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8 records – page 1 of 1.

A Biological role for GnRH I and GnRH II at the maternal-fetal interface

https://cwslc.andornot.com/en/permalink/catalog113971
Zhou, Junshan. [Vancouver, BC?]: University of British Columbia , 2003.
Website
http://hdl.handle.net/2429/14957
Material Type
Thesis
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Thesis Shelf
Remodeling of the endometrial extracellular matrix, which occurs during the early stages of pregnancy in the human, is mediated by the temporal expression of urokinase-type plasminogen activator (uPA) and matrix metalloproteinases (MMP) in both the maternal and fetal compartments and counterbalance…
Website
http://hdl.handle.net/2429/14957
Author
Zhou, Junshan
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2003
Subject
Faculty of Medicine
Theses
Abstract
Remodeling of the endometrial extracellular matrix, which occurs during the early stages of pregnancy in the human, is mediated by the temporal expression of urokinase-type plasminogen activator (uPA) and matrix metalloproteinases (MMP) in both the maternal and fetal compartments and counterbalanced by their respective endogenous inhibitors, plasminogen activator inhibitor (PAI-1) and tissue inhibitors of metalloproteinases (TIMPs) in both an autocrine and paracrine manner. To date, the factors capable of regulating the expression of uPA and MMP proteolytic systems at the maternal-fetal interface remain poorly characterized.
Language
English
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The effects of the beta-adrenergic agonist, ritodrine, in the fetal lamb

https://cwslc.andornot.com/en/permalink/catalog114000
Van der Weyde, Marlene. [Vancouver, BC?]: University of British Columbia , 1990.
Website
http://hdl.handle.net/2429/30417
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Thesis
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Thesis Shelf
Ritodrine is a beta-adrenergic agonist commonly used to inhibit premature labor contractions in women. The primary goal of ritodrine tocolysis is to prolong gestation, however, other indications may include fetal distress. The purpose of the current study was to examine the metabolic and behavioral…
Website
http://hdl.handle.net/2429/30417
Author
Van der Weyde, Marlene
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1990
Subject
Faculty of Medicine
Theses
Abstract
Ritodrine is a beta-adrenergic agonist commonly used to inhibit premature labor contractions in women. The primary goal of ritodrine tocolysis is to prolong gestation, however, other indications may include fetal distress. The purpose of the current study was to examine the metabolic and behavioral effects of ritodrine in the fetus, using the chronically instrumented pregnant sheep as an experimental model. Ritodrine was infused continuously into 11 fetal lambs at a rate of 2.6 ug/minute for a period of 8, 12 or 24 hours. Samples were taken simultaneously at predetermined time periods from a fetal femoral artery, umbilical vein, maternal femoral artery and uterine vein for the analysis of fetal and maternal arterial and umbilical and uterine venous blood gases, acid-base status, hematocrit, ritodrine concentration, uterine and umbilical blood flow, and glucose, lactate and oxygen concentrations and fluxes.
Language
English
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Hindlimb blood flow and oxygen consumption in the late gestation fetal lamb

https://cwslc.andornot.com/en/permalink/catalog113991
Knight, Kathleen Elizaabeth. [Vancouver, BC?]: University of British Columbia , 1998.
Website
http://hdl.handle.net/2429/9896
Material Type
Thesis
Call Number
Thesis Shelf
The purpose of this research was to examine hindlimb blood flow and oxygen supply in the late-gestation fetal lamb under normal and pathophysiological conditions. Although the carcass, or non-visceral tissue, accounts for a large proportion of fetal weight and oxygen demand, it has received little …
Website
http://hdl.handle.net/2429/9896
Author
Knight, Kathleen Elizaabeth
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1998
Subject
Faculty of Medicine
Theses
Abstract
The purpose of this research was to examine hindlimb blood flow and oxygen supply in the late-gestation fetal lamb under normal and pathophysiological conditions. Although the carcass, or non-visceral tissue, accounts for a large proportion of fetal weight and oxygen demand, it has received little research attention. Because the hindlimb is composed of skin, bone, and skeletal muscle, it is representative of the carcass
Language
English
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Maternal leukocyte CD markers, apoptosis and band forms in preeclampsia

https://cwslc.andornot.com/en/permalink/catalog113970
Fuchisawa, Akiko. [Vancouver, BC?]: University of British Columbia , 2003.
Website
http://hdl.handle.net/2429/14664
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Thesis
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Preeclampsia is a pregnancy-specific condition, and it still remains one of the most common causes of maternal mortality in the developed world. Although the exact cause of preeclampsia has not been identified, it is most widely accepted that preeclampsia results from incomplete placentation. Inter…
Website
http://hdl.handle.net/2429/14664
Author
Fuchisawa, Akiko
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2003
Subject
Faculty of Medicine
Theses
Abstract
Preeclampsia is a pregnancy-specific condition, and it still remains one of the most common causes of maternal mortality in the developed world. Although the exact cause of preeclampsia has not been identified, it is most widely accepted that preeclampsia results from incomplete placentation. Interestingly, normotensive intrauterine growth restriction also shows the same defect of placentation. In preeclampsia, the maternal syndrome develops from a number of alternative pathways leading to uteroplacental mismatch and, consequently, the release of endothelium-activating factors. This research is focused on neutrophil activation and the hypothesis for this research was that maternal neutrophils and monocytes are inappropriately activated in preeclampsia but not in normotensive intrauterine growth restriction.
Language
English
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The maternal predisposition to the syndrome of pre-eclampsia

https://cwslc.andornot.com/en/permalink/catalog113968
Alasaly, Kadria A. [Vancouver, BC?]: University of British Columbia , 2004.
Website
http://hdl.handle.net/2429/15429
Material Type
Thesis
Call Number
Thesis Shelf
Pre-eclampsia, which is characterized by maternal hypertension, proteinuria, hypoperfusion of end organs and a systemic maternal innate inflammatory response, is a leading cause of maternal mortality and morbidity world-wide. When of early-onset, pre-eclampsia is associated with fetal intrauterine …
Website
http://hdl.handle.net/2429/15429
Author
Alasaly, Kadria A.
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2004
Subject
Faculty of Medicine
Theses
Abstract
Pre-eclampsia, which is characterized by maternal hypertension, proteinuria, hypoperfusion of end organs and a systemic maternal innate inflammatory response, is a leading cause of maternal mortality and morbidity world-wide. When of early-onset, pre-eclampsia is associated with fetal intrauterine growth restriction (IUGR). IUGR can occur in isolation, so-called normotensive IUGR. What is poorly understood is that some women develop the maternal syndrome of pre-eclampsia whilst others have only the fetal syndrome (normotensive IUGR), despite the fact that the initiating event in both is believed to be reduced uteroplacental perfusion.
Language
English
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Maternal progesterone and fetal cortisol responses to hypoxemia in pregnant sheep

https://cwslc.andornot.com/en/permalink/catalog113981
Wu, Li-Hua. [Vancouver, BC?]: University of British Columbia , 1996.
Website
http://hdl.handle.net/2429/4269
Material Type
Thesis
Call Number
Thesis Shelf
The placenta is an important endocrine organ producing large amounts of steroid and protein hormones which are released into the maternal and fetal circulations. Moreover, it has a very high metabolic rate and consumes a significant proportion of the oxygen and glucose delivered to the uterus and i…
Website
http://hdl.handle.net/2429/4269
Author
Wu, Li-Hua
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1996
Subject
Faculty of Medicine
Theses
Abstract
The placenta is an important endocrine organ producing large amounts of steroid and protein hormones which are released into the maternal and fetal circulations. Moreover, it has a very high metabolic rate and consumes a significant proportion of the oxygen and glucose delivered to the uterus and its contents. However, while there have been many studies on the effects of hypoxemia on fetal cardiovascular, metabolic and endocrine functions, there are limited data on the effects of reduced oxygenation on placental endocrine activities. In the present study, we examined the effects of acute (2-h) moderate (maternal Pao₂ lowered by 27-35%, n=5) and severe (maternal Pao₂ lowered by 41-58%, n=4) hypoxemia on placental progesterone output into the maternal circulation in 7 chronically instrumented pregnant sheep (125 to 136 d). Hypoxemia was achieved by lowering maternal inspired O₂ concentration and the hypoxemia period was preceded and followed by 2 h pre-hypoxia and recovery periods, respectively. Control experiments (n=4), involving 6 h periods of normoxia were also carried out.
Language
English
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The prediction of adverse maternal outcomes in pre-eclampsia

https://cwslc.andornot.com/en/permalink/catalog113966
Devarakonda, Rajashree M. [Vancouver, BC?]: University of British Columbia , 2005.
Website
http://hdl.handle.net/2429/16403
Material Type
Thesis
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Thesis Shelf
Pre-eclampsia (PET) continues to contribute to maternal and perinatal morbidity and mortality. Management decisions include an evaluation of maternal risk, which is assisted by expert opinion-based guidelines, while not accounting for gestational age (GA) at diagnosis. We evaluated the feasibility …
Website
http://hdl.handle.net/2429/16403
Author
Devarakonda, Rajashree M.
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2005
Subject
Faculty of Medicine
Theses
Abstract
Pre-eclampsia (PET) continues to contribute to maternal and perinatal morbidity and mortality. Management decisions include an evaluation of maternal risk, which is assisted by expert opinion-based guidelines, while not accounting for gestational age (GA) at diagnosis. We evaluated the feasibility of developing a severity score that can predict adverse maternal outcome.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
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Regulated expression of aggrecanases of ADAMTS family in endometrial physiology and pathology

https://cwslc.andornot.com/en/permalink/catalog113954
Wen, Jiadi. [Vancouver, BC?]: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/30478
Material Type
Thesis
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Thesis Shelf
The ADAMTS (A Disintegrin and Metalloproteinase with TromboSpondin Repeats) are a novel family of secreted metalloproteinases. There is increasing evidence that distinct ADAMTS subtypes play key roles in embryonic development, reproduction and cancer. Nineteen ADAMTS subtypes have been identified i…
Website
http://hdl.handle.net/2429/30478
Author
Wen, Jiadi
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
The ADAMTS (A Disintegrin and Metalloproteinase with TromboSpondin Repeats) are a novel family of secreted metalloproteinases. There is increasing evidence that distinct ADAMTS subtypes play key roles in embryonic development, reproduction and cancer. Nineteen ADAMTS subtypes have been identified in humans but most of them have been characterized only at the structural level. ADAMTS-1, -4, -5, -8, -9 and -15 have been subclassified into a subfamily, known as aggrecanases, owing to their ability to cleave the important extracellular matrix components, versican and aggrecan.
Language
English
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8 records – page 1 of 1.