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Case files: Internal medicine

https://cwslc.andornot.com/en/permalink/catalog114803
Toy, Eugene, Patlan, John, Warner, Mark T. New York, NY: McGraw-Hill Education , 2017. 5th ed.
Material Type
Book
Call Number
REF AB 60 TOY 2017
Availability
2 copies, 2 available
Experience with clinical cases is key to mastering the art and science of medicine. This book provides 60 true-to-life cases that illustrate essential concepts in Internal Medicine. Each case includes a discussion correlated to key concepts, definitions of key terms, clinical pearls, and board-styl…
Author
Toy, Eugene
Patlan, John
Warner, Mark T.
Edition
5th ed.
Place of Publication
New York, NY
Publisher
McGraw-Hill Education
Publication Date
2017
Physical Description
Paperback, 588 p.
Subject
Internal Medicine
Abstract
Experience with clinical cases is key to mastering the art and science of medicine. This book provides 60 true-to-life cases that illustrate essential concepts in Internal Medicine. Each case includes a discussion correlated to key concepts, definitions of key terms, clinical pearls, and board-style review questions to reinforce your learning.
ISBN
9780071843355
Language
English
Material Type
Book
Call Number
REF AB 60 TOY 2017

Copies

copy 1 BC Children's and Women's Study and Learning Commons MISSING Available
Copy 2 BC Children's and Women's Study and Learning Commons REF Available
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The characterization of ADAMTS-12 in the regulation of human trophoblast invasion in vitro

https://cwslc.andornot.com/en/permalink/catalog113949
Zou, Junxuan. [Vancouver, BC?]: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/29783
Material Type
Thesis
Call Number
Thesis Shelf
The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We ex…
Website
http://hdl.handle.net/2429/29783
Author
Zou, Junxuan
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
The distintegrin-like and metalloproteinase with thrombospondin repeats (ADAMTS) are members of a gene family of secreted, multidomain and multifunctional proteinases that are able to proteolytically degrade a diverse array of cellular, extracellular and extracellular matrix (ECM) substrates. We examined the presence of ADAMTS in first trimester human placenta and only ADAMTS-12 was present in cultures of invasive extravillous cytotrophoblast (EVT) at significantly higher levels than in poorly invasive JEG-3 chorocarcinoma cells. Immunohistochemistry staining of chorionic villi derived from first trimester human placenta demonstrated that ADAMTS-12 was intensively immunolocalized in the cytotrophoblast layer but weakly immunolocalized in the poorly-invasive syncytial trophoblast layer.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Characterization of the human gonadotropin-releasing hormone receptor gene at the molecular level

https://cwslc.andornot.com/en/permalink/catalog113982
Fan, Nancy C. [Vancouver, BC?]: University of British Columbia , 1995.
Website
http://hdl.handle.net/2429/7255
Material Type
Thesis
Call Number
Thesis Shelf
The gonadotropin - releasing hormone (GnRH) receptor is a plasma membrane associated receptor and a member of the GTP - binding protein coupled receptor family. The interaction of the ligand, GnRH, and the GnRH receptor is a critical event in the endocrine control of reproduction. This coupling sti…
Website
http://hdl.handle.net/2429/7255
Author
Fan, Nancy C.
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1995
Subject
Faculty of Medicine
Theses
Abstract
The gonadotropin - releasing hormone (GnRH) receptor is a plasma membrane associated receptor and a member of the GTP - binding protein coupled receptor family. The interaction of the ligand, GnRH, and the GnRH receptor is a critical event in the endocrine control of reproduction. This coupling stimulates the synthesis and release of both luteinizing hormone and follicle stimulating hormone from the anterior pituitary. In addition, GnRH - GnRH receptor binding acts locally to regulate human chorionic gonadotropin secretion in the placenta and steroidogenesis in the ovary. The objective of this thesis was to isolate and characterize the gene for the GnRH receptor in human.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Characterizations of a tumor-associated antigen COX-1

https://cwslc.andornot.com/en/permalink/catalog113988
Sheu, Fong-Shyong. [Vancouver, BC?]: University of British Columbia , 1991.
Website
http://hdl.handle.net/2429/30332
Material Type
Thesis
Call Number
Thesis Shelf
By using modified hybridoma technology, monoclonal antibodies against an ovarian tumor cell line, OC-3-VGH, were generated in Dr. Lee's laboratory. Among these antibodies, RP 215 was shown to react specifically with a tumor-associated antigen, COX-1. On SDS gel, COX-1 has a molecular weight of 60 K…
Website
http://hdl.handle.net/2429/30332
Author
Sheu, Fong-Shyong
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1991
Subject
Faculty of Medicine
Theses
Abstract
By using modified hybridoma technology, monoclonal antibodies against an ovarian tumor cell line, OC-3-VGH, were generated in Dr. Lee's laboratory. Among these antibodies, RP 215 was shown to react specifically with a tumor-associated antigen, COX-1. On SDS gel, COX-1 has a molecular weight of 60 KD and exists as an aggregate in the natural- state. A highly purified COX-1 was obtained mainly by immunoaffirtity chromatography, with RP 215 as the affinity ligand, from the shed medium of cultured tumor cells.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Chinese cancer patient peer navigator toolkit: A model for language-based peer navigation

https://cwslc.andornot.com/en/permalink/catalog112530
Kwong, Sandy. [Vancouver, BC?]: BC Cancer Agency , 2013.
Website
http://www.cw.bc.ca/library/pdf/2013PeerNavigatorToolkit.pdf
Material Type
Book
Call Number
REF FE 220 CHI 2013
Availability
1 copy, 1 available
This guide describes the principles and processes involved in the development of the Chinese Peer Navigator Program at the BC Cancer Agency, Vancouver Centre and the bilingual resources that are used with Chinese-speaking patients (Mandarin, Cantonese and English).; This program also reflects “be…
  1 image     1 website  
Website
http://www.cw.bc.ca/library/pdf/2013PeerNavigatorToolkit.pdf
Author
Kwong, Sandy
Place of Publication
[Vancouver, BC?]
Publisher
BC Cancer Agency
Publication Date
2013
Physical Description
Softcover: 27 p.
Subject
Cancer-Coping
Cancer
Abstract
This guide describes the principles and processes involved in the development of the Chinese Peer Navigator Program at the BC Cancer Agency, Vancouver Centre and the bilingual resources that are used with Chinese-speaking patients (Mandarin, Cantonese and English).
This program also reflects “best practice” standards and can be used for future groups or organizations who may wish to adapt it for future peer navigator programs.
Language
English
Chinese
Material Type
Book
Call Number
REF FE 220 CHI 2013

Copies

Copy 1 BC Children's and Women's Study and Learning Commons Available
Images
Websites
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Chromosome segregation and meiotic defects in carriers of chromosomal abnormalities

https://cwslc.andornot.com/en/permalink/catalog113956
Kirkpatrick, Gordon. [Vancouver, BC?]: University of British Columbia , 2009.
Website
http://hdl.handle.net/2429/9705
Material Type
Thesis
Call Number
Thesis Shelf
Male carriers of chromosomal abnormalities (CA) are more frequent in the infertile population. These men have higher levels of sperm aneuploidy due to the aberrant segregation of the chromosomes involved in the abnormality. The presence of a CA may also influence the segregation of other chromosome…
Website
http://hdl.handle.net/2429/9705
Author
Kirkpatrick, Gordon
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2009
Subject
Faculty of Medicine
Theses
Abstract
Male carriers of chromosomal abnormalities (CA) are more frequent in the infertile population. These men have higher levels of sperm aneuploidy due to the aberrant segregation of the chromosomes involved in the abnormality. The presence of a CA may also influence the segregation of other chromosomes, in a process known as in interchromosomal effect (ICE). The behaviour of the CA during meiosis may account for the infertility observed in this population. We studied chromosome segregation, ICE and meiotic defects in a variety of CA. In carriers of CA, we determined the segregation patterns of chromosomes involved in the abnormality.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Clinical and endocrine responses to ovarian hyperstimulation in flare and and luteal gonadotropin-releasing hormone agonist (GnRHa) protocols

https://cwslc.andornot.com/en/permalink/catalog113958
Nguyen, Tuan-Anh T. [Vancouver, BC?]: University of British Columbia , 2008.
Website
http://hdl.handle.net/2429/1395
Material Type
Thesis
Call Number
Thesis Shelf
Due to the ?flare effect? associated with the flare protocol, variation in the degree of follicular maturation during stimulation may result in differences in follicle response as compared to the luteal protocol which is based on maximal pituitary suppression and synchronization of follicular matur…
Website
http://hdl.handle.net/2429/1395
Author
Nguyen, Tuan-Anh T
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2008
Subject
Faculty of Medicine
Theses
Abstract
Due to the ?flare effect? associated with the flare protocol, variation in the degree of follicular maturation during stimulation may result in differences in follicle response as compared to the luteal protocol which is based on maximal pituitary suppression and synchronization of follicular maturation. In this study, besides other methods, Anti-Mullerian Hormone (AMH), a novel marker for ovarian reserve, was used as a tool to evaluate the ovarian responsiveness to stimulation.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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Clinical wisdom and interventions in critical care: A thinking-in-action approach

https://cwslc.andornot.com/en/permalink/catalog113138
Benner, Patricia, Hooper-Kyriakidis, Patricia, Stannard, Daphne. [Toronto, ON]: W.B. Saunders Company , 1999.
Material Type
Book
Call Number
REF JC 500 BEN 1999
Availability
1 copy, 1 available
This book examines how expert critical care nurses use scientific knowledge, professional experience, and a careful attention to each patient's changing condition to provide excellent nursing care. Based on descriptive interviews and observational studies of 205 nurses, it helps readers at all leve…
Author
Benner, Patricia
Hooper-Kyriakidis, Patricia
Stannard, Daphne
Place of Publication
[Toronto, ON]
Publisher
W.B. Saunders Company
Publication Date
1999
Physical Description
Softcover: 566 p.
Subject
Nursing. Registered Nurse. RN
Abstract
This book examines how expert critical care nurses use scientific knowledge, professional experience, and a careful attention to each patient's changing condition to provide excellent nursing care. Based on descriptive interviews and observational studies of 205 nurses, it helps readers at all levels develop the critical-thinking, reasoning, judgment, and intervention skills they need to become critical-care nurses.
ISBN
0721675115
Language
English
Material Type
Book
Call Number
REF JC 500 BEN 1999

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Communicating risks and benefits: An evidence-based user's guide

https://cwslc.andornot.com/en/permalink/catalog111871
Fischhoff, Baruch, Brewer, Noel T., Downs, Julie S.(eds.). Maryland, USA: FDA, US Department of Health & Human Services , 2011.
Website
http://www.cw.bc.ca/library/pdf/Risk communication book remediated2.pdf
Material Type
Book
Online
Effective risk communication is essential to the well-being of any organization and those people who depend on it. Ineffective communication can cost lives, money, and reputations. Communicating Risks and Benefits: An Evidence-Based User's Guide provides the scientific foundations for effective …
Website
http://www.cw.bc.ca/library/pdf/Risk communication book remediated2.pdf
Website Notes
Click on the link above to view/print.
Author
Fischhoff, Baruch
Brewer, Noel T.
Downs, Julie S.(eds.)
Corporate Author
Food & Drug Administration (FDA), US Department of Health & Human Services
Place of Publication
Maryland, USA
Publisher
FDA, US Department of Health & Human Services
Publication Date
2011
Physical Description
PDF file: 242 p.
Subject
Leadership/Coaching
Communication
Abstract
Effective risk communication is essential to the well-being of any organization and those people who depend on it. Ineffective communication can cost lives, money, and reputations. Communicating Risks and Benefits: An Evidence-Based User's Guide provides the scientific foundations for effective communication.
Language
English
Material Type
Book
Online
Websites
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Crisis Management in Acute Care Settings: Human Factors, Team Psychology, and Patient Safety in a High Stakes Environment

https://cwslc.andornot.com/en/permalink/catalog114233
St. Pierre, Michael, Buerschaper, Cornelius, Simon, Robert. Berlin, Germany: Springer-Verlag , 2011. 2nd Ed.
Material Type
Book
Call Number
REF EB 800 STP 2011
Availability
1 copy, 1 available
Critical situations in acute and emergency care are one of the great clinical challenges because of the uncertainty, high stakes, time pressure, and stress that are involved. This book provides a comprehensive outline of all the human factors issues relevant to patient safety during acute care. Fol…
Author
St. Pierre, Michael
Buerschaper, Cornelius
Simon, Robert
Edition
2nd Ed.
Place of Publication
Berlin, Germany
Publisher
Springer-Verlag
Publication Date
2011
Physical Description
Hardcover: 346 pages
Subject
Emergency Care Services. Emergency Room. ER
Emergency Medicine
Safety
Abstract
Critical situations in acute and emergency care are one of the great clinical challenges because of the uncertainty, high stakes, time pressure, and stress that are involved. This book provides a comprehensive outline of all the human factors issues relevant to patient safety during acute care. Following an initial section discussing the basic principles of human behavior and decision making, the various influences on safe patient care are discussed in depth. These are divided into three interacting groups: individual factors, team factors, and organizational factors. Relevant psychological theories are carefully examined, and case studies and descriptions of proven strategies help to ground these theories in daily practice. This newly revised edition will help both physicians and non-physicians to better understand the principles of human behavior and decision making in critical situations and thus to provide safer treatment.
ISBN
9783642196997
Language
English
Material Type
Book
Call Number
REF EB 800 STP 2011

Copies

Copy 1 BC Children's and Women's Study and Learning Commons Available
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Curriculum development in nursing education

https://cwslc.andornot.com/en/permalink/catalog112443
Iwasiw, Carroll L., Goldenberg, Dolly, Andrusyszyn, Mary-Anne. Sudbury, MA: Jones and Bartlett Publishers , 2009. 2nd ed.
Material Type
Book
Call Number
REF AA 75 IWA 2009
Availability
1 copy, 1 available
The second edition of this book has been completely revised and updated and includes an expanded focus on developing a context-relevant curriculum. A major determinant in any nursing education curriculum is the context in which the curriculum is developed and offered. This context is the profession…
Author
Iwasiw, Carroll L.
Goldenberg, Dolly
Andrusyszyn, Mary-Anne
Edition
2nd ed.
Place of Publication
Sudbury, MA
Publisher
Jones and Bartlett Publishers
Publication Date
2009
Physical Description
Softcover: 355 p.
Subject
Nursing. Registered Nurse. RN
Leadership/Coaching
Abstract
The second edition of this book has been completely revised and updated and includes an expanded focus on developing a context-relevant curriculum. A major determinant in any nursing education curriculum is the context in which the curriculum is developed and offered. This context is the professional, societal, health care, and educational situations to which the curriculum must respond, and is what makes each school's curriculum unique. This book helps nurse educators create a program of study that will meet the contextual needs of their individual setting.
Notes
RESTRICTED TO PHSA LEADERSHIP COACHING PARTICIPANTS ONLY.
Language
English
Material Type
Book
Call Number
REF AA 75 IWA 2009

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Defining excellence in simulation programs

https://cwslc.andornot.com/en/permalink/catalog113768
Palaganas, Janice, Maxworthy, Juli, Epps, Chad, Mancini, Mary. Philadelphia, PA: Society for Simulation in Healthcare , 2015.
Material Type
Book
Call Number
REF AA 320 PAL 2015
Availability
1 copy, 1 available
Defining Excellence in Simulation Programsis an official publication of the Society for Simulation in Healthcare (SSH), created to support the Society's mission to encourage excellence in healthcare education, practice and research through the use of simulation.
Author
Palaganas, Janice
Maxworthy, Juli
Epps, Chad
Mancini, Mary
Place of Publication
Philadelphia, PA
Publisher
Society for Simulation in Healthcare
Publication Date
2015
Physical Description
26.9 x 21.3 x 2.5 cm
Subject
Nursing Education
Patient Simulation
Abstract
Defining Excellence in Simulation Programsis an official publication of the Society for Simulation in Healthcare (SSH), created to support the Society's mission to encourage excellence in healthcare education, practice and research through the use of simulation.
ISBN
9781451188790
Language
English
Material Type
Book
Call Number
REF AA 320 PAL 2015

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Deja review: Emergency Medicine

https://cwslc.andornot.com/en/permalink/catalog112738
Jang, David H. New York, NY: McGraw-Hill Companies, Inc. , 2011. 2nd Ed.
Material Type
Book
Call Number
REF EB 822 JAN 2011
Availability
1 copy, 1 available
This text boils down your coursework to just the critical concepts you need to know for exam success. This unbeatable guide features a quick-read, two-column, “flashcard in a book” Q&A format. – specifically designed to help you remember a large amount of pertinent information in the least amount o…
Author
Jang, David H.
Edition
2nd Ed.
Place of Publication
New York, NY
Publisher
McGraw-Hill Companies, Inc.
Publication Date
2011
Physical Description
Paperback: 480 pages
Subject
Emergency Medicine-Directories. Thesauri. Glossaries
Medical Directories. Resource Guides
UBC MD Undergrad
Abstract
This text boils down your coursework to just the critical concepts you need to know for exam success. This unbeatable guide features a quick-read, two-column, “flashcard in a book” Q&A format. – specifically designed to help you remember a large amount of pertinent information in the least amount of time possible. The format allows you to zero-in on only the correct answers to promote memory retention and get the most out of your study time. Deja Review provides a straightforward way for you to assess your strengths and weaknesses so you can excel on the clerkship and the USMLE Step 2 CK.
ISBN
978-0071715188
Language
English
Material Type
Book
Call Number
REF EB 822 JAN 2011

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Deja review: Family medicine

https://cwslc.andornot.com/en/permalink/catalog112735
Perez, Mayra, Liaw, Winston, Botsford, Lindsay. New York, NY: McGraw-Hill Companies, Inc. , 2011. 2nd Ed.
Material Type
Book
Call Number
REF FA 310 PER 2011
Availability
1 copy, 1 available
This text boils down your coursework to just the critical concepts you need to know for exam success. Features a quick-read, two-column, “flashcard in a book” Q&A format. – specifically designed to help you remember a large amount of pertinent information in the least amount of time possible. The f…
Author
Perez, Mayra
Liaw, Winston
Botsford, Lindsay
Edition
2nd Ed.
Place of Publication
New York, NY
Publisher
McGraw-Hill Companies, Inc.
Publication Date
2011
Physical Description
Paperback, 402 pages.
Subject
Family Medicine
Medical Directories. Resource Guides
Family Medicine-Directories.Resource Guides
UBC MD Undergrad
Abstract
This text boils down your coursework to just the critical concepts you need to know for exam success. Features a quick-read, two-column, “flashcard in a book” Q&A format. – specifically designed to help you remember a large amount of pertinent information in the least amount of time possible. The format allows you to zero-in on only the correct answers to promote memory retention and get the most out of your study time. Deja Review provides a straightforward way for you to assess your strengths and weaknesses so you can excel on the clerkship and the USMLE Step 2 CK.
ISBN
978-0-07-171515-7
Language
English
Material Type
Book
Call Number
REF FA 310 PER 2011

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
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Deja review: Internal medicine

https://cwslc.andornot.com/en/permalink/catalog112754
Mobasser, Sarvenaz S. Saadat. New York, NY: McGraw-Hill Companies, Inc. , 2011. 2nd Ed.
Material Type
Book
Call Number
REF AB 60 MOB 2011
Availability
2 copies, 2 available
This text boils down your coursework to just the critical concepts you need to know for exam success. This unbeatable guide features a quick-read, two-column, “flashcard in a book” Q&A format. – specifically designed to help you remember a large amount of pertinent information in …
Author
Mobasser, Sarvenaz S. Saadat
Edition
2nd Ed.
Place of Publication
New York, NY
Publisher
McGraw-Hill Companies, Inc.
Publication Date
2011
Physical Description
Paperback: 254 pages.
Subject
Internal Medicine
Medical Directories. Resource Guides
UBC MD Undergrad
Abstract
This text boils down your coursework to just the critical concepts you need to know for exam success. This unbeatable guide features a quick-read, two-column, “flashcard in a book” Q&A format. – specifically designed to help you remember a large amount of pertinent information in the least amount of time possible. The format allows you to zero-in on only the correct answers to promote memory retention and get the most out of your study time. Deja Review provides a straightforward way for you to assess your strengths and weaknesses so you can excel on the clerkship and the USMLE Step 2 CK.
ISBN
978-0071715171
Language
English
Material Type
Book
Call Number
REF AB 60 MOB 2011

Copies

Copy 1 BC Children's and Women's Study and Learning Commons REF Available
Copy 2 BC Children's and Women's Study and Learning Commons REF Available
Images
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Digital game-based learning

https://cwslc.andornot.com/en/permalink/catalog110133
Prensky, Marc. St. Paul, MN: Paragon House , 2001.
Material Type
Book
Call Number
REF AA 85 PRE 2001
Availability
1 copy, 1 available
Digital Game-Based Learning (DGBL) consists of two parts. In the first part, Prensky argues that the prevalence of video games has actually rewired our brains and made traditional learning methods less effective. In the second part, Prensky makes the case that DGBL can be used successfully by corpo…
Author
Prensky, Marc
Place of Publication
St. Paul, MN
Publisher
Paragon House
Publication Date
2001
Physical Description
Paperback, 442 p.
Subject
Education. Gaming
Abstract
Digital Game-Based Learning (DGBL) consists of two parts. In the first part, Prensky argues that the prevalence of video games has actually rewired our brains and made traditional learning methods less effective. In the second part, Prensky makes the case that DGBL can be used successfully by corporations to train people and offers practical advice (based on vast experience) about how to deploy game-based training methods. Throughout the book, Prensky examines aesthetic, cognitive and pedagogical questions surrounding such games and provides dozens of case studies to illustrate his points.
ISBN
1557788634
Language
English
Material Type
Book
Call Number
REF AA 85 PRE 2001

Copies

Copy 1 BC Children's and Women's Study and Learning Commons Available
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DNA methylation at imprinted and non-imprinted genes in the sperm of men affected by severe male factor infertility

https://cwslc.andornot.com/en/permalink/catalog113950
Minor, Agata. [Vancouver, BC?]: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/29282
Material Type
Thesis
Call Number
Thesis Shelf
Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA met…
Website
http://hdl.handle.net/2429/29282
Author
Minor, Agata
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
Abnormal DNA methylation at imprinted and non-imprinted genes has been associated with spermatogenesis failure. However, little information is available regarding DNA methylation at those genes in men affected by severe male factor infertility. We hypothesized a higher incidence of aberrant DNA methylation would be present in the ejaculate and testicular sperm of men affected by severe male factor infertility compared to that in fertile control men. Furthermore, we hypothesized abnormal DNA methylation would also affect non-imprinted genes in the sperm of men affected by severe oligozoospermia.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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E-cadherin promotes tumorigenicity in human ovarian surface epithelium

https://cwslc.andornot.com/en/permalink/catalog113975
Ong, Aldrich Dixon. [Vancouver, BC?]: University of British Columbia , 1999.
Website
http://hdl.handle.net/2429/9760
Material Type
Thesis
Call Number
Thesis Shelf
Ovarian cancer is the most lethal gynecological cancer in the Western world, but comparatively little is known about its development. Epithelial ovarian carcinomas are thought to originate in the ovarian surface epithelium (OSE), i.e. the mesothelium covering the ovary, but experimental evidence fo…
Website
http://hdl.handle.net/2429/9760
Author
Ong, Aldrich Dixon
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1999
Subject
Faculty of Medicine
Theses
Abstract
Ovarian cancer is the most lethal gynecological cancer in the Western world, but comparatively little is known about its development. Epithelial ovarian carcinomas are thought to originate in the ovarian surface epithelium (OSE), i.e. the mesothelium covering the ovary, but experimental evidence for this origin has been lacking. Contrary to most epithelia where neoplastic progression is associated with loss of E-cadherin, this cell-cell adhesion molecule is sparse in normal human OSE but its expression increases in ovarian epithelial metaplasia and neoplasia.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
Show Less

Effects and mechanisms of growth differentiation factor 9 on activin A-regulated inhibin B and progesterone production in human granulosa cells

https://cwslc.andornot.com/en/permalink/catalog113951
Shi, Fengtao. [Vancouver, BC?]: University of British Columbia , 2010.
Website
http://hdl.handle.net/2429/28961
Material Type
Thesis
Call Number
Thesis Shelf
Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regul…
Website
http://hdl.handle.net/2429/28961
Author
Shi, Fengtao
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
2010
Subject
Faculty of Medicine
Theses
Abstract
Activin A (homodimer of inhibin βA-subunit) is known to increase inhibin βB-subunit and inhibin B (heterodimer of inhibin α- and βB-subunit) levels and decrease progesterone accumulation in human granulosa cells. Growth differentiation factor 9 (GDF9) is a potent paracrine regulator of ovarian function, but its overall effects, particularly relating to activin A actions, are unknown. We examined the potential crosstalk between activin A and GDF9 in primary cultures of human granulosa-lutein (hGL) cells. Pretreatment of hGL cells with GDF9 for 24 h resulted in an increased expression of activin receptors and Smad2/3, and decreased inhibitory Smad7 activity. These effects were attenuated by BMP type II receptor ectodomain (BMPR2 ECD), a GDF9 antagonist.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
Websites
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The effects of clomiphene citrate on ovarian function in rats

https://cwslc.andornot.com/en/permalink/catalog113993
Feng, Tian Bin. [Vancouver, BC?]: University of British Columbia , 1990.
Website
http://hdl.handle.net/2429/28984
Material Type
Thesis
Call Number
Thesis Shelf
In the present study, the effects of clomiphene citrate (CC) on ovulation, ovarian growth and ovarian steroidogenesis were examined. Ovulation in rats in response to PMSG was completely blocked by administration of three daily treatments of 1.0 mg CC/rat, but was restored by administration of hCG a…
Website
http://hdl.handle.net/2429/28984
Author
Feng, Tian Bin
Place of Publication
[Vancouver, BC?]
Publisher
University of British Columbia
Publication Date
1990
Subject
Faculty of Medicine
Theses
Abstract
In the present study, the effects of clomiphene citrate (CC) on ovulation, ovarian growth and ovarian steroidogenesis were examined. Ovulation in rats in response to PMSG was completely blocked by administration of three daily treatments of 1.0 mg CC/rat, but was restored by administration of hCG as a preovulatory LH surge substitute. When the number of treatment days was reduced to two days, 1.0 mg of CC enhanced ovulation in response to PMSG, whereas treatment for one day with the same dose of CC did not affect ovulation.
Language
English
Material Type
Thesis
Call Number
Thesis Shelf
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