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Knowledge Translation in Nursing and Healthcare provides authoritative guidance on the implementation of evidence-informed practice, covering issue identification and clarification, solution building and implementation, evaluation, and sustainment. Integrating theory, empirical research, and experi…
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Learn to confidently manage the growing number of stroke rehabilitation clients with Gillen'sStroke Rehabilitation: A Function-Based Approach, 5th Edition . Using a holistic and multidisciplinary approach, this unique text remains theonlycomprehensive, evidence-based stroke rehabilitation resource …
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The leading text in pediatric nursing, Wong's Nursing Care of Infants and Children takes a unique, easy-to-understand developmental approach to describe the care of children at each age and stage of development. Childhood diseases and disorders are organized by age groups and body systems, and desc…
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This expanded second edition of Canadian Perspectives on Advanced Practice Nursing uses a case-study approach to understanding advanced practice nursing roles and competencies and their impact across all levels of the health care system. Focusing on the roles of clinical nurse specialists and nurse…
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This book examines how expert critical care nurses use scientific knowledge, professional experience, and a careful attention to each patient's changing condition to provide excellent nursing care. Based on descriptive interviews and observational studies of 205 nurses, it helps readers at all leve…
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One of the world's most widely read gynecology texts for nearly 50 years,Speroff 's Clinical Gynecologic Endocrinology and Infertilityprovides a complete explanation of the female endocrine system and offers practical guidance for evaluation and treatment of common disorders. In this fully revised …
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The Neonatal Resuscitation Program (NRP) is an educational program jointly sponsored with the American Heart Association (AHA). The course conveys an evidence-based approach to care of the newborn at birth and facilitates effective team-based care for healthcare professionals who care for newborns …
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Teaching is one of the most valuable services nurses provide to patients and families. But whether in the hospital, clinic, home, or long-term care facility, other tasks and responsibilities often compete for nurses' time. This book offers nurses useful, everyday information to apply to real-life …
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Ovarian cancer is the most lethal gynecological cancer in the Western world, but comparatively little is known about its development. Epithelial ovarian carcinomas are thought to originate in the ovarian surface epithelium (OSE), i.e. the mesothelium covering the ovary, but experimental evidence fo…
These studies examined the effects of prostaglandin-F[sub 2a] (PGF[sub 2a]) on progesterone and 178-estradiol (estradiol) production, as well as DNA and PGF[sub 2a]-receptor (PGF[sub 2a]-R) mRNA levels, in the human granulosa-luteal cell (GLC). Additionally, the interactions of PGF[sub 2a] with hum…
The studies undertaken herewithin sought to characterize the pattern of regulation of the gonadotrophin-releasing hormone receptor (GnRH-R) mRNA levels in the rat ovary. The demonstration of gonadotrophin-releasing hormone (GnRH) transcripts in steroidproducing and steroid-dependent tissues suggest…
There is increasing evidence to suggest that activin can function as an autocrine/paracrine regulator in various tissues, including the reproductive system. At the cellular level, activin acts via a family of activin receptor (ActR) subtypes which includes two type I (ActRI and ActRLB) and two type…
It is well established that LH action is mediated primarily by adenylate cyclase/cAMP. Conversely, the role of inositol phosphate/calcium in LH signalling has only recently been investigated. We examined the effects of gonadotrophins on intracellular calcium mobilisation in HEK293 cells transiently…
Superovulation causes detrimental effects, including embryonic loss and implantation failure. This study determined potential roles for insulin-like growth factor (IGF-I) in uterine environment regulation and preimplantation development, in conjunction with the detrimental effects of superovulation…
The placenta is an important endocrine organ producing large amounts of steroid and protein hormones which are released into the maternal and fetal circulations. Moreover, it has a very high metabolic rate and consumes a significant proportion of the oxygen and glucose delivered to the uterus and i…
The gonadotropin - releasing hormone (GnRH) receptor is a plasma membrane associated receptor and a member of the GTP - binding protein coupled receptor family. The interaction of the ligand, GnRH, and the GnRH receptor is a critical event in the endocrine control of reproduction. This coupling sti…
In vitro fertilization (IVF) has been achieved in several mammalian species, including humans. Using the technique of IVF and embryo transfer, pregnancies can now be established in infertile women and thousands of live births have occurred. However, many of the embryos transferred to the uterus fai…
This thesis investigated the expression and regulation of cytochrome P450s, aromatase (P450arom) and cholesterol side chain cleavage (P450scc) enzyme mRNAs in human granulosa-luteal cells using reverse transcription-polymerase chain reaction (RT-PCR). The two enzymes are instrumental in steroid hor…
In order to characterize and compare the pattern of inhibin production in the follicular phase between patients of the clomiphene citrate/human menopausal gonadotropin (hMG) and Buserelin/hMG protocols in in-vitro fertilization, serum inhibin levels from 20 patients in each protocol were measured. …
In order to characterize and compare the pattern of inhibin production in the follicular phase between patients of the clomiphene citrate/human menopausal gonadotropin (hMG) and Buserelin/hMG protocols in in-vitro fertilization, serum inhibin levels from 20 patients in each protocol were measured. …