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Bates' guide to physical examination and history taking

https://cwslc.andornot.com/en/permalink/catalog123792
Bickley, Lynn S., Szilagyi, Peter G. Philadelphia, PA: Lippincott Williams & Wilkins , 2023. 13th Ed.
Material Type
Book
Call Number
REF FA 100 BIC 2023
Availability
1 copy, 1 available
Confidently Perform Accurate, Efficient, and Effective Physical Examinations.; Master the techniques for successful physical examinations with the #1 choice for complete, authoritative guidance. This highly regarded text in book-only format includes fully-illustrated, step-by-step techniques that o…
Author
Bickley, Lynn S.
Szilagyi, Peter G.
Edition
13th Ed.
Place of Publication
Philadelphia, PA
Publisher
Lippincott Williams & Wilkins
Publication Date
2023
Physical Description
Hardcover: 1024 p.
Subject
General Medicine
Diagnostic Tests/Procedures. Physical Diagnosis
UBC MD Undergrad
Abstract
Confidently Perform Accurate, Efficient, and Effective Physical Examinations.
Master the techniques for successful physical examinations with the #1 choice for complete, authoritative guidance. This highly regarded text in book-only format includes fully-illustrated, step-by-step techniques that outline the correct performance of the physical examination and an easy-to-follow two-column format that correlates examination techniques on the left and abnormalities (clearly indicated in red) with differential diagnoses on the right.
ISBN
978-1975210533
Language
English
Material Type
Book
Call Number
REF FA 100 BIC 2023

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Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Vancouver Notes for Internal Medicine: High-Yield Consult Guides

https://cwslc.andornot.com/en/permalink/catalog125185
Vancouver, BC: Brush Education , 2022.
Material Type
Book
Call Number
REF AB 22 TAN 2022
Availability
2 copies, 2 available
A point-of-care guide for internal medicine trainees; When students and residents begin a new rotation in internal medicine, they often start from scratch, relying on their own research to prepare for consultations. What questions are crucial during history taking? What should the physical examinat…
Editor
Tang, Brandon
Zhuang, Meiying
Tessaro, James
Place of Publication
Vancouver, BC
Publisher
Brush Education
Publication Date
2022
Physical Description
424 pp
Subjects
Internal Medicine
Subject
Medical Directories. Resource Guides
UBC MD Undergrad
Abstract
A point-of-care guide for internal medicine trainees
When students and residents begin a new rotation in internal medicine, they often start from scratch, relying on their own research to prepare for consultations. What questions are crucial during history taking? What should the physical examination and investigations focus on? What should the consultation write-up include? Now, physician learners can turn to Vancouver Notes for Internal Medicine for guidance on conducting consultations in each of the core internal medicine subspecialties.
Vancouver Notes provides learners with an organized approach to common presentations in internal medicine. For each subspecialty, it lays out the process for identifying key information and communicating findings and management recommendations to a patient?s health-care team. Developed through the efforts of more than 90 resident physicians and faculty members at the University of British Columbia, Vancouver Notes combines valuable clinical pearls in a single, accessible resource to give students and residents the tools they need to succeed from day one.
ISBN
978-1550598995
Language
English
Material Type
Book
Call Number
REF AB 22 TAN 2022

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Copy 1 BC Children's and Women's Study and Learning Commons REF Available
Copy 2 BC Children's and Women's Study and Learning Commons REF Available
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West's Respiratory Physiology: The Essentials

https://cwslc.andornot.com/en/permalink/catalog123893
West, John B, Luks, Andrew M. New York: Wolters Kluwer , 2021. 11th.
Material Type
Book
Call Number
REF FN 102 WES 2021
Availability
1 copy, 1 available
For more than 40 years,West's Respiratory Physiology: The Essentialshas remained a critical resource for medical and allied health students learning the basics of respiratory physiology as well as an effective, quick review for residents and fellows in pulmonary medicine, critical care, anesthesiol…
Author
West, John B
Luks, Andrew M
Edition
11th
Place of Publication
New York
Publisher
Wolters Kluwer
Publication Date
2021
Physical Description
254 pp
Subject
Respiratory System/Respiratory Tract Diseases. Pulmonary Medicine
Abstract
For more than 40 years,West's Respiratory Physiology: The Essentialshas remained a critical resource for medical and allied health students learning the basics of respiratory physiology as well as an effective, quick review for residents and fellows in pulmonary medicine, critical care, anesthesiology, and internal medicine as they prepare for licensing and other exams. The eleventh edition incorporates updates in many areas including blood-tissue gas exchange, mechanics, control of ventilation and the respiratory system under stress; all designed to aid clear understanding of pulmonary physiology.
ISBN
9781-975139-186
Language
English
Material Type
Book
Call Number
REF FN 102 WES 2021

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Humble Inquiry: The Gentle Art of Asking Instead of Telling

https://cwslc.andornot.com/en/permalink/catalog125181
Schein, Edgar H, Schein, Peter A. Oakland, California: Berrett-Koehler Publishers , 2021. 2nd.
Material Type
Book
Call Number
REF AA 510 SCH 2021
Availability
3 copies, 3 available
This worldwide bestseller offers simple guidance for building the kind of open and trusting relationships vital for tackling global systemic challenges and developing adaptive, innovative organizations?over 200,000 copies sold and translated into seventeen languages!; We live, say Edgar and Peter S…
Author
Schein, Edgar H
Schein, Peter A
Edition
2nd
Place of Publication
Oakland, California
Publisher
Berrett-Koehler Publishers
Publication Date
2021
Physical Description
192 pp
Subjects
Leadership
Coaching
Subject
Leadership/Coaching
Abstract
This worldwide bestseller offers simple guidance for building the kind of open and trusting relationships vital for tackling global systemic challenges and developing adaptive, innovative organizations?over 200,000 copies sold and translated into seventeen languages!
We live, say Edgar and Peter Schein, in a culture of ?tell.? All too often we tell others what we think they need to know or should do. But whether we are leading or following, what matters most is we get to the truth. We have to develop a commitment to sharing vital facts and identifying faulty assumptions?it can mean the difference between success and failure. This is why we need Humble Inquiry more than ever.
The Scheins define Humble Inquiry as ?the gentle art of drawing someone out, of asking questions to which you do not know the answer, of building relationships based on curiosity and interest in the other person.? It was inspired by Edgar?s twenty years of work in high-hazard industries and the health-care system, where honest communication can literally mean the difference between life and death.
In this new edition the authors look at how Humble Inquiry differs from other kinds of inquiry, offer examples of it in action, and show how to overcome the barriers that keep us telling when we should be asking. This edition offers a deepening and broadening of this concept, seeing it as not just a way of posing questions but an entire attitude that includes better listening, better responding to what others are trying to tell us, and better revealing of ourselves. Packed with case examples and a full chapter of exercises and simulations, this is a major contribution to how we see human conversational dynamics and relationships, presented in a compact, personal, and eminently practical way.
ISBN
978-1523092628
Language
English
Material Type
Book
Call Number
REF AA 510 SCH 2021

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
Copy 2 BC Children's and Women's Study and Learning Commons REF Available
Copy 3 BC Children's and Women's Study and Learning Commons REF Available
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Washington manual of medical therapeutics

https://cwslc.andornot.com/en/permalink/catalog123797
Foster, Cory, Mistry, Neville, F. Philadelphia, PA: Lippincott Williams & Wilkins , 2020. 36th Ed.
Material Type
Book
Call Number
REF FA 100 FOS 2020
Availability
1 copy, 1 available
Established for more than 75 years,The Washington Manual of Medical Therapeutics, 36th Edition, provides concise, high-yield content that reflects today's fast-changing advances in medical technology and therapeutics. In one convenient, portable resource, you'll find complete coverage of every area…
Author
Foster, Cory
Mistry, Neville, F.
Edition
36th Ed.
Place of Publication
Philadelphia, PA
Publisher
Lippincott Williams & Wilkins
Publication Date
2020
Physical Description
Paperback; 1074 pages.
Subject
General Medicine
UBC MD Undergrad
Abstract
Established for more than 75 years,The Washington Manual of Medical Therapeutics, 36th Edition, provides concise, high-yield content that reflects today's fast-changing advances in medical technology and therapeutics. In one convenient, portable resource, you'll find complete coverage of every area of medicine and the core subspecialties?all at your fingertips for quick review and reference. Discover why housestaff and faculty worldwide depend on this best-selling resource for day-to-day clinical practice in internal medicine.
ISBN
978-1975-113483
Language
English
Material Type
Book
Call Number
REF FA 100 FOS 2020

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Harwood-Nuss' Clinical Practice of Emergency Medicine

https://cwslc.andornot.com/en/permalink/catalog125198
King, Brent, Loiselle, John. Philadelphia, PA: Wolters Kluwer , 2020. 6th.
Material Type
Book
Call Number
REF EB 800 WOL 2020
Availability
1 copy, 1 available
Harwood-Nuss' Clinical Practice of Emergency Medicine presents a clinically focused and evidence-based summary of emergency medicine. Chapters are templated to include the clinical presentation, differential diagnosis, evaluation, management and disposition, with highlighted critical interventions …
Author
King, Brent
Loiselle, John
Editor
Wolfson, Allan B
Edition
6th
Place of Publication
Philadelphia, PA
Publisher
Wolters Kluwer
Publication Date
2020
Physical Description
Hardcover, 1860 pp
Subjects
Pediatrics
Emergency Procedures
Subject
Emergency Medicine
Abstract
Harwood-Nuss' Clinical Practice of Emergency Medicine presents a clinically focused and evidence-based summary of emergency medicine. Chapters are templated to include the clinical presentation, differential diagnosis, evaluation, management and disposition, with highlighted critical interventions and common pitfalls. Management and disposition are especially critical in the emergency department, and their emphasis is unique to Harwood-Nuss. Often, a diagnosis can not be made, given the constraints of an ED evaluation; thus, effecive management of the patient, with or without a confirmed diagnosis, is key. Also distinct to Harwood-Nuss is the High-Risk Chief Complaints section, which covers the key presentations in the ED: chest pain, abdominal pain, shortness of breath, altered mental status. When patients present in the ED, they don't present with a known diagnosis; this chapter walks the physician through possible differential diagnoses and the evaluation and management of these patients so that they can be stabilized and treated quickly and effectively.
ISBN
978-1451188813
Language
English
Material Type
Book
Call Number
REF EB 800 WOL 2020

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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E-cadherin promotes tumorigenicity in human ovarian surface epithelium

https://cwslc.andornot.com/en/permalink/catalog113975
Ong, Aldrich Dixon. [Vancouver, BC?]: University of British Columbia , 1999.
Website
http://hdl.handle.net/2429/9760
Material Type
Thesis
Call Number
Thesis Shelf
Ovarian cancer is the most lethal gynecological cancer in the Western world, but comparatively little is known about its development. Epithelial ovarian carcinomas are thought to originate in the ovarian surface epithelium (OSE), i.e. the mesothelium covering the ovary, but experimental evidence fo…
Website
http://hdl.handle.net/2429/9760
Author
Ong, Aldrich Dixon
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1999
Subject
Faculty of Medicine
Theses
Abstract
Ovarian cancer is the most lethal gynecological cancer in the Western world, but comparatively little is known about its development. Epithelial ovarian carcinomas are thought to originate in the ovarian surface epithelium (OSE), i.e. the mesothelium covering the ovary, but experimental evidence for this origin has been lacking. Contrary to most epithelia where neoplastic progression is associated with loss of E-cadherin, this cell-cell adhesion molecule is sparse in normal human OSE but its expression increases in ovarian epithelial metaplasia and neoplasia.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Single cell studies of calcium as second messenger in human granulosa-lutein and embryonic kidney 293 cells

https://cwslc.andornot.com/en/permalink/catalog113979
Lee, Pearly S.N. [Vancouver, BC?]: University of British Columbia , 1999.
Website
http://hdl.handle.net/2429/10789
Material Type
Thesis
Call Number
Thesis Shelf
It is well established that LH action is mediated primarily by adenylate cyclase/cAMP. Conversely, the role of inositol phosphate/calcium in LH signalling has only recently been investigated. We examined the effects of gonadotrophins on intracellular calcium mobilisation in HEK293 cells transiently…
Website
http://hdl.handle.net/2429/10789
Author
Lee, Pearly S.N.
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1999
Subject
Faculty of Medicine
Theses
Abstract
It is well established that LH action is mediated primarily by adenylate cyclase/cAMP. Conversely, the role of inositol phosphate/calcium in LH signalling has only recently been investigated. We examined the effects of gonadotrophins on intracellular calcium mobilisation in HEK293 cells transiently transfected with human wild type or chimeric gonadotrophs receptors (n=3400). Intracellular free calcium concentration was measured using fura-2 microspectrofluorimetric techniques. Human LH (2-4 μg/ml) arid CG (10 IU/ml) consistently evoked oscillatory calcium signals in HEK293 cells transfected with hLHr, whereas hFSH (2-4 μg/ml) failed to elicit any calcium responses.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
Show Less

Hindlimb blood flow and oxygen consumption in the late gestation fetal lamb

https://cwslc.andornot.com/en/permalink/catalog113991
Knight, Kathleen Elizaabeth. [Vancouver, BC?]: University of British Columbia , 1998.
Website
http://hdl.handle.net/2429/9896
Material Type
Thesis
Call Number
Thesis Shelf
The purpose of this research was to examine hindlimb blood flow and oxygen supply in the late-gestation fetal lamb under normal and pathophysiological conditions. Although the carcass, or non-visceral tissue, accounts for a large proportion of fetal weight and oxygen demand, it has received little …
Website
http://hdl.handle.net/2429/9896
Author
Knight, Kathleen Elizaabeth
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1998
Subject
Faculty of Medicine
Theses
Abstract
The purpose of this research was to examine hindlimb blood flow and oxygen supply in the late-gestation fetal lamb under normal and pathophysiological conditions. Although the carcass, or non-visceral tissue, accounts for a large proportion of fetal weight and oxygen demand, it has received little research attention. Because the hindlimb is composed of skin, bone, and skeletal muscle, it is representative of the carcass
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
Show Less

Mendelian inheritance in man: A catalog of human genes and genetic disorders: Vol 1

https://cwslc.andornot.com/en/permalink/catalog112687
McKusiak, Victor A (Ed). Baltimore, MD: Johns Hopkins University Press , 1998. 12th Ed.
Website
http://www.ncbi.nlm.nih.gov/omim
Material Type
Book
Call Number
REF GI 20 MCK 1998 VOL 1
Availability
2 copies, 2 available
A comprehensive, authoritative and timely knowledgebase of human genes and genetic disorders compiled to support human genetics research and education and the practice of clinical genetics.
Website
http://www.ncbi.nlm.nih.gov/omim
Website Notes
The database corresponds to the print publication.
Author
McKusiak, Victor A (Ed).
Edition
12th Ed.
Place of Publication
Baltimore, MD
Publisher
Johns Hopkins University Press
Publication Date
1998
Physical Description
Hardcover
Subject
Genetics
Genetic Disorders
Genetics/Genetic Disorders-Encyclopedias
Abstract
A comprehensive, authoritative and timely knowledgebase of human genes and genetic disorders compiled to support human genetics research and education and the practice of clinical genetics.
ISBN
0801857422
Language
English
Material Type
Book
Call Number
REF GI 20 MCK 1998 VOL 1

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
Copy 2 BC Children's and Women's Study and Learning Commons REF Available
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Mendelian inheritance in man: A catalog of human genes and genetic disorders: Vol 2

https://cwslc.andornot.com/en/permalink/catalog112688
McKusiak, Victor A (Ed). Baltimore, MD: Johns Hopkins University Press , 1998. 12th Ed.
Website
http://www.ncbi.nlm.nih.gov/omim
Material Type
Book
Call Number
REF GI 20 MCK 1998 VOL 2
Availability
2 copies, 2 available
A comprehensive, authoritative and timely knowledgebase of human genes and genetic disorders compiled to support human genetics research and education and the practice of clinical genetics.
Website
http://www.ncbi.nlm.nih.gov/omim
Website Notes
The database corresponds to the print publication.
Author
McKusiak, Victor A (Ed).
Edition
12th Ed.
Place of Publication
Baltimore, MD
Publisher
Johns Hopkins University Press
Publication Date
1998
Physical Description
Hardcover
Subject
Genetics
Genetics/Genetic Disorders-Encyclopedias
Genetic Disorders
Abstract
A comprehensive, authoritative and timely knowledgebase of human genes and genetic disorders compiled to support human genetics research and education and the practice of clinical genetics.
ISBN
0801857422
Language
English
Material Type
Book
Call Number
REF GI 20 MCK 1998 VOL 2

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
Copy 2 BC Children's and Women's Study and Learning Commons REF Available
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Mendelian inheritance in man: A catalog of human genes and genetic disorders: Vol 3

https://cwslc.andornot.com/en/permalink/catalog112689
McKusiak, Victor A (Ed). Baltimore, MD: Johns Hopkins University Press , 1998.
Website
http://www.ncbi.nlm.nih.gov/omim
Material Type
Book
Call Number
REF GI 20 MCK 1998 VOL 3
Availability
2 copies, 2 available
A comprehensive, authoritative and timely knowledgebase of human genes and genetic disorders compiled to support human genetics research and education and the practice of clinical genetics.
Website
http://www.ncbi.nlm.nih.gov/omim
Website Notes
The database corresponds to the print publication.
Author
McKusiak, Victor A (Ed).
Place of Publication
Baltimore, MD
Publisher
Johns Hopkins University Press
Publication Date
1998
Physical Description
Hardcover
Subject
Genetic Disorders
Genetics
Genetics/Genetic Disorders-Encyclopedias
Abstract
A comprehensive, authoritative and timely knowledgebase of human genes and genetic disorders compiled to support human genetics research and education and the practice of clinical genetics.
ISBN
0801857422
Language
English
Material Type
Book
Call Number
REF GI 20 MCK 1998 VOL 3

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
Copy 2 BC Children's and Women's Study and Learning Commons REF Available
Websites
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Prostaglandin F[sub 2a]-mediated luteolytic and luteotrophic effects on the human granulosa-luteal cell

https://cwslc.andornot.com/en/permalink/catalog113976
Vaananen, Jeffrey Eric. [Vancouver, BC?]: University of British Columbia , 1997.
Website
http://hdl.handle.net/2429/6811
Material Type
Thesis
Call Number
Thesis Shelf
These studies examined the effects of prostaglandin-F[sub 2a] (PGF[sub 2a]) on progesterone and 178-estradiol (estradiol) production, as well as DNA and PGF[sub 2a]-receptor (PGF[sub 2a]-R) mRNA levels, in the human granulosa-luteal cell (GLC). Additionally, the interactions of PGF[sub 2a] with hum…
Website
http://hdl.handle.net/2429/6811
Author
Vaananen, Jeffrey Eric
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1997
Subject
Faculty of Medicine
Theses
Abstract
These studies examined the effects of prostaglandin-F[sub 2a] (PGF[sub 2a]) on progesterone and 178-estradiol (estradiol) production, as well as DNA and PGF[sub 2a]-receptor (PGF[sub 2a]-R) mRNA levels, in the human granulosa-luteal cell (GLC). Additionally, the interactions of PGF[sub 2a] with human chorionic gonadotrophin (hCG), gonadotrophin-releasing hormone (GnRH) and prostaglandin E₂ (PGE₂) were examined, with respect to progesterone and estradiol production.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Regulation of rat ovarian gonadotropin Releasing hormone receptor mRNA levels

https://cwslc.andornot.com/en/permalink/catalog113977
Vaananen, Celine Claire. [Vancouver, BC?]: University of British Columbia , 1997.
Website
http://hdl.handle.net/2429/6615
Material Type
Thesis
Call Number
Thesis Shelf
The studies undertaken herewithin sought to characterize the pattern of regulation of the gonadotrophin-releasing hormone receptor (GnRH-R) mRNA levels in the rat ovary. The demonstration of gonadotrophin-releasing hormone (GnRH) transcripts in steroidproducing and steroid-dependent tissues suggest…
Website
http://hdl.handle.net/2429/6615
Author
Vaananen, Celine Claire
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1997
Subject
Faculty of Medicine
Theses
Abstract
The studies undertaken herewithin sought to characterize the pattern of regulation of the gonadotrophin-releasing hormone receptor (GnRH-R) mRNA levels in the rat ovary. The demonstration of gonadotrophin-releasing hormone (GnRH) transcripts in steroidproducing and steroid-dependent tissues suggests that GnRH may be implicated in the modulation of steroid action in those target tissues. Expression of GnRH-R mRNA increases in gonadal tissues and the pituitary with age, supporting the concept of GnRH as a local regulator in the developing rat as well as in the adult.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Localization and regulation of mRNA transcripts encoding activin receptors in human placental trophoblast cells

https://cwslc.andornot.com/en/permalink/catalog113978
Chen, Victor. [Vancouver, BC?]: University of British Columbia , 1997.
Website
http://hdl.handle.net/2429/6315
Material Type
Thesis
Call Number
Thesis Shelf
There is increasing evidence to suggest that activin can function as an autocrine/paracrine regulator in various tissues, including the reproductive system. At the cellular level, activin acts via a family of activin receptor (ActR) subtypes which includes two type I (ActRI and ActRLB) and two type…
Website
http://hdl.handle.net/2429/6315
Author
Chen, Victor
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1997
Subject
Faculty of Medicine
Theses
Abstract
There is increasing evidence to suggest that activin can function as an autocrine/paracrine regulator in various tissues, including the reproductive system. At the cellular level, activin acts via a family of activin receptor (ActR) subtypes which includes two type I (ActRI and ActRLB) and two type II (II and ILB) receptors. The role of activin in the human placenta is not clearly understood. In this study, the detection of inlubin/activin subunit and ActRI mRNA were examined in first trimester cytotrophoblasts, term cytotrophoblasts, extravillous trophoblast (EVT) cells, immortalized extravillous trophoblast (LEVT) cells, JEG-3 cells, decidual tissue, and decidual cells.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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The role for insulin-like growth factor-I in preimplantation embryonic development and decidualization following superovulation in the rat

https://cwslc.andornot.com/en/permalink/catalog113980
Katagiri, Seiji. [Vancouver, BC?]: University of British Columbia , 1996.
Website
http://hdl.handle.net/2429/4814
Material Type
Thesis
Call Number
Thesis Shelf
Superovulation causes detrimental effects, including embryonic loss and implantation failure. This study determined potential roles for insulin-like growth factor (IGF-I) in uterine environment regulation and preimplantation development, in conjunction with the detrimental effects of superovulation…
Website
http://hdl.handle.net/2429/4814
Author
Katagiri, Seiji
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1996
Subject
Faculty of Medicine
Theses
Abstract
Superovulation causes detrimental effects, including embryonic loss and implantation failure. This study determined potential roles for insulin-like growth factor (IGF-I) in uterine environment regulation and preimplantation development, in conjunction with the detrimental effects of superovulation in the rat. IGF-I may be beneficial to preimplantation embryonic development. IGF-I stimulated embryonic development and metabolism in vitro and increased the rate of implantation and fetal development when the blastocysts were transferred into a receptive uterus.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Maternal progesterone and fetal cortisol responses to hypoxemia in pregnant sheep

https://cwslc.andornot.com/en/permalink/catalog113981
Wu, Li-Hua. [Vancouver, BC?]: University of British Columbia , 1996.
Website
http://hdl.handle.net/2429/4269
Material Type
Thesis
Call Number
Thesis Shelf
The placenta is an important endocrine organ producing large amounts of steroid and protein hormones which are released into the maternal and fetal circulations. Moreover, it has a very high metabolic rate and consumes a significant proportion of the oxygen and glucose delivered to the uterus and i…
Website
http://hdl.handle.net/2429/4269
Author
Wu, Li-Hua
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1996
Subject
Faculty of Medicine
Theses
Abstract
The placenta is an important endocrine organ producing large amounts of steroid and protein hormones which are released into the maternal and fetal circulations. Moreover, it has a very high metabolic rate and consumes a significant proportion of the oxygen and glucose delivered to the uterus and its contents. However, while there have been many studies on the effects of hypoxemia on fetal cardiovascular, metabolic and endocrine functions, there are limited data on the effects of reduced oxygenation on placental endocrine activities. In the present study, we examined the effects of acute (2-h) moderate (maternal Pao₂ lowered by 27-35%, n=5) and severe (maternal Pao₂ lowered by 41-58%, n=4) hypoxemia on placental progesterone output into the maternal circulation in 7 chronically instrumented pregnant sheep (125 to 136 d). Hypoxemia was achieved by lowering maternal inspired O₂ concentration and the hypoxemia period was preceded and followed by 2 h pre-hypoxia and recovery periods, respectively. Control experiments (n=4), involving 6 h periods of normoxia were also carried out.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
Show Less

Characterization of the human gonadotropin-releasing hormone receptor gene at the molecular level

https://cwslc.andornot.com/en/permalink/catalog113982
Fan, Nancy C. [Vancouver, BC?]: University of British Columbia , 1995.
Website
http://hdl.handle.net/2429/7255
Material Type
Thesis
Call Number
Thesis Shelf
The gonadotropin - releasing hormone (GnRH) receptor is a plasma membrane associated receptor and a member of the GTP - binding protein coupled receptor family. The interaction of the ligand, GnRH, and the GnRH receptor is a critical event in the endocrine control of reproduction. This coupling sti…
Website
http://hdl.handle.net/2429/7255
Author
Fan, Nancy C.
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1995
Subject
Faculty of Medicine
Theses
Abstract
The gonadotropin - releasing hormone (GnRH) receptor is a plasma membrane associated receptor and a member of the GTP - binding protein coupled receptor family. The interaction of the ligand, GnRH, and the GnRH receptor is a critical event in the endocrine control of reproduction. This coupling stimulates the synthesis and release of both luteinizing hormone and follicle stimulating hormone from the anterior pituitary. In addition, GnRH - GnRH receptor binding acts locally to regulate human chorionic gonadotropin secretion in the placenta and steroidogenesis in the ovary. The objective of this thesis was to isolate and characterize the gene for the GnRH receptor in human.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
Show Less

Superovulation and chromosomal aberrations

https://cwslc.andornot.com/en/permalink/catalog113983
Ma, Sai. [Vancouver, BC?]: University of British Columbia , 1995.
Website
http://hdl.handle.net/2429/7516
Material Type
Thesis
Call Number
Thesis Shelf
In vitro fertilization (IVF) has been achieved in several mammalian species, including humans. Using the technique of IVF and embryo transfer, pregnancies can now be established in infertile women and thousands of live births have occurred. However, many of the embryos transferred to the uterus fai…
Website
http://hdl.handle.net/2429/7516
Author
Ma, Sai
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1995
Subject
Faculty of Medicine
Theses
Abstract
In vitro fertilization (IVF) has been achieved in several mammalian species, including humans. Using the technique of IVF and embryo transfer, pregnancies can now be established in infertile women and thousands of live births have occurred. However, many of the embryos transferred to the uterus fail to achieve or sustain implantation. The failure of implantation has raised questions about the possible detrimental effect of superovulation on chromosomal complements. In this study, the hypothesis that chromosomal aberrations exist in mouse preimplantation embryos and human unfertilized oocytes after superovulation, was tested. The incidence of aneuploidy in spontaneously ovulated group (5.6%) was similar to that reported by others.
Language
English
Material Type
Thesis
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Regulation of cytochrome P450 and P450 mRNA in human granulosa-luteal cells

https://cwslc.andornot.com/en/permalink/catalog113984
Ge, Hong. [Vancouver, BC?]: University of British Columbia , 1994.
Website
http://hdl.handle.net/2429/3482
Material Type
Thesis
Call Number
Thesis Shelf
This thesis investigated the expression and regulation of cytochrome P450s, aromatase (P450arom) and cholesterol side chain cleavage (P450scc) enzyme mRNAs in human granulosa-luteal cells using reverse transcription-polymerase chain reaction (RT-PCR). The two enzymes are instrumental in steroid hor…
Website
http://hdl.handle.net/2429/3482
Author
Ge, Hong
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1994
Subject
Faculty of Medicine
Theses
Abstract
This thesis investigated the expression and regulation of cytochrome P450s, aromatase (P450arom) and cholesterol side chain cleavage (P450scc) enzyme mRNAs in human granulosa-luteal cells using reverse transcription-polymerase chain reaction (RT-PCR). The two enzymes are instrumental in steroid hormone biosynthesis.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
Show Less

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