Website

http://hdl.handle.net/2429/29313

Author

Wang, Jian

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1989

Subject

Faculty of Medicine

Theses

Abstract

The present study was conducted to investigate the hypothesis that membrane phosphoinositide breakdown may participate in the actions of luteinizing hormone-releasing hormone (LHRH) on hormone production in the rat ovary. In granulosa cells prelabeled with [³H]-arachidonic acid or [³H]-inositol, treatment with LHRH increased the accumulation of radiolabeled inositol lipids, diacylglycerol and free arachidonic acid, but luteinizing hormone (LH) or cholera toxin did not exert the same effect. Activation of protein kinase C by the phorbol ester, 12-0-tetradecanoyl phorbol-13-acetate (TPA) had a stimulatory action on membrane phosphoinositide breakdown.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/28961

Author

Shi, Fengtao

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2010

Subject

Faculty of Medicine

Theses

Abstract

Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regulator of ovarian function, but its overall effects, particularly relating to activin A actions, are unknown. We examined the potential crosstalk between activin A and GDF9 in primary cultures of human granulosa-lutein (hGL) cells. Pretreatment of hGL cells with GDF9 for 24 h resulted in an increased expression of activin receptors and Smad2/3, and decreased inhibitory Smad7 activity. These effects were attenuated by BMP type II receptor ectodomain (BMPR2 ECD), a GDF9 antagonist.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Place of Publication

[Vancouver, BC?]

Publisher

The British Columbia Centre for Disease Control

Publication Date

2006

Physical Description

1 DVD (33 mins.)

Subject

Influenza

Viral Diseases

Abstract

This DVD brings together experts from across Canada to provide basic information about influenza and to discuss the threat of a pandemic and how we can all work together to prepare. Using 3D animation and news coverage of a simulated pandemic the video paints a realistic portrayal of what to expect and is based on the six essential elements of pandemic preparedness planning including: surveillance and monitoring, antivirals, communications, emergency management and coordination, clinical health services and vaccines.

Language

English

Material Type

Video

Call Number

REF FG 340 PAN 2006

Copies

Publisher

ThedaCare Center for Healthcare Value

Publication Date

2011

Physical Description

DVD

Subject

Lean Leader Development

Abstract

In this DVD, you will see ThedaCare's leading lean practices at their system-level boardroom (the "visual room") and at multiple locations throughout Appleton Medical Center. You will hear directly from the leading figures in the development of the ThedaCare Improvement System: Dr. John Toussaint, CEO of the ThedaCare Center for Healthcare Value, and Dr. Dean Gruner, CEO of ThedaCare. You will also see and hear other leaders, from the hospital COO to a unit-level nursing manager, describe how strategy deployment creates alignment throughout the organization.

The DVD illustrates how ThedaCare's "true north" objectives are translated to multiple departments. You will also see how leaders use standardized visual boards to track key metrics, rapid improvement events, and staff suggestions - all aimed at providing the best patient care.

Language

English

Material Type

Video

Call Number

REF AA 120 THE 2011

Copies