C&W Library Catalogue
Browse and borrow resources that support the learning needs and professional development of C&W staff, clinicians, students and faculty.
Browse and borrow resources that support the learning needs and professional development of C&W staff, clinicians, students and faculty.
With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures wi…
In-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are two of the most common forms of assisted reproductive technologies (ARTs) used to treat human infertility. Presently, over two million children have been conceived by ART. The majority of these children are born healthy. H…
| Copy 1 BC Children's and Women's Study and Learning Commons Thesis Shelf | Available |
Human newborns exposed in utero to maternally administered SSRIs such as fluoxetine (FX) have an increased risk of adverse pregnancy outcomes including poor neonatal adaptation. This comprises respiratory difficulty, jitteriness, cyanosis when feeding and persists for several days after birth. Seve…
Disruptions or imbalances of the vaginal microbiome can lead to negative reproductive health consequences for women, including an increased risk of sexually transmitted infections, pelvic inflammatory disease, and preterm birth. HIV-positive women may be particularly vulnerable to microbiome disrup…
Aberrant epidermal growth factor receptor (EGFR) activity contributes to the development of epithelial ovarian cancer (EOC), a common and lethal female malignancy. Elucidating the regulation of EGFR function will improve treatments for EOC and the survival of patients. This study aims to elucidate …
Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. …
Sex hormone-binding globulin (SHBG) binds androgens and estrogens with high affinity, and regulates the distribution of these sex steroids in the blood and other biological fluids. Liver is the primary site of SHBG production, but the human SHBG transcription unit responsible for this is also expre…
The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We ex…
Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA met…
Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regul…
Nuclear receptors including estrogen receptors (ERs) and progesterone receptors (PRs) are activated by their ligands as well as by signaling pathways in response to peptide hormones and growth factors. In gonadotrophs, gonadotropin releasing hormones (GnRHs) act via the GnRH receptor (GnRHR). Both …
It is increasingly apparent that GnRH-II acts as an autocrine/paracrine regulator in non-pituitary tissues, in addition to its role in the regulation of gonadotropin synthesis, and is an important player in cancer cell biology. High levels of GnRH-II and GnRHR in malignant ovarian tumors as compare…
The ADAMTS (A Disintegrin and Metalloproteinase with TromboSpondin Repeats) are a novel family of secreted metalloproteinases. There is increasing evidence that distinct ADAMTS subtypes play key roles in embryonic development, reproduction and cancer. Nineteen ADAMTS subtypes have been identified i…
This thesis work is focused on studies of sperm antigen: its purification and antifertility effect, its "internal image" by use of anti-idiotypic antibodies, and its capacity to induce antibodies of IgA class. Mouse sperm acrosomal antigens that react with a monoclonal antibody generated against mo…
The present study was conducted to investigate the hypothesis that membrane phosphoinositide breakdown may participate in the actions of luteinizing hormone-releasing hormone (LHRH) on hormone production in the rat ovary. In granulosa cells prelabeled with [³H]-arachidonic acid or [³H]-inositol, tr…
This study examined primary defects and related mechanisms leading to impaired fertility following superovulation with exogenous gonadotropin. Experiments were designed to address the ovulatory response, oocyte quality (gross morphology and nuclear maturation) and embryo development with reference …
An excitatory role for norepinephrine (NE) in the regulation of luteinizing hormone (LH) release was first suggested when it was demonstrated that noradrenergic receptor antagonists were able to block ovulation. More recently it has been proposed that NE has both an excitatory role and an inhibitor…
Covering the evaluation and management of every key disease and condition affecting newborns,Avery's Diseases of the Newborn, by Drs. Christine A. Gleason and Sandra E. Juul, remainsyour #1 source for practical, clinically relevant information in this fast-changing field. You'll find thespecific st…
| Copy 1 BC Children's and Women's Study and Learning Commons REF | On Loan, due Tuesday, January 30, 2024 |
Provides information and clinical guidance on treatment for diseases affecting newborns. This edition includes coverage of topics such as MRSA, neonatal pain, cardiovascular fetal interventions, care of the late preterm infant, and the developing intestinal microbiome.
| Copy 1 BC Children's and Women's Study and Learning Commons REF | Available |
Completely updated and revised. Are emails keeping you in the office late at night? Is your desk overflowing with things to read and process? Are you overwhelmed by loose ends and unfinished projects? Do you despair of finding time to concentrate on the bigger picture? This book offers powerful, pr…
| Copy 5 BC Children's and Women's Study and Learning Commons | On Loan, due Wednesday, October 4, 2023 | ||
| Copy 9 BC Children's and Women's Study and Learning Commons | On Loan, due Wednesday, May 25, 2022 | ||
| Copy 10 BC Children's and Women's Study and Learning Commons | On Loan, due Wednesday, May 3, 2017 | ||
| Copy 1 BC Children's and Women's Study and Learning Commons | Available | ||
| Copy 2 BC Children's and Women's Study and Learning Commons | Available | ||
| Copy 3 BC Children's and Women's Study and Learning Commons | Available | ||
| Copy 4 BC Children's and Women's Study and Learning Commons | Available | ||
| Copy 6 BC Children's and Women's Study and Learning Commons | Available | ||
| Copy 7 BC Children's and Women's Study and Learning Commons | Available | ||
| Copy 8 BC Children's and Women's Study and Learning Commons | Available |
