Browse and borrow resources that support the learning needs and professional development of C&W staff, clinicians, students and faculty.
Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. …
Human newborns exposed in utero to maternally administered SSRIs such as fluoxetine (FX) have an increased risk of adverse pregnancy outcomes including poor neonatal adaptation. This comprises respiratory difficulty, jitteriness, cyanosis when feeding and persists for several days after birth. Seve…
Aberrant epidermal growth factor receptor (EGFR) activity contributes to the development of epithelial ovarian cancer (EOC), a common and lethal female malignancy. Elucidating the regulation of EGFR function will improve treatments for EOC and the survival of patients. This study aims to elucidate …
Pregnancies derived from in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with increased rates of chromosome abnormalities, congenital malformations, low birth weight, pre-term births, multiple gestations, and imprinting disorders. Assisted reproductive techno…
With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures wi…
Sex hormone-binding globulin (SHBG) binds androgens and estrogens with high affinity, and regulates the distribution of these sex steroids in the blood and other biological fluids. Liver is the primary site of SHBG production, but the human SHBG transcription unit responsible for this is also expre…
The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We ex…
Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA met…
Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regul…
Nuclear receptors including estrogen receptors (ERs) and progesterone receptors (PRs) are activated by their ligands as well as by signaling pathways in response to peptide hormones and growth factors. In gonadotrophs, gonadotropin releasing hormones (GnRHs) act via the GnRH receptor (GnRHR). Both …
It is increasingly apparent that GnRH-II acts as an autocrine/paracrine regulator in non-pituitary tissues, in addition to its role in the regulation of gonadotropin synthesis, and is an important player in cancer cell biology. High levels of GnRH-II and GnRHR in malignant ovarian tumors as compare…
The ADAMTS (A Disintegrin and Metalloproteinase with TromboSpondin Repeats) are a novel family of secreted metalloproteinases. There is increasing evidence that distinct ADAMTS subtypes play key roles in embryonic development, reproduction and cancer. Nineteen ADAMTS subtypes have been identified i…
In-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are two of the most common forms of assisted reproductive technologies (ARTs) used to treat human infertility. Presently, over two million children have been conceived by ART. The majority of these children are born healthy. H…
Copy 1 BC Children's and Women's Study and Learning Commons Thesis Shelf | Available |
This self-directed learning module assists health care professionals working with pregnant women to learn about the knowledge and skills necessary to perform safe and accurate vaginal assessment.
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Happiness is not the belief that we don?t need to change; it is the realization that we can.; Our most commonly held formula for success is broken. Conventional wisdom holds that once we succeed, we?ll be happy; that once we get that great job, win that next promotion, lose those five pounds, happi…
Copy 1 BC Children's and Women's Study and Learning Commons REF | On Loan, due Tuesday, May 14, 2024 | ||
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This resource provides information about violence and BC Women's Hospital and Health Centre, Girls Speak Out program, its curriculum and some recommended websites about this topic. It's aimed to support women with experiences of violence.
The most widely used and highly regarded textbook and reference of emergency medicine -- Endorsed by the American College of Emergency Physicians; The 8th edition of Tintinalli s Emergency Medicine provides the depth and breadth of coverage that reflects the complexity and expertise needed to pract…
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Experience with clinical cases is key to mastering the art and science of medicine. This book provides 60 true-to-life cases that illustrate essential concepts in Internal Medicine. Each case includes a discussion correlated to key concepts, definitions of key terms, clinical pearls, and board-styl…
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This fully updated 4th edition provides an integrated symptom- and issue-based approach with easy access to high yield clinical information. For each topic, carefully organized sections on different diagnoses, investigations, and treatments are designed to facilitate patient care and examination pr…
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Edited by a renowned musculoskeletal radiologist and an internationally recognized Emergency Radiologist, and enhanced by contributions from invited acknowledged authorities, the Fifth Edition of this comprehensive reference is unsurpassed as a source of practical information on imaging of the acut…
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