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The common epithelial ovarian tumors appear to arise from the ovarian surface epithelium (OSE), which is a simple squamous-to-cuboidal meso^helium covering the ovary. The exact mechanism of ovarian tumorigenesis is not well known even though this disease is the most frequent cause of cancer death i…
This comprehensive guide provides educators with the resources needed to implement a Preceptor Development Program in your organization. A series of six workshops, each four hours or less, addresses the learning needs of both beginning and experienced nurse preceptors, learners and hospital staff s…
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This CD-ROM is aimed at junior doctors and medical students, nurses and physiotherapists, general practitioners for revision, and consultations for use as a teaching aid. It includes information on history taking and examination, extensive video images and auscultatory findings of children with res…
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This book presents the work of clinical health care teams and natural work groups, quality improvement teams, committees, and task forces comprising employees in health care settings. It discusses the importance of collaboration and interactive problem-solving among professionals from diverse disci…
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This book is a concrete how-to guide and resource book for planning educational and training programs for adults in a variety of settings, from the corporate sector to educational organizations. It includes new material and examples including the significance of discerning the planning context, the…
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Preeclampsia is a pregnancy-specific condition, and it still remains one of the most common causes of maternal mortality in the developed world. Although the exact cause of preeclampsia has not been identified, it is most widely accepted that preeclampsia results from incomplete placentation. Inter…
Remodeling of the endometrial extracellular matrix, which occurs during the early stages of pregnancy in the human, is mediated by the temporal expression of urokinase-type plasminogen activator (uPA) and matrix metalloproteinases (MMP) in both the maternal and fetal compartments and counterbalance…
Covers the gamut of emergency medicine practice in brief, clinically focused chapters. New to this edition are chapters on bioterroism and weapons of mass destruction, pharmacology of antimicrobials, antifungals, and antivirals, principles of drug interactions, endocarditis, and abdominal and pelvi…
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Pre-eclampsia, which is characterized by maternal hypertension, proteinuria, hypoperfusion of end organs and a systemic maternal innate inflammatory response, is a leading cause of maternal mortality and morbidity world-wide. When of early-onset, pre-eclampsia is associated with fetal intrauterine …
The association between subsets of male infertility, oligoasthenoteratozoospermia (OAT), obstructive azoospermic (OA), non-obstructive azoospermia (NOA), and increased risk of having chromosomal abnormalities in the sperm has not been investigated. Chromosomal aneuploidy in sperm will be systematic…
Pre-eclampsia (PET) continues to contribute to maternal and perinatal morbidity and mortality. Management decisions include an evaluation of maternal risk, which is assisted by expert opinion-based guidelines, while not accounting for gestational age (GA) at diagnosis. We evaluated the feasibility …
n approximately 40% of ovarian cancers, PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) is amplified. This amplification correlates with increased PIK3CA transcription, p110α protein expression, and PI3K activity. Moreover, PIK3CA is implicated as…
Table of contents:; I. PHENOMENOLOGY OF THE TIC DISORDER; 1. Motor and Vocal Tics 1; Stanley Fahn; 2. Premonitory ("Sensory") Experiences 15; Tamara M. Pringsheim and Anthony E. Lang; 3. The Natural History of Gilles de la Tourette Syndrom…
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Volume 1 of this 7th edition contains 36 new chapters and full-color figures and photographs. Compared with the rather limited color-plate photographs in the sixth edition, the color photographs, figures, and tables in each chapter significantly enhance the new text. Informative chapters on the fou…
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Volume 2 of this 7th edition contains 36 new chapters and full-color figures and photographs. Compared with the rather limited color-plate photographs in the sixth edition, the color photographs, figures, and tables in each chapter significantly enhance the new text. Informative chapters on the fou…
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Nursing programs everywhere are looking to evidence-based practice (EBP) with renewed enthusiasm. This is often sparked by an effort to elevate clinical quality and improve outcomes, but nursing programs also turn to EBPs as a way to reinvigorate the practice environment. EBP de-emphasizes ritual o…
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Homeobox genes, which code for families of transcription factors, act at the top of genetic hierarchies. HOX genes specify positional identity during development, and in adult tissues, regulate differentiation and proliferation. Most ovarian carcinomas are derived from the ovarian surface epitheliu…
Loss of BRCA1/BRCA2 function through genetic or epigenetic mechanisms is common in epithelial ovarian carcinomas (EOC), but because there are multiple potential mechanisms of loss, the overall frequency is unknown. We characterized loss of BRCA1/BRCA2 at the DNA, RNA and protein level from an unsel…
Ovarian cancer is the sixth most common cancer and the fifth leading cause of cancer-related death among women in developed countries. There is increasing evidence suggesting that the hormonal environment of the normal ovarian surface epithelium (OSE) and ovarian epithelial cancer (OEC) cells is as…
For clinicians working with patients who have disabilities and may not be able to self-report, recognizing and correctly interpreting expressions of pain can be a challenge. This book, the first to synthesize research about pain in children and adults with a range of developmental disabilities, wil…
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