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DNA methylation at imprinted and non-imprinted genes in the sperm of men affected by severe male factor infertility

https://cwslc.andornot.com/en/permalink/catalog113950
Minor, Agata. [Vancouver, BC?]: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/29282
Material Type
Thesis
Call Number
Thesis Shelf
Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA met…
Website
http://hdl.handle.net/2429/29282
Author
Minor, Agata
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA methylation would be present in the ejaculate and testicular sperm of men affected by severe male factor infertility compared to that in fertile control men. Furthermore, we hypothesized abnormal DNA methylation would also affect non-imprinted genes in the sperm of men affected by severe oligozoospermia.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Effects and mechanisms of growth differentiation factor 9 on activin A-regulated inhibin B and progesterone production in human granulosa cells

https://cwslc.andornot.com/en/permalink/catalog113951
Shi, Fengtao. [Vancouver, BC?]: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/28961
Material Type
Thesis
Call Number
Thesis Shelf
Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regul…
Website
http://hdl.handle.net/2429/28961
Author
Shi, Fengtao
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regulator of ovarian function, but its overall effects, particularly relating to activin A actions, are unknown. We examined the potential crosstalk between activin A and GDF9 in primary cultures of human granulosa-lutein (hGL) cells. Pretreatment of hGL cells with GDF9 for 24 h resulted in an increased expression of activin receptors and Smad2/3, and decreased inhibitory Smad7 activity. These effects were attenuated by BMP type II receptor ectodomain (BMPR2 ECD), a GDF9 antagonist.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Ligand-independent activation of steroid hormone receptors by gonadotropin-releasing hormone

https://cwslc.andornot.com/en/permalink/catalog113952
Chen, Junling. [Vancouver, BC?]: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/34980
Material Type
Thesis
Call Number
Thesis Shelf
Nuclear receptors including estrogen receptors (ERs) and progesterone receptors (PRs) are activated by their ligands as well as by signaling pathways in response to peptide hormones and growth factors. In gonadotrophs, gonadotropin releasing hormones (GnRHs) act via the GnRH receptor (GnRHR). Both …
Website
http://hdl.handle.net/2429/34980
Author
Chen, Junling
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
Nuclear receptors including estrogen receptors (ERs) and progesterone receptors (PRs) are activated by their ligands as well as by signaling pathways in response to peptide hormones and growth factors. In gonadotrophs, gonadotropin releasing hormones (GnRHs) act via the GnRH receptor (GnRHR). Both GnRH-I and GnRH-II activate an estrogen response element (ERE)-driven luciferase reporter gene in LβT2 mouse pituitary cells, and GnRH-I is more potent in this regard.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Human gonadotropin-releasing hormone-II regulation in ovarian cancer : mechanisms and potential functional role

https://cwslc.andornot.com/en/permalink/catalog113953
Poon, Song Ling. [Vancouver, BC?]: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/30021
Material Type
Thesis
Call Number
Thesis Shelf
It is increasingly apparent that GnRH-II acts as an autocrine/paracrine regulator in non-pituitary tissues, in addition to its role in the regulation of gonadotropin synthesis, and is an important player in cancer cell biology. High levels of GnRH-II and GnRHR in malignant ovarian tumors as compare…
Website
http://hdl.handle.net/2429/30021
Author
Poon, Song Ling
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
It is increasingly apparent that GnRH-II acts as an autocrine/paracrine regulator in non-pituitary tissues, in addition to its role in the regulation of gonadotropin synthesis, and is an important player in cancer cell biology. High levels of GnRH-II and GnRHR in malignant ovarian tumors as compared with benign ovarian tissues underlies the importance of understanding GnRH-II function in ovarian cancer. In an attempt to define the regulation of GnRH-II in these tissues, we found that a cyclic-AMP responsive element (CRE) is critical for GnRH-II promoter transcription.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Regulated expression of aggrecanases of ADAMTS family in endometrial physiology and pathology

https://cwslc.andornot.com/en/permalink/catalog113954
Wen, Jiadi. [Vancouver, BC?]: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/30478
Material Type
Thesis
Call Number
Thesis Shelf
The ADAMTS (A Disintegrin and Metalloproteinase with TromboSpondin Repeats) are a novel family of secreted metalloproteinases. There is increasing evidence that distinct ADAMTS subtypes play key roles in embryonic development, reproduction and cancer. Nineteen ADAMTS subtypes have been identified i…
Website
http://hdl.handle.net/2429/30478
Author
Wen, Jiadi
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
The ADAMTS (A Disintegrin and Metalloproteinase with TromboSpondin Repeats) are a novel family of secreted metalloproteinases. There is increasing evidence that distinct ADAMTS subtypes play key roles in embryonic development, reproduction and cancer. Nineteen ADAMTS subtypes have been identified in humans but most of them have been characterized only at the structural level. ADAMTS-1, -4, -5, -8, -9 and -15 have been subclassified into a subfamily, known as aggrecanases, owing to their ability to cleave the important extracellular matrix components, versican and aggrecan.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Washington manual of medical therapeutics

https://cwslc.andornot.com/en/permalink/catalog112679
Foster, Cory, Mistry, Neville, F. Philadelphia, PA: Lippincott Williams & Wilkins , 2010. 33rd Ed.
Material Type
Book
Call Number
REF FA 100 FOS 2010
Availability
1 copy, 1 available
Portable and comprehensive quick-reference style handbook for interns, residents, medical students and other practioners in need of practical clinical information.
Author
Foster, Cory
Mistry, Neville, F.
Edition
33rd Ed.
Place of Publication
Philadelphia, PA
Publisher
Lippincott Williams & Wilkins
Publication Date
2010
Physical Description
Paperback; 1064 pages.
Subject
General Medicine
UBC MD Undergrad
Abstract
Portable and comprehensive quick-reference style handbook for interns, residents, medical students and other practioners in need of practical clinical information.
ISBN
978-1608310036
Language
English
Material Type
Book
Call Number
REF FA 100 FOS 2010

Copies

Copy 1 BC Children's and Women's Study and Learning Commons MISSING Available
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Investigation of methylation and gene expression in placenta of pregnancies conceived by assisted reproductive technology (ART)

https://cwslc.andornot.com/en/permalink/catalog113947
Sakian, Sina. [Vancouver, BC?]: University of British Columbia , 2011.
Website
http://hdl.handle.net/2429/31191
Material Type
Thesis
Call Number
Thesis Shelf
With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures wi…
Website
http://hdl.handle.net/2429/31191
Author
Sakian, Sina
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2011
Subject
Faculty of Medicine
Theses
Abstract
With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures with increased incidence of low birth weight (LBW), chromosomal abnormalities, birth defects and imprinting disorders. No study has proposed a single defined cause for any of these defects in ART infants, however it is believed that they may be due to both the invasiveness of ART and to genetic defects that are at the root of the infertility in the parents. In this study, changes in the methylation of the H19 and IGF2 imprinting control region 1 (ICR1) were investigated for both ART (n=92) and naturally conceived controls (n=19) using pyrosequencing.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Regulation of androgen action by sex hormone-binding globulin

https://cwslc.andornot.com/en/permalink/catalog113948
Hong, Eui-ju. [Vancouver, BC?]: University of British Columbia , 2011.
Website
http://hdl.handle.net/2429/35861
Material Type
Thesis
Call Number
Thesis Shelf
Sex hormone-binding globulin (SHBG) binds androgens and estrogens with high affinity, and regulates the distribution of these sex steroids in the blood and other biological fluids. Liver is the primary site of SHBG production, but the human SHBG transcription unit responsible for this is also expre…
Website
http://hdl.handle.net/2429/35861
Author
Hong, Eui-ju
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2011
Subject
Faculty of Medicine
Theses
Abstract
Sex hormone-binding globulin (SHBG) binds androgens and estrogens with high affinity, and regulates the distribution of these sex steroids in the blood and other biological fluids. Liver is the primary site of SHBG production, but the human SHBG transcription unit responsible for this is also expressed in proximal convoluted tubule (PCT) epithelial cells in a transgenic mouse model. Unlike hepatocytes which actively secrete SHBG and retain little immunoreactive SHBG within their cytoplasm, an incompletely glycosylated SHBG isoform has been found to accumulate inside PCT cells. These cells are androgen target cells, and the presence of SHBG within them accentuates androgen-dependent regulation of gene expression mediated by the androgen receptor (AR).
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Deja review: Family medicine

https://cwslc.andornot.com/en/permalink/catalog112735
Perez, Mayra, Liaw, Winston, Botsford, Lindsay. New York, NY: McGraw-Hill Companies, Inc. , 2011. 2nd Ed.
Material Type
Book
Call Number
REF FA 310 PER 2011
Availability
1 copy, 1 available
This text boils down your coursework to just the critical concepts you need to know for exam success. Features a quick-read, two-column, “flashcard in a book” Q&A format. – specifically designed to help you remember a large amount of pertinent information in the least amount of time possible. The f…
Author
Perez, Mayra
Liaw, Winston
Botsford, Lindsay
Edition
2nd Ed.
Place of Publication
New York, NY
Publisher
McGraw-Hill Companies, Inc.
Publication Date
2011
Physical Description
Paperback, 402 pages.
Subject
Family Medicine
Medical Directories. Resource Guides
Family Medicine-Directories.Resource Guides
UBC MD Undergrad
Abstract
This text boils down your coursework to just the critical concepts you need to know for exam success. Features a quick-read, two-column, “flashcard in a book” Q&A format. – specifically designed to help you remember a large amount of pertinent information in the least amount of time possible. The format allows you to zero-in on only the correct answers to promote memory retention and get the most out of your study time. Deja Review provides a straightforward way for you to assess your strengths and weaknesses so you can excel on the clerkship and the USMLE Step 2 CK.
ISBN
978-0-07-171515-7
Language
English
Material Type
Book
Call Number
REF FA 310 PER 2011

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Deja review: Emergency Medicine

https://cwslc.andornot.com/en/permalink/catalog112738
Jang, David H. New York, NY: McGraw-Hill Companies, Inc. , 2011. 2nd Ed.
Material Type
Book
Call Number
REF EB 822 JAN 2011
Availability
1 copy, 1 available
This text boils down your coursework to just the critical concepts you need to know for exam success. This unbeatable guide features a quick-read, two-column, “flashcard in a book” Q&A format. – specifically designed to help you remember a large amount of pertinent information in the least amount o…
Author
Jang, David H.
Edition
2nd Ed.
Place of Publication
New York, NY
Publisher
McGraw-Hill Companies, Inc.
Publication Date
2011
Physical Description
Paperback: 480 pages
Subject
Emergency Medicine-Directories. Thesauri. Glossaries
Medical Directories. Resource Guides
UBC MD Undergrad
Abstract
This text boils down your coursework to just the critical concepts you need to know for exam success. This unbeatable guide features a quick-read, two-column, “flashcard in a book” Q&A format. – specifically designed to help you remember a large amount of pertinent information in the least amount of time possible. The format allows you to zero-in on only the correct answers to promote memory retention and get the most out of your study time. Deja Review provides a straightforward way for you to assess your strengths and weaknesses so you can excel on the clerkship and the USMLE Step 2 CK.
ISBN
978-0071715188
Language
English
Material Type
Book
Call Number
REF EB 822 JAN 2011

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Deja review: Internal medicine

https://cwslc.andornot.com/en/permalink/catalog112754
Mobasser, Sarvenaz S. Saadat. New York, NY: McGraw-Hill Companies, Inc. , 2011. 2nd Ed.
Material Type
Book
Call Number
REF AB 60 MOB 2011
Availability
2 copies, 2 available
This text boils down your coursework to just the critical concepts you need to know for exam success. This unbeatable guide features a quick-read, two-column, “flashcard in a book” Q&A format. – specifically designed to help you remember a large amount of pertinent information in …
Author
Mobasser, Sarvenaz S. Saadat
Edition
2nd Ed.
Place of Publication
New York, NY
Publisher
McGraw-Hill Companies, Inc.
Publication Date
2011
Physical Description
Paperback: 254 pages.
Subject
Internal Medicine
Medical Directories. Resource Guides
UBC MD Undergrad
Abstract
This text boils down your coursework to just the critical concepts you need to know for exam success. This unbeatable guide features a quick-read, two-column, “flashcard in a book” Q&A format. – specifically designed to help you remember a large amount of pertinent information in the least amount of time possible. The format allows you to zero-in on only the correct answers to promote memory retention and get the most out of your study time. Deja Review provides a straightforward way for you to assess your strengths and weaknesses so you can excel on the clerkship and the USMLE Step 2 CK.
ISBN
978-0071715171
Language
English
Material Type
Book
Call Number
REF AB 60 MOB 2011

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
Copy 2 BC Children's and Women's Study and Learning Commons REF Available
Images
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Blueprints: Family medicine

https://cwslc.andornot.com/en/permalink/catalog112766
Lipsky, Martin S., King, Mitchell S. Baltimore, MD: Lippincott Williams & Wilkins, a Wolters Kluwer business , 2011. 3rd Ed.
Material Type
Book
Call Number
REF FA 310 LIP 2010
Availability
1 copy, 1 available
This resource provides students with a complete review of key concepts and topics and serves as a rapid reference during day-to-day activities in patient care—perfect for clerkship rotations and the USMLE.
Author
Lipsky, Martin S.
King, Mitchell S.
Edition
3rd Ed.
Place of Publication
Baltimore, MD
Publisher
Lippincott Williams & Wilkins, a Wolters Kluwer business
Publication Date
2011
Physical Description
Paperback: 329 pages
Subject
Family Medicine-Directories. Resource Guides
Medical Directories. Resource Guides
UBC MD Undergrad
Abstract
This resource provides students with a complete review of key concepts and topics and serves as a rapid reference during day-to-day activities in patient care—perfect for clerkship rotations and the USMLE.
ISBN
978-1608310876
Language
English
Material Type
Book
Call Number
REF FA 310 LIP 2010

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Lange Q&A: Internal medicine

https://cwslc.andornot.com/en/permalink/catalog112769
Patel, Yashesh. New York, NY: McGraw-Hill , 2011. 5th Ed.
Material Type
Book
Call Number
REF AB 60 PAT 2011
Availability
1 copy, 1 available
This text features more than 1000 USMLE-style questions and answers with concise but comprehensive explanations of correct and incorrect answer options. This review simulates the test-taking experience by including almost 100% clinical vignette questions and updates on the latest patient management…
Author
Patel, Yashesh
Edition
5th Ed.
Place of Publication
New York, NY
Publisher
McGraw-Hill
Publication Date
2011
Physical Description
Paperback: 340 pages
Subject
Internal Medicine
Medical Directories. Resource Guides
UBC MD Undergrad
Abstract
This text features more than 1000 USMLE-style questions and answers with concise but comprehensive explanations of correct and incorrect answer options. This review simulates the test-taking experience by including almost 100% clinical vignette questions and updates on the latest patient management and treatment options. The questions are selected to match the style and difficulty level of what students will see on the actual exam. Answers are referenced to authoritative texts and seminal articles for further reading.
ISBN
978-0071703468
Language
English
Material Type
Book
Call Number
REF AB 60 PAT 2011

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Approach to internal medicine: A resource book for clinical practice

https://cwslc.andornot.com/en/permalink/catalog113342
Hui, David, Leung, Alexander, Padwal, Raj. New York, NY: Springer , 2011. 3rd ed.
Material Type
Book
Call Number
REF AB 60 HUI 2011
Availability
1 copy, 1 available
This book is written by trainees in internal medicine who understand the need for rapid access to accurate and concise clinical information. It has a practical approach to clinical problem solving.
Author
Hui, David
Leung, Alexander
Padwal, Raj
Edition
3rd ed.
Place of Publication
New York, NY
Publisher
Springer
Publication Date
2011
Subject
Internal Medicine -- Handbooks
UBC MD Undergrad
Abstract
This book is written by trainees in internal medicine who understand the need for rapid access to accurate and concise clinical information. It has a practical approach to clinical problem solving.
ISBN
9781441965042
Language
English
Material Type
Book
Call Number
REF AB 60 HUI 2011

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Patient safety: A human factors approach

https://cwslc.andornot.com/en/permalink/catalog113868
Dekker, Sidney. Boca Raton, Fla.: CRC Press , 2011.
Material Type
Book
Call Number
REF JB 205 DEK 2011
Availability
1 copy, 1 available
Increased concern for patient safety has put the issue at the top of the agenda of practitioners, hospitals, and even governments. The risks to patients are many and diverse, and the complexity of the healthcare system that delivers them is huge. Yet the discourse is often oversimplified and underd…
Author
Dekker, Sidney
Place of Publication
Boca Raton, Fla.
Publisher
CRC Press
Publication Date
2011
Physical Description
Softcover, 262 p.
Subject
Safety
Hospital Safety
Abstract
Increased concern for patient safety has put the issue at the top of the agenda of practitioners, hospitals, and even governments. The risks to patients are many and diverse, and the complexity of the healthcare system that delivers them is huge. Yet the discourse is often oversimplified and underdeveloped. Written from a scientific, human factors perspective, Patient Safety: A Human Factors Approach delineates a method that can enlighten and clarify this discourse as well as put us on a better path to correcting the issues.
ISBN
9781439852255
Language
English
Material Type
Book
Call Number
REF JB 205 DEK 2011

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Investigation of confined placental mosaicism and aberrant H19/ IGF2 imprinting in pregnancies conceived by in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI)

https://cwslc.andornot.com/en/permalink/catalog113955
Chan Wong, Edgar Antonio. [Vancouver, BC?]: University of British Columbia , 2011.
Website
http://hdl.handle.net/2429/33832
Material Type
Thesis
Call Number
Thesis Shelf
Availability
1 copy, 1 available
In-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are two of the most common forms of assisted reproductive technologies (ARTs) used to treat human infertility. Presently, over two million children have been conceived by ART. The majority of these children are born healthy. H…
Website
http://hdl.handle.net/2429/33832
Author
Chan Wong, Edgar Antonio
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2011
Subject
Faculty of Medicine
Theses
Abstract
In-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are two of the most common forms of assisted reproductive technologies (ARTs) used to treat human infertility. Presently, over two million children have been conceived by ART. The majority of these children are born healthy. However, IVF and ICSI have been associated with increased risks of adverse perinatal health outcomes. The higher risk of low birth weight, intrauterine growth restriction, and small for gestational age are of special concern due to its association with adult-onset diseases. In this thesis project, the effect of ART on the genetic and epigenetic status of the placenta, and their associations with fetal growth restriction are examined.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf

Copies

Copy 1 BC Children's and Women's Study and Learning Commons Thesis Shelf Available
Websites
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Crisis Management in Acute Care Settings: Human Factors, Team Psychology, and Patient Safety in a High Stakes Environment

https://cwslc.andornot.com/en/permalink/catalog114233
St. Pierre, Michael, Buerschaper, Cornelius, Simon, Robert. Berlin, Germany: Springer-Verlag , 2011. 2nd Ed.
Material Type
Book
Call Number
REF EB 800 STP 2011
Availability
1 copy, 1 available
Critical situations in acute and emergency care are one of the great clinical challenges because of the uncertainty, high stakes, time pressure, and stress that are involved. This book provides a comprehensive outline of all the human factors issues relevant to patient safety during acute care. Fol…
Author
St. Pierre, Michael
Buerschaper, Cornelius
Simon, Robert
Edition
2nd Ed.
Place of Publication
Berlin, Germany
Publisher
Springer-Verlag
Publication Date
2011
Physical Description
Hardcover: 346 pages
Subject
Emergency Care Services. Emergency Room. ER
Emergency Medicine
Safety
Abstract
Critical situations in acute and emergency care are one of the great clinical challenges because of the uncertainty, high stakes, time pressure, and stress that are involved. This book provides a comprehensive outline of all the human factors issues relevant to patient safety during acute care. Following an initial section discussing the basic principles of human behavior and decision making, the various influences on safe patient care are discussed in depth. These are divided into three interacting groups: individual factors, team factors, and organizational factors. Relevant psychological theories are carefully examined, and case studies and descriptions of proven strategies help to ground these theories in daily practice. This newly revised edition will help both physicians and non-physicians to better understand the principles of human behavior and decision making in critical situations and thus to provide safer treatment.
ISBN
9783642196997
Language
English
Material Type
Book
Call Number
REF EB 800 STP 2011

Copies

Copy 1 BC Children's and Women's Study and Learning Commons Available
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Role of receptor tyrosine kinase regulator Sprouty in ovarian cancer cells

https://cwslc.andornot.com/en/permalink/catalog113944
So, Wai Kin. [Vancouver, BC?]: University of British Columbia , 2012.
Website
http://hdl.handle.net/2429/42242
Material Type
Thesis
Call Number
Thesis Shelf
Aberrant epidermal growth factor receptor (EGFR) activity contributes to the development of epithelial ovarian cancer (EOC), a common and lethal female malignancy. Elucidating the regulation of EGFR function will improve treatments for EOC and the survival of patients. This study aims to elucidate …
Website
http://hdl.handle.net/2429/42242
Author
So, Wai Kin
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2012
Subject
Faculty of Medicine
Theses
Abstract
Aberrant epidermal growth factor receptor (EGFR) activity contributes to the development of epithelial ovarian cancer (EOC), a common and lethal female malignancy. Elucidating the regulation of EGFR function will improve treatments for EOC and the survival of patients. This study aims to elucidate the role of Sprouty (SPRY) proteins, which are EGFR regulators, in EOC.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
Show Less

X-chromosome inactivation and FMR1 CGG repeat and AGG interspersion number in female newborns conceived by assisted reproductive technologies (ARTs)

https://cwslc.andornot.com/en/permalink/catalog113945
Wu, Elizabeth Xianshi. [Vancouver, BC?]: University of British Columbia , 2012.
Website
http://hdl.handle.net/2429/42609
Material Type
Thesis
Call Number
Thesis Shelf
Pregnancies derived from in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with increased rates of chromosome abnormalities, congenital malformations, low birth weight, pre-term births, multiple gestations, and imprinting disorders. Assisted reproductive techno…
Website
http://hdl.handle.net/2429/42609
Author
Wu, Elizabeth Xianshi
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2012
Subject
Faculty of Medicine
Theses
Abstract
Pregnancies derived from in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with increased rates of chromosome abnormalities, congenital malformations, low birth weight, pre-term births, multiple gestations, and imprinting disorders. Assisted reproductive technologies (ARTs) enable sub-fertile individuals to circumvent the natural selective pressures involved in human reproduction. The risks of ARTs may be due to the underlying causes of subfertility in these individuals or to the artificial processes used to achieve pregnancy. X-chromosome inactivation (XCI) may be at risk to perturbations in ARTs as it is thought to occur during the blastocyst stage when in vitro culturing would be taking place. We examined the XCI status in females conceived by ICSI (n=70), IVF (n=68), and naturally (NC, n=42).
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Noninvasive assessment of embryo quality in human in vitro fertilization : metabolomic profiling of embryo culture media with Raman spectroscopy

https://cwslc.andornot.com/en/permalink/catalog113946
Asghari Roodsari, Alaleh. [Vancouver, BC?]: University of British Columbia , 2012.
Website
http://hdl.handle.net/2429/43273
Material Type
Thesis
Call Number
Thesis Shelf
Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. …
Website
http://hdl.handle.net/2429/43273
Author
Asghari Roodsari, Alaleh
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2012
Subject
Faculty of Medicine
Theses
Abstract
Light microscopy has remained the primary tool for the assessment of embryo quality and the selection of embryos for transfer in clinical IVF practice. Recent studies have suggested that metabolomic profiling of embryo culture media can distinguish human embryos with better implantation potential. We therefore undertook the following study to further assess the usefulness of metabolomic profiling ?spent? embryo culture medium using Raman spectroscopy. Methods: Patients undergoing IVF+/-ICSI treatment from the UBC Centre for Reproductive Health were recruited for study.
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