Health Centre

Publication Date

2016

Physical Description

PDF file, 129 p., ill.

Subject

Violence Prevention

Women's Health

Abstract

This resource provides information about violence and BC Women's Hospital and Health Centre, Girls Speak Out program, its curriculum and some recommended websites about this topic. It's aimed to support women with experiences of violence.

ISBN

0000000001234

Language

English

Material Type

Online

Booklet

Website

http://hdl.handle.net/2429/28984

Author

Feng, Tian Bin

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1990

Subject

Faculty of Medicine

Theses

Abstract

In the present study, the effects of clomiphene citrate (CC) on ovulation, ovarian growth and ovarian steroidogenesis were examined. Ovulation in rats in response to PMSG was completely blocked by administration of three daily treatments of 1.0 mg CC/rat, but was restored by administration of hCG as a preovulatory LH surge substitute. When the number of treatment days was reduced to two days, 1.0 mg of CC enhanced ovulation in response to PMSG, whereas treatment for one day with the same dose of CC did not affect ovulation.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/29326

Author

Yun, Young Won

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1989

Subject

Faculty of Medicine

Theses

Abstract

This study examined primary defects and related mechanisms leading to impaired fertility following superovulation with exogenous gonadotropin. Experiments were designed to address the ovulatory response, oocyte quality (gross morphology and nuclear maturation) and embryo development with reference to ovarian steroid and circulating LH levels in immature rats treated with 4, 20 or 40 IU pregnant mare's serum gonadotropin (PMSG).

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/30417

Author

Van der Weyde, Marlene

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1990

Subject

Faculty of Medicine

Theses

Abstract

Ritodrine is a beta-adrenergic agonist commonly used to inhibit premature labor contractions in women. The primary goal of ritodrine tocolysis is to prolong gestation, however, other indications may include fetal distress. The purpose of the current study was to examine the metabolic and behavioral effects of ritodrine in the fetus, using the chronically instrumented pregnant sheep as an experimental model. Ritodrine was infused continuously into 11 fetal lambs at a rate of 2.6 ug/minute for a period of 8, 12 or 24 hours. Samples were taken simultaneously at predetermined time periods from a fetal femoral artery, umbilical vein, maternal femoral artery and uterine vein for the analysis of fetal and maternal arterial and umbilical and uterine venous blood gases, acid-base status, hematocrit, ritodrine concentration, uterine and umbilical blood flow, and glucose, lactate and oxygen concentrations and fluxes.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/42609

Author

Wu, Elizabeth Xianshi

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2012

Subject

Faculty of Medicine

Theses

Abstract

Pregnancies derived from in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with increased rates of chromosome abnormalities, congenital malformations, low birth weight, pre-term births, multiple gestations, and imprinting disorders. Assisted reproductive technologies (ARTs) enable sub-fertile individuals to circumvent the natural selective pressures involved in human reproduction. The risks of ARTs may be due to the underlying causes of subfertility in these individuals or to the artificial processes used to achieve pregnancy. X-chromosome inactivation (XCI) may be at risk to perturbations in ARTs as it is thought to occur during the blastocyst stage when in vitro culturing would be taking place. We examined the XCI status in females conceived by ICSI (n=70), IVF (n=68), and naturally (NC, n=42).

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/6811

Author

Vaananen, Jeffrey Eric

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1997

Subject

Faculty of Medicine

Theses

Abstract

These studies examined the effects of prostaglandin-F[sub 2a] (PGF[sub 2a]) on progesterone and 178-estradiol (estradiol) production, as well as DNA and PGF[sub 2a]-receptor (PGF[sub 2a]-R) mRNA levels, in the human granulosa-luteal cell (GLC). Additionally, the interactions of PGF[sub 2a] with human chorionic gonadotrophin (hCG), gonadotrophin-releasing hormone (GnRH) and prostaglandin E₂ (PGE₂) were examined, with respect to progesterone and estradiol production.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/30962

Author

Britton, Ann Patricia

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1991

Subject

Faculty of Medicine

Theses

Abstract

A delicate balance of steroid and gonadotrophic hormones is essential for intrafollicular oocyte maturation and successful fertilization and embryonic development. Previous studies have demonstrated that a superovulatory dose of pregnant mare serum gonadotrophin (PMSG) has excessive gonadotrophic activity and alters intrafol1icular steroid hormone levels. In a series of four experiments, the morphology of oocytes and embryos retrieved from immature rats, treated with either a low or high dose of PMSG, and mature, cycling rats was compared to determine whether a superovulatory dose of PMSG has an adverse effect on oocyte maturation and subsequent fertilization and embryonic development in immature rats. Morphological criteria for the assessment of intraoviductal oocyte aging were established in the first experiment.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/28961

Author

Shi, Fengtao

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2010

Subject

Faculty of Medicine

Theses

Abstract

Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regulator of ovarian function, but its overall effects, particularly relating to activin A actions, are unknown. We examined the potential crosstalk between activin A and GDF9 in primary cultures of human granulosa-lutein (hGL) cells. Pretreatment of hGL cells with GDF9 for 24 h resulted in an increased expression of activin receptors and Smad2/3, and decreased inhibitory Smad7 activity. These effects were attenuated by BMP type II receptor ectodomain (BMPR2 ECD), a GDF9 antagonist.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf