Website

http://hdl.handle.net/2429/29313

Author

Wang, Jian

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1989

Subject

Faculty of Medicine

Theses

Abstract

The present study was conducted to investigate the hypothesis that membrane phosphoinositide breakdown may participate in the actions of luteinizing hormone-releasing hormone (LHRH) on hormone production in the rat ovary. In granulosa cells prelabeled with [³H]-arachidonic acid or [³H]-inositol, treatment with LHRH increased the accumulation of radiolabeled inositol lipids, diacylglycerol and free arachidonic acid, but luteinizing hormone (LH) or cholera toxin did not exert the same effect. Activation of protein kinase C by the phorbol ester, 12-0-tetradecanoyl phorbol-13-acetate (TPA) had a stimulatory action on membrane phosphoinositide breakdown.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/28961

Author

Shi, Fengtao

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2010

Subject

Faculty of Medicine

Theses

Abstract

Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regulator of ovarian function, but its overall effects, particularly relating to activin A actions, are unknown. We examined the potential crosstalk between activin A and GDF9 in primary cultures of human granulosa-lutein (hGL) cells. Pretreatment of hGL cells with GDF9 for 24 h resulted in an increased expression of activin receptors and Smad2/3, and decreased inhibitory Smad7 activity. These effects were attenuated by BMP type II receptor ectodomain (BMPR2 ECD), a GDF9 antagonist.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://www.longwoods.com/home.php?cat=571

Website Notes

To read individual chapters online...click on the link above

Author

Baker, G. Ross

MacIntosh-Murray, Anu

Porcellato, Christina

Dionne, Lynn

Stelmacovich, Kim

Born, Karen

Place of Publication

[Toronto, ON]

Publisher

Longwoods Publishing Corporation

Publication Date

2008

Physical Description

Paperback: 292 pages.

Subject

Health Care Delivery Systems

Hospitals Services

Abstract

An examination of leadership strategies, organizational processes and investments made to create and sustain improvement in healthcare.

ISBN

9780981008905

Language

English

Material Type

Book

Call Number

REF JB 100 BAK 2008

Copies

Website

http://www.nap.edu/catalog.php?record_id=11903

Website Notes

Read online or download as PDF.

Author

Olsen, LeighAnne;

Aisner, Dara;

McGinnis, J. Michael (Eds).

Place of Publication

Washington, DC

Publisher

National Academies Press

Publication Date

2007

Physical Description

374 pages, 2 MB PDF file.

Subject

Health Care Delivery Systems

Evidence-Based Medicine

Abstract

This book considers how health care is structured to develop and to apply evidence--from health profession training and infrastructure development to advances in research methodology, patient engagement, payment schemes, and measurement--and highlights opportunities for the creation of a sustainable learning health care system that gets the right care to people when they need it and then captures the results for improvement. This book will be of primary interest to hospital and insurance industry administrators, health care providers, those who train and educate health workers, researchers, and policymakers.

ISBN

978-0-309-10300-8

Language

English

Material Type

Online