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20 records – page 1 of 1.

Chromosome segregation and meiotic defects in carriers of chromosomal abnormalities

https://cwslc.andornot.com/en/permalink/catalog113956
Kirkpatrick, Gordon. [Vancouver, BC?]: University of British Columbia , 2009.
Website
http://hdl.handle.net/2429/9705
Material Type
Thesis
Call Number
Thesis Shelf
Male carriers of chromosomal abnormalities (CA) are more frequent in the infertile population. These men have higher levels of sperm aneuploidy due to the aberrant segregation of the chromosomes involved in the abnormality. The presence of a CA may also influence the segregation of other chromosome…
Website
http://hdl.handle.net/2429/9705
Author
Kirkpatrick, Gordon
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2009
Subject
Faculty of Medicine
Theses
Abstract
Male carriers of chromosomal abnormalities (CA) are more frequent in the infertile population. These men have higher levels of sperm aneuploidy due to the aberrant segregation of the chromosomes involved in the abnormality. The presence of a CA may also influence the segregation of other chromosomes, in a process known as in interchromosomal effect (ICE). The behaviour of the CA during meiosis may account for the infertility observed in this population. We studied chromosome segregation, ICE and meiotic defects in a variety of CA. In carriers of CA, we determined the segregation patterns of chromosomes involved in the abnormality.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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The art of evaluation: A resource for educators and trainers

https://cwslc.andornot.com/en/permalink/catalog112041
Fenwick, Tara J., Parsons, Jim. [Toronto, ON]: Thompson Educational Publishing, Inc. , 2009. 2nd ed.
Material Type
Book
Call Number
REF AA 400 FEN 2009
Availability
7 copies, 7 available
This book is a practical introduction to learner evaluation in the various contexts of adult education. The authors highlight and review the principles of evaluation, and provide strategies on how to implement evaluation in different learning situations. This book is a resource for educators, train…
Author
Fenwick, Tara J.
Parsons, Jim
Edition
2nd ed.
Place of Publication
[Toronto, ON]
Publisher
Thompson Educational Publishing, Inc.
Publication Date
2009
Physical Description
Softcover: 274 pp.
Subject
Leadership/Coaching
Program Evaluation
Abstract
This book is a practical introduction to learner evaluation in the various contexts of adult education. The authors highlight and review the principles of evaluation, and provide strategies on how to implement evaluation in different learning situations. This book is a resource for educators, trainers and others concerned about the critical role of evaluation in the learning process.
Notes
RESTRICTED TO PHSA LEADERSHIP COACHING PARTICIPANTS ONLY.
ISBN
978-1-55077-166-4
Language
English
Material Type
Book
Call Number
REF AA 400 FEN 2009

Copies

Copy 4 BC Children's and Women's Study and Learning Commons REF Available
Copy 3 BC Children's and Women's Study and Learning Commons REF Available
Copy 2 BC Children's and Women's Study and Learning Commons REF Available
Copy 1 BC Children's and Women's Study and Learning Commons REF Available
Copy 7 BC Children's and Women's Study and Learning Commons REF Available
Copy 6 BC Children's and Women's Study and Learning Commons REF Available
Copy 5 BC Children's and Women's Study and Learning Commons REF Available
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The PIERS (Pre-eclampsia Integrated Estimate of RiSk) model : development of a valid outcome prediction model for pre-eclampsia.

https://cwslc.andornot.com/en/permalink/catalog113957
Menzies, Jennifer Marie. [Vancouver, BC?]: University of British Columbia , 2009.
Website
http://hdl.handle.net/2429/6844
Material Type
Thesis
Call Number
Thesis Shelf
Availability
1 copy, 1 available
This research responded to the need to define evidence-based criteria of maternal risk by developing a model - the Pre-eclampsia Integrated Estimate of RiSk (or PIERS) model ? that predicts a combined adverse maternal outcome (mortality and/or significant morbidities) within 48 hour of, and up to s…
Website
http://hdl.handle.net/2429/6844
Author
Menzies, Jennifer Marie
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2009
Subject
Faculty of Medicine
Theses
Abstract
This research responded to the need to define evidence-based criteria of maternal risk by developing a model - the Pre-eclampsia Integrated Estimate of RiSk (or PIERS) model ? that predicts a combined adverse maternal outcome (mortality and/or significant morbidities) within 48 hour of, and up to seven days after, admission with pre-eclampsia (study eligibility)
Language
English
Material Type
Thesis
Call Number
Thesis Shelf

Copies

Copy 1 BC Children's and Women's Study and Learning Commons Thesis Shelf Available
Websites
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Infusion Nursing:: An Evidence-Based Approach

https://cwslc.andornot.com/en/permalink/catalog125213
McGee, Steven R.;. Philadelphia: Elsevier , 2009. 3rd.
Material Type
Book
Call Number
REF WB 200 ALE 2009
Availability
1 copy, 1 available
With a new focus on evidence-based practice, the 3rd edition of this authoritative reference covers every aspect of infusion therapy and can be applied to any clinical setting. Completely updated content brings you the latest advances in equipment, technology, best practices, guidelines, and patien…
Author
McGee, Steven R.;
Edition
3rd
Place of Publication
Philadelphia
Publisher
Elsevier
Publication Date
2009
Physical Description
624 pp Hardcover
Subjects
Evidence-Based Medicine
Infusion nursing
Evidence Based
Abstract
With a new focus on evidence-based practice, the 3rd edition of this authoritative reference covers every aspect of infusion therapy and can be applied to any clinical setting. Completely updated content brings you the latest advances in equipment, technology, best practices, guidelines, and patient safety. Other key topics include quality management, ethical and legal issues, patient education, and financial considerations. Ideal as a practical clinical reference, this essential guide is also a perfect review tool for the CRNI examination.
ISBN
978-1416064107
Material Type
Book
Call Number
REF WB 200 ALE 2009

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
Images
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Clinical and endocrine responses to ovarian hyperstimulation in flare and and luteal gonadotropin-releasing hormone agonist (GnRHa) protocols

https://cwslc.andornot.com/en/permalink/catalog113958
Nguyen, Tuan-Anh T. [Vancouver, BC?]: University of British Columbia , 2008.
Website
http://hdl.handle.net/2429/1395
Material Type
Thesis
Call Number
Thesis Shelf
Due to the ?flare effect? associated with the flare protocol, variation in the degree of follicular maturation during stimulation may result in differences in follicle response as compared to the luteal protocol which is based on maximal pituitary suppression and synchronization of follicular matur…
Website
http://hdl.handle.net/2429/1395
Author
Nguyen, Tuan-Anh T
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2008
Subject
Faculty of Medicine
Theses
Abstract
Due to the ?flare effect? associated with the flare protocol, variation in the degree of follicular maturation during stimulation may result in differences in follicle response as compared to the luteal protocol which is based on maximal pituitary suppression and synchronization of follicular maturation. In this study, besides other methods, Anti-Mullerian Hormone (AMH), a novel marker for ovarian reserve, was used as a tool to evaluate the ovarian responsiveness to stimulation.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Aneuploidy and DNA fragmentation in morphologically abnormal sperm

https://cwslc.andornot.com/en/permalink/catalog113959
Tang, Steven Siu Yan. [Vancouver, BC?]: University of British Columbia , 2008.
Website
http://hdl.handle.net/2429/945
Material Type
Thesis
Call Number
Thesis Shelf
Intracytoplasmic sperm injection (ICSI) has been a successful assisted reproductive technique for men with severe male-factor infertility. However, ICSI requires the subjective selection of normal looking sperm, which does not preclude the transmission of genetically abnormal sperm. Correlation bet…
Website
http://hdl.handle.net/2429/945
Author
Tang, Steven Siu Yan
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2008
Subject
Faculty of Medicine
Theses
Abstract
Intracytoplasmic sperm injection (ICSI) has been a successful assisted reproductive technique for men with severe male-factor infertility. However, ICSI requires the subjective selection of normal looking sperm, which does not preclude the transmission of genetically abnormal sperm. Correlation between abnormal sperm morphology and chromosomal abnormalities has been suggested but not been conclusive and less is known about the connection between sperm morphology and DNA integrity. Sperm morphology will be evaluated on its ability to identify the level of chromosomal abnormalities or fragmented DNA in sperm. To further focus this investigation on sperm morphology, men with infertility isolated to abnormal sperm morphology (isolated teratozoopsermia) are examined.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Meiotic defects in infertile men

https://cwslc.andornot.com/en/permalink/catalog113960
Ferguson, Kyle Akira. [Vancouver, BC?]: University of British Columbia , 2008.
Website
http://hdl.handle.net/2429/1228
Material Type
Thesis
Call Number
Thesis Shelf
While the introduction of intracytoplasmic sperm injection (ICSI) has revolutionized the treatment of male infertility, concerns have been raised regarding the risk of chromosomal abnormalities in pregnancies derived from ICSI. Studies on sperm from infertile men have suggested that this population…
Website
http://hdl.handle.net/2429/1228
Author
Ferguson, Kyle Akira
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2008
Subject
Faculty of Medicine
Theses
Abstract
While the introduction of intracytoplasmic sperm injection (ICSI) has revolutionized the treatment of male infertility, concerns have been raised regarding the risk of chromosomal abnormalities in pregnancies derived from ICSI. Studies on sperm from infertile men have suggested that this population may produce higher rates of aneuploid sperm. Thus, we hypothesized that defects in early meiotic events may contribute to both male infertility and the production of aneuploid sperm.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Learning healthcare system: Workshop summary (IOM Roundtable on Evidence-Based Medicine)

https://cwslc.andornot.com/en/permalink/catalog113231
Olsen, LeighAnne;, Aisner, Dara;, McGinnis, J. Michael (Eds). Washington, DC: National Academies Press , 2007.
Website
http://www.nap.edu/catalog.php?record_id=11903
Material Type
Online
This book considers how health care is structured to develop and to apply evidence--from health profession training and infrastructure development to advances in research methodology, patient engagement, payment schemes, and measurement--and highlights opportunities for the creation of a sustainabl…
Website
http://www.nap.edu/catalog.php?record_id=11903
Website Notes
Read online or download as PDF.
Author
Olsen, LeighAnne;
Aisner, Dara;
McGinnis, J. Michael (Eds).
Place of Publication
Washington, DC
Publisher
National Academies Press
Publication Date
2007
Physical Description
374 pages, 2 MB PDF file.
Subject
Health Care Delivery Systems
Evidence-Based Medicine
Abstract
This book considers how health care is structured to develop and to apply evidence--from health profession training and infrastructure development to advances in research methodology, patient engagement, payment schemes, and measurement--and highlights opportunities for the creation of a sustainable learning health care system that gets the right care to people when they need it and then captures the results for improvement. This book will be of primary interest to hospital and insurance industry administrators, health care providers, those who train and educate health workers, researchers, and policymakers.
ISBN
978-0-309-10300-8
Language
English
Material Type
Online
Websites
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Roles of Confined Placental Mosaicism (CPM) and H19/IGF2 imprinting in pregnancies derived from intracytoplasmic sperm injection (ICSI)

https://cwslc.andornot.com/en/permalink/catalog113961
Hatakeyama, Chiho. [Vancouver, BC?]: University of British Columbia , 2007.
Website
http://hdl.handle.net/2429/32719
Material Type
Thesis
Call Number
Thesis Shelf
In contrast to the success of ICSI in treating male infertility, concerns have been raised about the health outcomes of the children conceived through this procedure. Cohort studies have shown that the ICSI population has an increase in low birth weight (LBW), birth defects, chromosomal abnormaliti…
Website
http://hdl.handle.net/2429/32719
Author
Hatakeyama, Chiho
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2007
Subject
Faculty of Medicine
Theses
Abstract
In contrast to the success of ICSI in treating male infertility, concerns have been raised about the health outcomes of the children conceived through this procedure. Cohort studies have shown that the ICSI population has an increase in low birth weight (LBW), birth defects, chromosomal abnormalities, and imprinting disorders. However, the underlying causes remain unknown.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Recombinant human activated protein C as a therapy for pre-eclampsia

https://cwslc.andornot.com/en/permalink/catalog113962
Peng, Gang. [Vancouver, BC?]: University of British Columbia , 2007.
Website
http://hdl.handle.net/2429/32051
Material Type
Thesis
Call Number
Thesis Shelf
Pre-eclampsia remains one of the most common causes of maternal mortality in the developed world, and we still have no known effective prophylaxis and proven modifiers. The recent successful clinical trial of recombinant human activated protein C (rhAPC) in the management of SIRS (systemic inflamma…
Website
http://hdl.handle.net/2429/32051
Author
Peng, Gang
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2007
Subject
Faculty of Medicine
Theses
Abstract
Pre-eclampsia remains one of the most common causes of maternal mortality in the developed world, and we still have no known effective prophylaxis and proven modifiers. The recent successful clinical trial of recombinant human activated protein C (rhAPC) in the management of SIRS (systemic inflammatory response syndrome) has drawn attention to the possible use of this medicine for other conditions. Pre-eclampsia, has remarkable similarity to SIRS and may be such a condition.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Art and science of coaching: Inner dynamics of coaching

https://cwslc.andornot.com/en/permalink/catalog113847
Atkinson, Marilyn, Chois, Rae. Exalon Publishing , 2007.
Material Type
Book
Call Number
REF AA 75 ATK 2007
Availability
1 copy, 1 available
Outside of religious and political movements there is one major human development in the world today- coaching.
Author
Atkinson, Marilyn
Chois, Rae
Publisher
Exalon Publishing
Publication Date
2007
Physical Description
Softcover, 238 p.
Series
Art & Science of Coaching
Subject
Leadership/Coaching
Abstract
Outside of religious and political movements there is one major human development in the world today- coaching.
ISBN
9780978370442
Language
English
Material Type
Book
Call Number
REF AA 75 ATK 2007

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Art and science of coaching: Step-by-step coaching

https://cwslc.andornot.com/en/permalink/catalog113869
Atkinson, Marilyn, Chois, Rae. Exalon Publishing , 2007.
Material Type
Book
Call Number
REF AA 75 ATK 2007b
Availability
1 copy, 1 available
Author
Atkinson, Marilyn
Chois, Rae
Publisher
Exalon Publishing
Publication Date
2007
Physical Description
Softcover, 251 p.
Series
Art & Science of Coaching
Subject
Leadership/Coaching
ISBN
9780978370459
Language
English
Material Type
Book
Call Number
REF AA 75 ATK 2007b

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Textbook of Pediatric Emergency Procedures

https://cwslc.andornot.com/en/permalink/catalog125197
King, Christopher, Henretig, Fred, King, Brent, Loiselle, John. Philadelphia, PA: Wolters Kluwer , 2007. 2nd.
Material Type
Book
Call Number
REF EB 800 KIN 2007
Availability
1 copy, 1 available
Widely acclaimed for its outstanding step-by-step illustrations, comprehensive coverage, and reader-friendly format, Textbook of Pediatric Emergency Procedures is now in its thoroughly updated Second Edition. In 137 chapters, the book provides clear, complete instructions on every emergency medicin…
Author
King, Christopher
Henretig, Fred
King, Brent
Loiselle, John
Edition
2nd
Place of Publication
Philadelphia, PA
Publisher
Wolters Kluwer
Publication Date
2007
Physical Description
Hardcover, 1344 pp
Subjects
Pediatrics
Emergency Procedures
Subject
Emergency Medicine
Leadership/Coaching
Abstract
Widely acclaimed for its outstanding step-by-step illustrations, comprehensive coverage, and reader-friendly format, Textbook of Pediatric Emergency Procedures is now in its thoroughly updated Second Edition. In 137 chapters, the book provides clear, complete instructions on every emergency medicine procedure performed on infants, children, and adolescents. More than 1,000 detailed drawings, most in two-color, show howto perform each procedure. This edition includes a new chapter on new technologies and techniques for managing the difficult airway. Other new topics include use of tissue adhesives in laceration repair, focused abdominal sonography for trauma (FAST), management of priapism, reimplanting an avulsed permanent tooth, use of automatic external defibrillators, and procedures related to bioterrorism.
ISBN
978-0781753869
Language
English
Material Type
Book
Call Number
REF EB 800 KIN 2007

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Expression and function of HOXA genes in the normal ovary and ovarian carcinoma

https://cwslc.andornot.com/en/permalink/catalog113963
Ota, Takayo. [Vancouver, BC?]: University of British Columbia , 2006.
Website
http://hdl.handle.net/2429/30974
Material Type
Thesis
Call Number
Thesis Shelf
Homeobox genes, which code for families of transcription factors, act at the top of genetic hierarchies. HOX genes specify positional identity during development, and in adult tissues, regulate differentiation and proliferation. Most ovarian carcinomas are derived from the ovarian surface epitheliu…
Website
http://hdl.handle.net/2429/30974
Author
Ota, Takayo
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2006
Subject
Faculty of Medicine
Theses
Abstract
Homeobox genes, which code for families of transcription factors, act at the top of genetic hierarchies. HOX genes specify positional identity during development, and in adult tissues, regulate differentiation and proliferation. Most ovarian carcinomas are derived from the ovarian surface epithelium (OSE). In contrast to other carcinomas, OSE differentiates further with neoplastic progression and acquires Mtillerian duct-derived epithelial properties. I tested the hypothesis that growth and differentiation in ovarian carcinogenesis are regulated by HOX genes.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Implications of BRCA-loss phenotype in epithelial ovarian carcinoma

https://cwslc.andornot.com/en/permalink/catalog113964
Press, Joshua Zephyr. [Vancouver, BC?]: University of British Columbia , 2006.
Website
http://hdl.handle.net/2429/32234
Material Type
Thesis
Call Number
Thesis Shelf
Loss of BRCA1/BRCA2 function through genetic or epigenetic mechanisms is common in epithelial ovarian carcinomas (EOC), but because there are multiple potential mechanisms of loss, the overall frequency is unknown. We characterized loss of BRCA1/BRCA2 at the DNA, RNA and protein level from an unsel…
Website
http://hdl.handle.net/2429/32234
Author
Press, Joshua Zephyr
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2006
Subject
Faculty of Medicine
Theses
Abstract
Loss of BRCA1/BRCA2 function through genetic or epigenetic mechanisms is common in epithelial ovarian carcinomas (EOC), but because there are multiple potential mechanisms of loss, the overall frequency is unknown. We characterized loss of BRCA1/BRCA2 at the DNA, RNA and protein level from an unselected, consecutive series 49 non-mucinous, invasive EOC. BRCAl-loss was found in 21/49 tumors (43%).
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Gonadotropins and leptin : the role and molecular mechanism in normal and neoplastic ovarian epithelium cells

https://cwslc.andornot.com/en/permalink/catalog113965
Choi, Jung-Hye. [Vancouver, BC?]: University of British Columbia , 2006.
Website
http://hdl.handle.net/2429/18509
Material Type
Thesis
Call Number
Thesis Shelf
Ovarian cancer is the sixth most common cancer and the fifth leading cause of cancer-related death among women in developed countries. There is increasing evidence suggesting that the hormonal environment of the normal ovarian surface epithelium (OSE) and ovarian epithelial cancer (OEC) cells is as…
Website
http://hdl.handle.net/2429/18509
Author
Choi, Jung-Hye
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2006
Subject
Faculty of Medicine
Theses
Abstract
Ovarian cancer is the sixth most common cancer and the fifth leading cause of cancer-related death among women in developed countries. There is increasing evidence suggesting that the hormonal environment of the normal ovarian surface epithelium (OSE) and ovarian epithelial cancer (OEC) cells is associated with the development and progression of ovarian cancer. Exposure to excess gonadotropins and leptin, related to menopause or infertility therapy and obesity, respectively, has been implicated as a risk factor for ovarian cancer.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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One: The art and practice of conscious leadership

https://cwslc.andornot.com/en/permalink/catalog112446
Secretan, Lance. Caledon, ON: The Secretan Center Inc. , 2006.
Material Type
Book
Call Number
REF AA 75 SEC 2006
Availability
1 copy, 1 available
Leadership theory utilizing the CASTLE principles. CASTLE is an acronym for six attributes: Courage, Authenticity, Service, Truthfulness, Love, and Effectiveness. The successful application of the CASTLE Principles can lead to personal growth and improved organizational performance. This book also …
Author
Secretan, Lance
Place of Publication
Caledon, ON
Publisher
The Secretan Center Inc.
Publication Date
2006
Physical Description
Hardcover: 201 p.
Subject
Leadership/Coaching
Abstract
Leadership theory utilizing the CASTLE principles. CASTLE is an acronym for six attributes: Courage, Authenticity, Service, Truthfulness, Love, and Effectiveness. The successful application of the CASTLE Principles can lead to personal growth and improved organizational performance. This book also combines many practical exercises and reflections to help refresh ideas about leadership and life.
Language
English
Material Type
Book
Call Number
REF AA 75 SEC 2006

Copies

Copy 1 BC Children's and Women's Study and Learning Commons Available
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Fifth discipline: The art and practice of the learning organization

https://cwslc.andornot.com/en/permalink/catalog113890
Senge, Peter M. New York: Doubleday , 2006. Rev. ed.
Material Type
Book
Call Number
REF AA 500 SEN 2006
Availability
2 copies, 2 available
The Fifth Discipline, is based on fifteen years of experience in putting the book's ideas into practice. As Senge makes clear, in the long run the only sustainable competitive advantage is your organization's ability to learn faster than the competition. The leadership stories in the book demonstra…
Author
Senge, Peter M.
Edition
Rev. ed.
Place of Publication
New York
Publisher
Doubleday
Publication Date
2006
Physical Description
Softcover, 445 p.
Subject
Management
Efficiency
Abstract
The Fifth Discipline, is based on fifteen years of experience in putting the book's ideas into practice. As Senge makes clear, in the long run the only sustainable competitive advantage is your organization's ability to learn faster than the competition. The leadership stories in the book demonstrate the many ways that the core ideas in The Fifth Discipline, many of which seemed radical when first published in 1990, have become deeply integrated into people's ways of seeing the world and their managerial practices.
ISBN
9780385517256
Language
English
Material Type
Book
Call Number
REF AA 500 SEN 2006

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
Copy 2 BC Children's and Women's Study and Learning Commons REF Available
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The prediction of adverse maternal outcomes in pre-eclampsia

https://cwslc.andornot.com/en/permalink/catalog113966
Devarakonda, Rajashree M. [Vancouver, BC?]: University of British Columbia , 2005.
Website
http://hdl.handle.net/2429/16403
Material Type
Thesis
Call Number
Thesis Shelf
Pre-eclampsia (PET) continues to contribute to maternal and perinatal morbidity and mortality. Management decisions include an evaluation of maternal risk, which is assisted by expert opinion-based guidelines, while not accounting for gestational age (GA) at diagnosis. We evaluated the feasibility …
Website
http://hdl.handle.net/2429/16403
Author
Devarakonda, Rajashree M.
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2005
Subject
Faculty of Medicine
Theses
Abstract
Pre-eclampsia (PET) continues to contribute to maternal and perinatal morbidity and mortality. Management decisions include an evaluation of maternal risk, which is assisted by expert opinion-based guidelines, while not accounting for gestational age (GA) at diagnosis. We evaluated the feasibility of developing a severity score that can predict adverse maternal outcome.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Physical and functional interaction of p53 and p110a and implications in ovarian carcinogenesis

https://cwslc.andornot.com/en/permalink/catalog113967
Astanehe, Arezoo. [Vancouver, BC?]: University of British Columbia , 2005.
Website
http://hdl.handle.net/2429/16421
Material Type
Thesis
Call Number
Thesis Shelf
n approximately 40% of ovarian cancers, PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) is amplified. This amplification correlates with increased PIK3CA transcription, p110α protein expression, and PI3K activity. Moreover, PIK3CA is implicated as…
Website
http://hdl.handle.net/2429/16421
Author
Astanehe, Arezoo
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2005
Subject
Faculty of Medicine
Theses
Abstract
n approximately 40% of ovarian cancers, PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) is amplified. This amplification correlates with increased PIK3CA transcription, p110α protein expression, and PI3K activity. Moreover, PIK3CA is implicated as an oncogene in ovarian cancers. Another common mutation in ovarian cancer leads to loss of p53 function. Alterations to p53 are known to be involved in tumour development and progression.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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