Website

http://hdl.handle.net/2429/29313

Author

Wang, Jian

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1989

Subject

Faculty of Medicine

Theses

Abstract

The present study was conducted to investigate the hypothesis that membrane phosphoinositide breakdown may participate in the actions of luteinizing hormone-releasing hormone (LHRH) on hormone production in the rat ovary. In granulosa cells prelabeled with [³H]-arachidonic acid or [³H]-inositol, treatment with LHRH increased the accumulation of radiolabeled inositol lipids, diacylglycerol and free arachidonic acid, but luteinizing hormone (LH) or cholera toxin did not exert the same effect. Activation of protein kinase C by the phorbol ester, 12-0-tetradecanoyl phorbol-13-acetate (TPA) had a stimulatory action on membrane phosphoinositide breakdown.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/945

Author

Tang, Steven Siu Yan

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2008

Subject

Faculty of Medicine

Theses

Abstract

Intracytoplasmic sperm injection (ICSI) has been a successful assisted reproductive technique for men with severe male-factor infertility. However, ICSI requires the subjective selection of normal looking sperm, which does not preclude the transmission of genetically abnormal sperm. Correlation between abnormal sperm morphology and chromosomal abnormalities has been suggested but not been conclusive and less is known about the connection between sperm morphology and DNA integrity. Sperm morphology will be evaluated on its ability to identify the level of chromosomal abnormalities or fragmented DNA in sperm. To further focus this investigation on sperm morphology, men with infertility isolated to abnormal sperm morphology (isolated teratozoopsermia) are examined.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://www.perinatalservicesbc.ca/Documents/Guidelines-Standards/Maternal/MentalHealthDisordersGuideline.pdf

Corporate Author

BC Reproductive Mental Health Program

Perinatal Services BC

Place of Publication

[Vancouver, BC?]

Publisher

BC Reproductive Mental Health

Publication Date

2014

Physical Description

Softcover: 90 p.

Subject

Pregnancy/Childbirth. Obstetrics

Mental Health/Illness

Prenatal Care

Mental Health

Anxiety

Abstract

These guidelines are designed to support healthcare clinicians with early detection and treatment of mental health disorders in pregnant and postpartum women.

The guidelines include:

• an overview of mental health disorders in the perinatal period;

• four common disorders: depression, anxiety disorders, bipolar disorder, and psychotic disorders, including postpartum psychosis; and

• education and prevention, screening and diagnosis, treatment, and recommendations for each disorder.

Notes

Please note that the version for sale is in BLACK & WHITE only.

Language

English

Material Type

Book

Call Number

REF GH 200 BCR 2014

Copies

Website

http://hdl.handle.net/2429/14957

Author

Zhou, Junshan

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2003

Subject

Faculty of Medicine

Theses

Abstract

Remodeling of the endometrial extracellular matrix, which occurs during the early stages of pregnancy in the human, is mediated by the temporal expression of urokinase-type plasminogen activator (uPA) and matrix metalloproteinases (MMP) in both the maternal and fetal compartments and counterbalanced by their respective endogenous inhibitors, plasminogen activator inhibitor (PAI-1) and tissue inhibitors of metalloproteinases (TIMPs) in both an autocrine and paracrine manner. To date, the factors capable of regulating the expression of uPA and MMP proteolytic systems at the maternal-fetal interface remain poorly characterized.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

1000awesomethings.com

Author

Pasricha, Neil

Place of Publication

New York, NY

Publisher

Berkley

Publication Date

2010

Physical Description

Paperback: 393 p.

Subject

Leadership/Coaching

Abstract

The Book of Awesome is a high five for humanity and a big celebration of life's little moments and the underappreciated, simple things that make us happy.

ISBN

9780425238905

Language

English

Material Type

Book

Call Number

REF AA 75 PAS 2010

Copies

Website

PHSA Users:

http://web.a.ebscohost.com/pfi/detail/detail?vid=15&sid=80dd29ce-f1c9-480f-93d5-346abac169f7%40sessionmgr4009&hid=4106&bdata=JnNpdGU9cGZpLWxpdmU%3d#AN=edp15358&db=edspub

UBC Users:

http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=AC_T_B&C=Canadian+journal+of+rural+medicine

Alternate Title

Canadian journal of rural medicine : the official journal of the Society of Rural Physicians of Canada = Journal canadien de la médecine rurale : le journal officiel de la Société de médecine rurale du Canada.

Corporate Author

Society of Rural Physicians of Canada

Place of Publication

[Ottawa, ON]

Publisher

Canadian Medical Association

Publication Date

1996 - Present

Notes

Articles in English; some are also in French.

ISSN

1203-7796

Language

English, French

Material Type

Serial

Frequency

Quarterly

Holdings

CFRI/Study & Learning Commons - Print:v.10:1-v.15:4 (2005-2010); v.16:3 (2011); v.17:1-2 (2012).

Missing: v.8:2-4 (2003); v.9:1-4 (2004); v.11:4 (2006); v.12:4 (2007); v.13:2 (2008).

Online: 1996 to present.

Website

http://hdl.handle.net/2429/44653

Author

Nguyen, Tuan-Anh Thi

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2013

Subject

Faculty of Medicine

Theses

Abstract

Human newborns exposed in utero to maternally administered SSRIs such as fluoxetine (FX) have an increased risk of adverse pregnancy outcomes including poor neonatal adaptation. This comprises respiratory difficulty, jitteriness, cyanosis when feeding and persists for several days after birth. Several potential mechanisms underlying these symptoms have been proposed: 1) acute toxicity to the drugs (i.e. serotonin syndrome), 2) withdrawal syndrome due to the sudden discontinuation of maternal-fetal placental drug transfer at birth or 3) an SSRIs-elicited alteration in fetal brain development. However, the actual mechanism has not been elucidated.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/29783

Author

Zou, Junxuan

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2010

Subject

Faculty of Medicine

Theses

Abstract

The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We examined the presence of ADAMTS in first trimester human placenta and only ADAMTS-12 was present in cultures of invasive extravillous cytotrophoblast (EVT) at significantly higher levels than in poorly invasive JEG-3 chorocarcinoma cells. Immunohistochemistry staining of chorionic villi derived from first trimester human placenta demonstrated that ADAMTS-12 was intensively immunolocalized in the cytotrophoblast layer but weakly immunolocalized in the poorly-invasive syncytial trophoblast layer.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/7255

Author

Fan, Nancy C.

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1995

Subject

Faculty of Medicine

Theses

Abstract

The gonadotropin - releasing hormone (GnRH) receptor is a plasma membrane associated receptor and a member of the GTP - binding protein coupled receptor family. The interaction of the ligand, GnRH, and the GnRH receptor is a critical event in the endocrine control of reproduction. This coupling stimulates the synthesis and release of both luteinizing hormone and follicle stimulating hormone from the anterior pituitary. In addition, GnRH - GnRH receptor binding acts locally to regulate human chorionic gonadotropin secretion in the placenta and steroidogenesis in the ovary. The objective of this thesis was to isolate and characterize the gene for the GnRH receptor in human.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/30332

Author

Sheu, Fong-Shyong

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1991

Subject

Faculty of Medicine

Theses

Abstract

By using modified hybridoma technology, monoclonal antibodies against an ovarian tumor cell line, OC-3-VGH, were generated in Dr. Lee's laboratory. Among these antibodies, RP 215 was shown to react specifically with a tumor-associated antigen, COX-1. On SDS gel, COX-1 has a molecular weight of 60 KD and exists as an aggregate in the natural- state. A highly purified COX-1 was obtained mainly by immunoaffirtity chromatography, with RP 215 as the affinity ligand, from the shed medium of cultured tumor cells.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://www.cw.bc.ca/library/pdf/2013PeerNavigatorToolkit.pdf

Author

Kwong, Sandy

Place of Publication

[Vancouver, BC?]

Publisher

BC Cancer Agency

Publication Date

2013

Physical Description

Softcover: 27 p.

Subject

Cancer-Coping

Cancer

Abstract

This guide describes the principles and processes involved in the development of the Chinese Peer Navigator Program at the BC Cancer Agency, Vancouver Centre and the bilingual resources that are used with Chinese-speaking patients (Mandarin, Cantonese and English).

This program also reflects “best practice” standards and can be used for future groups or organizations who may wish to adapt it for future peer navigator programs.

Language

English

Chinese

Material Type

Book

Call Number

REF FE 220 CHI 2013

Copies

Website

http://hdl.handle.net/2429/9705

Author

Kirkpatrick, Gordon

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2009

Subject

Faculty of Medicine

Theses

Abstract

Male carriers of chromosomal abnormalities (CA) are more frequent in the infertile population. These men have higher levels of sperm aneuploidy due to the aberrant segregation of the chromosomes involved in the abnormality. The presence of a CA may also influence the segregation of other chromosomes, in a process known as in interchromosomal effect (ICE). The behaviour of the CA during meiosis may account for the infertility observed in this population. We studied chromosome segregation, ICE and meiotic defects in a variety of CA. In carriers of CA, we determined the segregation patterns of chromosomes involved in the abnormality.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/1395

Author

Nguyen, Tuan-Anh T

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2008

Subject

Faculty of Medicine

Theses

Abstract

Due to the ?flare effect? associated with the flare protocol, variation in the degree of follicular maturation during stimulation may result in differences in follicle response as compared to the luteal protocol which is based on maximal pituitary suppression and synchronization of follicular maturation. In this study, besides other methods, Anti-Mullerian Hormone (AMH), a novel marker for ovarian reserve, was used as a tool to evaluate the ovarian responsiveness to stimulation.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

PHSA Users:

http://web.b.ebscohost.com/pfi/detail/detail?sid=8eead011-1960-4015-b7da-0e70b0435dd6%40sessionmgr105&vid=0&hid=118&bdata=JnNpdGU9cGZpLWxpdmU%3d#AN=edp18037&db=edspub

UBC Users:

http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=AC_T_B&C=clinical+and+investigative+medicine

Place of Publication

[Ottawa, ON]

Publisher

Canadian Society for Clinical Investigation (CSCI)

Publication Date

1978 - Present

Notes

Print issues ceased with v. 29, no. 5 (Dec. 2006)

Articles in English; summaries in English and French

ISSN

0147-958X

Language

English

Material Type

Serial

Frequency

Bimonthly

Holdings

CFRI/Study & Learning Commons - Print: v.17:1-v.29:6+suppls.

Missing: v.19:3 (1996); v.24:5 (2001).

Online: 1996 to present.

Website

PHSA Users:

http://search.ebscohost.com/login.aspx?direct=true&db=edspub&AN=edp18084&site=pfi-live

UBC Users:

http://gw2jh3xr2c.search.serialssolutions.com/?SS_searchTypeJournal=yes&V=1.0&L=GW2JH3XR2C&S=AC_T_B&C=clinical+genetics

Place of Publication

Malden, Ma.

Publisher

John Wiley & Sons, Inc.

Publication Date

1970 - Present.

ISSN

0009-9163

Language

English

Material Type

Serial

Frequency

Monthly

Holdings

CFRI/Study & Learning Commons - Print: v.45:6-v.57:4+special issue (1994-2000); v.61:1 (2002); v.69:3-v.76:3 (2006-2009).

Missing: v.51:3, v.52:4 (1997); v.53:2 (1998); v.55:4, v.56:1,3 (1999); v.57:1-3, v.58:1-6 (2000); v.59:1-6, v.60:1-6 (2001); v.61:2-6, v.62:1-6 (2002); 2003-2005; v.69:1-2 (2006); v.73:3-5 (2008); v.75:1,3,4, v.76:2,4-6 (2009).

Online: 1970 to present.

Website

http://www.cw.bc.ca/library/pdf/Risk communication book remediated2.pdf

Website Notes

Click on the link above to view/print.

Author

Fischhoff, Baruch

Brewer, Noel T.

Downs, Julie S.(eds.)

Corporate Author

Food & Drug Administration (FDA), US Department of Health & Human Services

Place of Publication

Maryland, USA

Publisher

FDA, US Department of Health & Human Services

Publication Date

2011

Physical Description

PDF file: 242 p.

Subject

Leadership/Coaching

Communication

Abstract

Effective risk communication is essential to the well-being of any organization and those people who depend on it. Ineffective communication can cost lives, money, and reputations. Communicating Risks and Benefits: An Evidence-Based User's Guide provides the scientific foundations for effective communication.

Language

English

Material Type

Book

Online

Website

http://hdl.handle.net/2429/29282

Author

Minor, Agata

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2010

Subject

Faculty of Medicine

Theses

Abstract

Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA methylation would be present in the ejaculate and testicular sperm of men affected by severe male factor infertility compared to that in fertile control men. Furthermore, we hypothesized abnormal DNA methylation would also affect non-imprinted genes in the sperm of men affected by severe oligozoospermia.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/9760

Author

Ong, Aldrich Dixon

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1999

Subject

Faculty of Medicine

Theses

Abstract

Ovarian cancer is the most lethal gynecological cancer in the Western world, but comparatively little is known about its development. Epithelial ovarian carcinomas are thought to originate in the ovarian surface epithelium (OSE), i.e. the mesothelium covering the ovary, but experimental evidence for this origin has been lacking. Contrary to most epithelia where neoplastic progression is associated with loss of E-cadherin, this cell-cell adhesion molecule is sparse in normal human OSE but its expression increases in ovarian epithelial metaplasia and neoplasia.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/28961

Author

Shi, Fengtao

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2010

Subject

Faculty of Medicine

Theses

Abstract

Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regulator of ovarian function, but its overall effects, particularly relating to activin A actions, are unknown. We examined the potential crosstalk between activin A and GDF9 in primary cultures of human granulosa-lutein (hGL) cells. Pretreatment of hGL cells with GDF9 for 24 h resulted in an increased expression of activin receptors and Smad2/3, and decreased inhibitory Smad7 activity. These effects were attenuated by BMP type II receptor ectodomain (BMPR2 ECD), a GDF9 antagonist.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf

Website

http://hdl.handle.net/2429/28984

Author

Feng, Tian Bin

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1990

Subject

Faculty of Medicine

Theses

Abstract

In the present study, the effects of clomiphene citrate (CC) on ovulation, ovarian growth and ovarian steroidogenesis were examined. Ovulation in rats in response to PMSG was completely blocked by administration of three daily treatments of 1.0 mg CC/rat, but was restored by administration of hCG as a preovulatory LH surge substitute. When the number of treatment days was reduced to two days, 1.0 mg of CC enhanced ovulation in response to PMSG, whereas treatment for one day with the same dose of CC did not affect ovulation.

Language

English

Material Type

Thesis

Call Number

Thesis Shelf