Website

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http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=AC_T_B&C=Gene+Therapy

Place of Publication

Baltimore, MD

Publisher

Nature Publishing Group

Publication Date

1994 - Present

ISSN

0969-7128

Language

English

Material Type

Serial

Frequency

Monthly

Holdings

CFRI/Study & Learning Commons - Print: v.1:2-v.12:14,17,19-22,24 (1994-2005); + suppls.

Missing: v.8:23 (2001); v.9:5,8,20,24 (2002); v.10:22-26 (2003); v.11:11,15,19,20 (2004); v.12:1,3,5,15,16,18,23 (2005).

Online: 1997 to present.

Website

http://hdl.handle.net/2429/32051

Author

Peng, Gang

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2007

Subject

Faculty of Medicine

Theses

Abstract

Pre-eclampsia remains one of the most common causes of maternal mortality in the developed world, and we still have no known effective prophylaxis and proven modifiers. The recent successful clinical trial of recombinant human activated protein C (rhAPC) in the management of SIRS (systemic inflammatory response syndrome) has drawn attention to the possible use of this medicine for other conditions. Pre-eclampsia, has remarkable similarity to SIRS and may be such a condition.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

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http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=I_M&C=1525-0016

Place of Publication

Maryland Heights, Mo.

Publisher

Elsevier Inc.

Publication Date

2000 - Present.

ISSN

1525-0016

Material Type

Serial

Frequency

Monthly

Holdings

CFRI/Study & Learning Commons - Print: v.1:1-v.4:6 (2000-2001); v.7:1-v.8:3 (2003); v.9:1-2 (2004); v.11:1-5;v.12:1,3-6 (2005); v.13:1-2 + suppls. (2006).

Online: 2000 to present.

Website

http://hdl.handle.net/2429/7255

Author

Fan, Nancy C.

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1995

Subject

Faculty of Medicine

Theses

Abstract

The gonadotropin - releasing hormone (GnRH) receptor is a plasma membrane associated receptor and a member of the GTP - binding protein coupled receptor family. The interaction of the ligand, GnRH, and the GnRH receptor is a critical event in the endocrine control of reproduction. This coupling stimulates the synthesis and release of both luteinizing hormone and follicle stimulating hormone from the anterior pituitary. In addition, GnRH - GnRH receptor binding acts locally to regulate human chorionic gonadotropin secretion in the placenta and steroidogenesis in the ovary. The objective of this thesis was to isolate and characterize the gene for the GnRH receptor in human.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://www.ncbi.nlm.nih.gov/omim

Website Notes

The database corresponds to the print publication.

Author

McKusiak, Victor A (Ed).

Edition

12th Ed.

Place of Publication

Baltimore, MD

Publisher

Johns Hopkins University Press

Publication Date

1998

Physical Description

Hardcover

Subject

Genetics

Genetic Disorders

Genetics/Genetic Disorders-Encyclopedias

Abstract

A comprehensive, authoritative and timely knowledgebase of human genes and genetic disorders compiled to support human genetics research and education and the practice of clinical genetics.

ISBN

0801857422

Language

English

Material Type

Book

Call Number

REF GI 20 MCK 1998 VOL 1

Copies

Website

http://www.ncbi.nlm.nih.gov/omim

Website Notes

The database corresponds to the print publication.

Author

McKusiak, Victor A (Ed).

Edition

12th Ed.

Place of Publication

Baltimore, MD

Publisher

Johns Hopkins University Press

Publication Date

1998

Physical Description

Hardcover

Subject

Genetics

Genetics/Genetic Disorders-Encyclopedias

Genetic Disorders

Abstract

A comprehensive, authoritative and timely knowledgebase of human genes and genetic disorders compiled to support human genetics research and education and the practice of clinical genetics.

ISBN

0801857422

Language

English

Material Type

Book

Call Number

REF GI 20 MCK 1998 VOL 2

Copies

Website

http://www.ncbi.nlm.nih.gov/omim

Website Notes

The database corresponds to the print publication.

Author

McKusiak, Victor A (Ed).

Place of Publication

Baltimore, MD

Publisher

Johns Hopkins University Press

Publication Date

1998

Physical Description

Hardcover

Subject

Genetic Disorders

Genetics

Genetics/Genetic Disorders-Encyclopedias

Abstract

A comprehensive, authoritative and timely knowledgebase of human genes and genetic disorders compiled to support human genetics research and education and the practice of clinical genetics.

ISBN

0801857422

Language

English

Material Type

Book

Call Number

REF GI 20 MCK 1998 VOL 3

Copies

Website

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http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=AC_T_B&C=Genes+%26+Development

Alternate Title

Genes and development

Corporate Author

Cold Spring Harbor Laboratory.

Genetical Society (Great Britain)

Place of Publication

Cold Spring Harbor, N.Y.

Publisher

Cold Spring Harbor Laboratory Press

Publication Date

1987 - Present

ISSN

0890-9369

Language

English

Material Type

Serial

Frequency

Biweekly

Holdings

CFRI/Study & Learning Commons - Print: v.8:4-v.17:17 (1994-2003).

Missing: v.8:6 (1994); v.9:5 (1995); v.13:21 (1999); v.14:22 (2000); v.15:13,16,18,24 (2001); v.16:1,6 (2002).

Online: 1987 to present.

Website

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http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=AC_T_B&C=Genes%2C+Brain+and+Behavior

Alternate Title

G2B

Corporate Author

International Behavioural and Neural Genetics Society

Place of Publication

Malden, Ma.

Publisher

Wiley-Blackwell

Publication Date

2002 - Present

ISSN

1601-1848

Language

English

Material Type

Serial

Frequency

Irregular or Other

Holdings

CFRI/Study & Learning Commons - Print: v.3-v.6:8 (2004-2007).

Online: 2002 to present.

Website

http://hdl.handle.net/2429/31191

Author

Sakian, Sina

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2011

Subject

Faculty of Medicine

Theses

Abstract

With the increasing use of assisted reproductive techniques (ART) every year, concerns have been raised regarding the possible effect these procedures have on the health of the children procured by them. Although patients born via ART are usually healthy, studies have associated these procedures with increased incidence of low birth weight (LBW), chromosomal abnormalities, birth defects and imprinting disorders. No study has proposed a single defined cause for any of these defects in ART infants, however it is believed that they may be due to both the invasiveness of ART and to genetic defects that are at the root of the infertility in the parents. In this study, changes in the methylation of the H19 and IGF2 imprinting control region 1 (ICR1) were investigated for both ART (n=92) and naturally conceived controls (n=19) using pyrosequencing.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

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Place of Publication

Oxford, England

Publisher

Oxford University Press

Publication Date

1992 - Present

ISSN

0964-6906

Language

English

Material Type

Serial

Frequency

Bimonthly

Holdings

CFRI/Study & Learning Commons - Print: v.3:1-v.8:13 (1994-1999); v.9:15-16 (2000); v.10:1-16,19,20,22-25 (2001); v.11:17,20 (2002); v.12:13 (2003).

Missing: v.4:8 (1995); v.5:8 (1996); v.6:8,10 (1997).

Online: 1992 to present.

Website

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UBC Users:

http://gw2jh3xr2c.search.serialssolutions.com/?sid=sersol&SS_jc=AMERJOUROFHU&title=American%20journal%20of%20human%20genetics

Alternate Title

AJHG

Corporate Author

The American Society of Human Genetics

Publisher

Cell Press

ISSN

0002-9297

Material Type

Serial

Frequency

Monthly

Holdings

CFRI/Study & Learning Commons - Print: v.4:1-v.97:6 (1994-2012);

v.93:12-v.94:1 + suppls. (2013-2014)

Missing: v.59:3-5 (1996); v.61:1(1997); v.80:2(2007); v.85:2(2009); v.91:4-5(2009)

Online: 1949 to present (Full Text Delay: 6 months)

Website

http://hdl.handle.net/2429/29783

Author

Zou, Junxuan

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2010

Subject

Faculty of Medicine

Theses

Abstract

The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We examined the presence of ADAMTS in first trimester human placenta and only ADAMTS-12 was present in cultures of invasive extravillous cytotrophoblast (EVT) at significantly higher levels than in poorly invasive JEG-3 chorocarcinoma cells. Immunohistochemistry staining of chorionic villi derived from first trimester human placenta demonstrated that ADAMTS-12 was intensively immunolocalized in the cytotrophoblast layer but weakly immunolocalized in the poorly-invasive syncytial trophoblast layer.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/9760

Author

Ong, Aldrich Dixon

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1999

Subject

Faculty of Medicine

Theses

Abstract

Ovarian cancer is the most lethal gynecological cancer in the Western world, but comparatively little is known about its development. Epithelial ovarian carcinomas are thought to originate in the ovarian surface epithelium (OSE), i.e. the mesothelium covering the ovary, but experimental evidence for this origin has been lacking. Contrary to most epithelia where neoplastic progression is associated with loss of E-cadherin, this cell-cell adhesion molecule is sparse in normal human OSE but its expression increases in ovarian epithelial metaplasia and neoplasia.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/3482

Author

Ge, Hong

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1994

Subject

Faculty of Medicine

Theses

Abstract

This thesis investigated the expression and regulation of cytochrome P450s, aromatase (P450arom) and cholesterol side chain cleavage (P450scc) enzyme mRNAs in human granulosa-luteal cells using reverse transcription-polymerase chain reaction (RT-PCR). The two enzymes are instrumental in steroid hormone biosynthesis.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/30974

Author

Ota, Takayo

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2006

Subject

Faculty of Medicine

Theses

Abstract

Homeobox genes, which code for families of transcription factors, act at the top of genetic hierarchies. HOX genes specify positional identity during development, and in adult tissues, regulate differentiation and proliferation. Most ovarian carcinomas are derived from the ovarian surface epithelium (OSE). In contrast to other carcinomas, OSE differentiates further with neoplastic progression and acquires Mtillerian duct-derived epithelial properties. I tested the hypothesis that growth and differentiation in ovarian carcinogenesis are regulated by HOX genes.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/6315

Author

Chen, Victor

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1997

Subject

Faculty of Medicine

Theses

Abstract

There is increasing evidence to suggest that activin can function as an autocrine/paracrine regulator in various tissues, including the reproductive system. At the cellular level, activin acts via a family of activin receptor (ActR) subtypes which includes two type I (ActRI and ActRLB) and two type II (II and ILB) receptors. The role of activin in the human placenta is not clearly understood. In this study, the detection of inlubin/activin subunit and ActRI mRNA were examined in first trimester cytotrophoblasts, term cytotrophoblasts, extravillous trophoblast (EVT) cells, immortalized extravillous trophoblast (LEVT) cells, JEG-3 cells, decidual tissue, and decidual cells.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/30021

Author

Poon, Song Ling

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2010

Subject

Faculty of Medicine

Theses

Abstract

It is increasingly apparent that GnRH-II acts as an autocrine/paracrine regulator in non-pituitary tissues, in addition to its role in the regulation of gonadotropin synthesis, and is an important player in cancer cell biology. High levels of GnRH-II and GnRHR in malignant ovarian tumors as compared with benign ovarian tissues underlies the importance of understanding GnRH-II function in ovarian cancer. In an attempt to define the regulation of GnRH-II in these tissues, we found that a cyclic-AMP responsive element (CRE) is critical for GnRH-II promoter transcription.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/6811

Author

Vaananen, Jeffrey Eric

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1997

Subject

Faculty of Medicine

Theses

Abstract

These studies examined the effects of prostaglandin-F[sub 2a] (PGF[sub 2a]) on progesterone and 178-estradiol (estradiol) production, as well as DNA and PGF[sub 2a]-receptor (PGF[sub 2a]-R) mRNA levels, in the human granulosa-luteal cell (GLC). Additionally, the interactions of PGF[sub 2a] with human chorionic gonadotrophin (hCG), gonadotrophin-releasing hormone (GnRH) and prostaglandin E₂ (PGE₂) were examined, with respect to progesterone and estradiol production.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/10789

Author

Lee, Pearly S.N.

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1999

Subject

Faculty of Medicine

Theses

Abstract

It is well established that LH action is mediated primarily by adenylate cyclase/cAMP. Conversely, the role of inositol phosphate/calcium in LH signalling has only recently been investigated. We examined the effects of gonadotrophins on intracellular calcium mobilisation in HEK293 cells transiently transfected with human wild type or chimeric gonadotrophs receptors (n=3400). Intracellular free calcium concentration was measured using fura-2 microspectrofluorimetric techniques. Human LH (2-4 μg/ml) arid CG (10 IU/ml) consistently evoked oscillatory calcium signals in HEK293 cells transfected with hLHr, whereas hFSH (2-4 μg/ml) failed to elicit any calcium responses.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf